- μέγεθος γραμματοσειράς μείωση του μεγέθους γραμματοσειράς αύξηση μεγέθους γραμματοσειράς
Παναγιώτα Ποϊράζη
Τα ερευνητικά μου ενδιαφέροντα ανήκουν στο χώρο της υπολογιστικής βιολογίας και εστιάζονται στην ανάπτυξη και εφαρμογή υπολογιστικών μεθόδων για την διερεύνηση προβλημάτων που αφορούν στην λειτουργία νευρικών και γενετικών μηχανισμών. Στο εργαστήριό μου αναπτύσσουμε υπολογιστικές μεθόδους και εργαλεία με σκοπό (α) την ανάλυση μεγάλου όγκου δεδομένων γονιδιακής έκφρασης που σχετίζονται με καρκίνο με στόχο τον εντοπισμό γονιδιακών δεικτών και υποκατηγοριών της ασθένειας, (β) τον εντοπισμό ρυθμιστικών μορίων όπως τα miRNAs και πιθανών στόχων τους στο γονιδίωμα φυτών και θηλαστικών, (γ) την ανάπτυξη θεωρητικών μοντέλων βιολογικών δικτύων και (δ) τη μοντελοποίηση νευρικών κυττάρων και δικτύων κάτω από κανονικές και παθολογικές συνθήκες με στόχο τη συσχέτιση της ικανότητας μνήμης και μάθησης με τις βιοφυσικές και μορφολογικές ιδιότητες του νευρικού ιστού. Οι μεθοδολογικές μας προσεγγίσεις περιλαμβάνουν (α) νέους αλγορίθμους ομαδοποίησης και εξαγωγής χαρακτηριστικών, (β) αλγορίθμους μηχανικής μάθησης όπως τα Τεχνητά Νευρωνικά Δίκτυα και τα Κρυφά Μαρκοβιανά μοντέλα, (γ) λεπτομερή διαμερισματοποιημένα και/ή απλοποιημένα μοντέλα νευρικών κυττάρων και δικτύων και (δ) θεωρητική ανάλυση και αφαιρετική μαθηματική μοντελοποίηση.
Sidiropoulou, K. and Poirazi, P. (2012) Predictive Features of Persistent Activity Emergence in Regular Spiking and Intrinsic Bursting Model Neurons. PLoS Comput Biol 8: e1002489. doi:10.1371/journal.pcbi.1002489
Shilyansky, C, Karlsgodt, KH, Cummings, D, Sidiropoulou, K, Hardt, M, James, AS, Ehninger, D, Bearden, CE, Poirazi, P, Jentsch, D, Cannon, TD, Levine, MS, Silva, AJ. (2010) Increased corticostriatal inhibition underlies working memory deficits in Neurofibromatosis type I. Proc Natl Acad Sci USA 107: 13141-6.
Zhou Y, Won J, Karlsson MG, Zhou M, Rogerson T, Balaji J, Neve R, Poirazi P, Silva AJ. (2009) CREB regulates excitability and the allocation of memory to subsets of neurons in the amygdala. Nature Neuroscience 12: 1438-43.
Oulas, A. Boutla, A. Gkirtzou, K. Reczko, M. Kalantidis, K. and Poirazi, P. (2009) Prediction of novel microRNA genes in cancer associated genomic regions: a combined computational and experimental approach. Nucleic Acid Research 7: 3276-3287.
Poirazi, P. Brannon, T. & Mel, B.W. (2003) Pyramidal Neuron as 2-Layer Neural Network. Neuron/37: 989-999.
Journal Publications
2016
Poirazi, P., Belin, D., Gräff, J., Hanganu‐Opatz, I., and López‐Bendito, G. “Balancing family with a successful career in neuroscience”. European Journal of Neuroscience, 2016. | http://dx.doi.org/10.1111/ejn.13280
Spires-Jones, T.L., Poirazi, P., Grubb, M.S., “Opening Up: open access publishing, data sharing, and how they can influence your neuroscience career”, European Journal of Neuroscience, 04 March 2016 | http://dx.doi.org/10.1111/ejn.13234
[Abstract] [PDF]
2015
2014
2013
[Abstract] [PDF]
Manioudaki ME and Poirazi P
Modeling regulatory cascades using Artificial Neural Networks: the case of transcriptional regulatory networks shaped during the yeast stress response.
Front. Genet. 4:110. doi: 10.3389/fgene.2013.00110
[Abstract] [PDF]
A. Papoutsi, G. Kastellakis, M. Psarrou, S. Anastasakis, P. Poirazi.
Coding and Decoding with Dendrites
Journal of Physiology-Paris doi:10.1016/j.jphysparis.2013.05.003.
[Abstract] [PDF]
Romani, A., Marchetti, C., Bianchi, D., Leinekugel, X., Poirazi, P., Migliore, M., Marie, H.
Computational modeling of the effects of amyloid-beta on release probability at hippocampal synapses.
Frontiers in Computational Neuroscience, January 2013; doi: 10.3389/fncom.2013.00001
[Abstract] [PDF]
2012
2011
Gómez González JF, Mel BW, Poirazi P.
Distinguishing Linear vs. Non-Linear Integration in CA1 Radial Oblique Dendrites: It’s about Time.
Frontiers in Computational Neuroscience. 2011 November 14 ;5:44.
[Abstract] [PDF]
Tzamali E, Poirazi P, Tollis IG, Reczko M.
A computational exploration of bacterial metabolic diversity identifying metabolic interactions and growth-efficient strain communities.
BMC Syst Biol. 2011 Oct 18;5:167.
[Abstract] [PDF]
Oulas, A, Karathanassis N., Luloupi, A. and Poirazi, P.
Finding cancer-associated miRNAs: methods and tools
Molecular Biotechnology, DOI: 10.1007/s12033-011-9416-4, June 2011.
[Abstract] [PDF]
2010
Pissadaki E.K., Sidiropoulou K., Reczko M., and Poirazi P.
Encoding of Spatio-temporal Input Characteristics by a CA1 Pyramidal Neuron Model.
PLoS Computational Biology 2010 Dec;6(12): e1001038.
[Abstract] [PDF]
Gkirtzou K, Tsamardinos I, Tsakalides P, Poirazi P.
MatureBayes: a probabilistic algorithm for identifying the mature miRNA within novel precursors.
PLoS One 2010 Aug;5(8). pii: e11843
[Abstract] [PDF]
Shilyansky C, Karlsgodt KH, Cummings DM, Sidiropoulou K, Hardt M, James AS, Ehninger D, Bearden CE, Poirazi P, Jentsch JD, Cannon TD, Levine MS, Silva AJ.
Neurofibromin regulates corticostriatal inhibitory networks during working memory performance.
Proc Natl Acad Sci U S A. 2010 Jul;107(29):13141-6.
[Abstract] [PDF]
2009
Zhou Y, Won J, Karlsson MG, Zhou M, Rogerson T, Balaji J, Neve R, Poirazi P, Silva AJ.
CREB regulates excitability and the allocation of memory to subsets of neurons in the amygdala.
Nature Neuroscience 2009 Nov;12(11):1438-43.
[Abstract] [PDF]
Oulas A, Boutla A, Gkirtzou K, Reczko M, Kalantidis K and Poirazi P
Prediction of novel microRNA genes in cancer-associated genomic regions–a combined computational and experimental approach.
Nucleic Acids Research 2009 Jun;37(10):3276-87.
[Abstract] [PDF]
Oulas A, Reczko M and Poirazi P.
MicroRNAs and Cancer-the search begins!
IEEE Trans Inf Technol Biomed. vol. 13, No 1, pg. 67-77, Jan 2009.
[Abstract] [PDF]
2008
Petalidis LP, Oulas A, Backlund M, Wayland MT, Liu L, Plant K, Happerfield L, Freeman TC, Poirazi P, Collins VP.
Improved grading and survival prediction of human astrocytic brain tumors by artificial
neural network analysis of gene expression microarray data.
Molecular Cancer Therapeutics (on the cover) vol. 7, No 5, pg. 1013-1024, May 2008.
[Abstract] [PDF]
Liebmann L, Karst H, Sidiropoulou K, van Gemert N, Meijer OC, Poirazi P, Joels M.
Differential effects of corticosterone on the slow afterhyperpolarization in the
basolateral amygdala and CA1 region: possible role of calcium channel subunits.
Journal of Neurophysiology vol. 99, No 2, pg. 958-968, Feb. 2008.
[Abstract] [PDF]
2007
Poirazi, P., Leroy, F., Georgalaki, M.D., Aktypis, A., De Vuyst, L., and Tsakalidou, E.
Use of artificial neural networks and a gamma-concept-based approach to model growth of and bacteriocin production
by Streptococcus macedonicus ACA-DC 198 under conditions simulating Kasseri cheese technology.
Applied Environmental Microbiology vol. 73, No 3, pg. 768-776, Feb. 2007.
[Abstract] [PDF]
Pissadaki, E.K. and Poirazi P.
Modulation of excitability in CA1 pyramidal neurons via the interplay of EC and CA3 inputs.
Neurocomputing, Special Issue for CNS 2006, vol. 70, No 11-12, pg. 1735-1740, June 2007.
[Abstract][PDF]
Sidiropoulou K., Joels M., and Poirazi P.
Modeling stress-induced adaptations in Ca++ dynamics.
Neurocomputing, Special Issue for CNS 2006, vol. 70, No 11-12, pg. 1640-1644, June 2007.
[Abstract][PDF]
2006
Pavlidis P. and Poirazi P.
Individualized markers optimize class prediction of microarray data.
BMC Bioinformatics, vol. 7, pg. 345-359, July 2006.
[Abstract] [PDF]
Sidiropoulou K., Pissadaki E.K., and Poirazi P.
Inside the brain of a neuron.
EMBO Reports, vol. 7, pg. 886-892, September 2006.
[Abstract] [PDF]
2005
Markaki M., Orphanoudakis S. and Poirazi P.
Modelling reduced excitability in aged CA1 neurons as a calcium-dependent process.
Neurocomputing, vol. 65-66, pg. 305-314, June 2005.
[Abstract] [PDF]
2004
Poirazi, P. Neocleous, C., Pattichis, C. and Schizas, C.
Classification Capacity of a Modular Neural Network Implementing Neurally Inspired Architecture and Training.
IEEE Transactions in Neural Networks, vol 15, No. 3, pg. 597-612, May 2004.
[Abstract] [PDF]
2003
Poirazi, P. Brannon, T. and Mel, B.W.
Arithmetic of Subthreshold Synaptic Summation in a Model CA1 Pyramidal Cell.
Neuron, vol 37, pg. 977-987, March 2003.
[Abstract] [PDF]
Poirazi, P. Brannon, T. and Mel, B.W.
Pyramidal Neuron as 2-Layer Neural Network.
Neuron, vol 37, pg. 989-999, March 2003.
[Abstract] [PDF]
Poirazi, P. Brannon, T. and Mel, B.W.
About the Model (online supplement)
Neuron, vol 37, pg. 988, March 2003.
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1999-2001
Poirazi, P. and Mel, B.W.
Impact of Active Dendritic Processing and Structural Plasticity on Learning and Memory.
Neuron, vol 29, pg. 779-796, March 2001.
[Abstract] [PDF]
Poirazi, P. and Mel, B.W.
Choice and value flexibility jointly contribute to the capacity of a subsampled quadratic classifier.
Neural Computation, vol. 12, num. 5, pg. 1189-1207, 2000.
[Abstract] [PDF]
Poirazi, P. and Mel, B.W.
Towards the Memory Capacity of Neurons with Active Dendrites.
Neurocomputing, vol. 26-27, pg. 237-245, 1999.
[Abstract] [PDF]