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DNA Damage Triggers a Chronic Autoinflammatory Response, Leading to Fat Depletion in NER Progeria

DNA Damage Triggers a Chronic Autoinflammatory Response, Leading to Fat Depletion in NER Progeria

Using mice defective in DNA repair, Karakasilioti et al., show that DNA damage triggers a chronic auto-inflammatory response leading to fat depletion. The findings highlight the role of irreparable DNA lesions in adipose tissue degeneration with important ramifications for progressive lipodystrophies and natural aging.

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