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Structural Instability Tuning as a Regulatory Mechanism in Protein-Protein Interactions

Structural Instability Tuning as a Regulatory Mechanism in Protein-Protein Interactions

The Economou lab in collaboration with the Kalodimos lab (Rutgers U.) reveal a novel regulatory mechanism in protein-protein interactions. Chen et al show that the interaction of a chaperone with its substrate is mediated by finely tuned structural instability and is coupled to molecular mimicry.