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Distinct intracellular motifs of Delta mediate its ubiquitylation and activation by Mindbomb1 and Neuralized

Distinct intracellular motifs of Delta mediate its ubiquitylation and activation by Mindbomb1 and Neuralized

IMBB researchers contribute to the unraveling of the molecular mechanism of Notch signalling. Daskalaki et al show that ubiquitylation of the Notch ligand Delta simultaneously triggers its endocytosis and its signalling activity.