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Dimitris Kafetzopoulos

Dimitris Kafetzopoulos

Principal Researcher
Email address
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Phone
+30-2810-391594
Fax
+30-2810-391110

The laboratory has a strong background in Molecular Biotechnology and a clear inclination for multidisciplinary and applied research, as these are witnessed by a wide range of scientific publications and patents spanning from Biomedical Informatics to Biomaterials and from Bioconversions to Molecular Diagnostics. Nevertheless, our main research interests for more than ten years now, remain within the field of Post-Genomic analysis and in particular the molecular profiling of complex diseases and the elucidation of the mechanisms underlying them.

Our current research focuses on the processes involved in Cancer Metastasis and specifically on the role of Circulating Tumor Cells. CTCs are cancer cells that have disseminated from the primary tumor to the blood circulation. Several experimental and clinical studies associate the presence of CTCs with the development of metastasis and the poor prognosis of the disease. However, neither all patients with detectable CTCs develop metastases nor all patients without detectable CTCs escape relapse. In this respect, our research aims at the development of new methods for the isolation, culture, functional characterization and single-cell-profiling of CTCs in order to identify discrete subpopulations with high metastatic potential and/or recognize specific conditions that lead to the establishment of metastases.

To further support the above objectives we have also established several lines of research collaborations for the development of microfluidic devices, the establishment of advanced molecular imaging methods and the interpretation, visualization and integration of post-genomic data.

Zervakis, M., Blazadonakis, M.E., Tsiliki, G., Danilatou, V., Tsiknakis, M., and Kafetzopoulos, D. (2009) Outcome prediction based on microarray analysis: a critical perspective on methods. BMC Bioinformatics. 10: 53.

Tatarakis, A., Margaritis, T., Martinez-Jimenez, C.P., Kouskouti, A., Mohan, W.S., 2nd, Haroniti, A., Kafetzopoulos, D. Tora, L., and Talianidis, I. (2008) Dominant and redundant functions of TFIID involved in the regulation of hepatic genes. Mol Cell . 31: 531-43.

Falara, V., Fotopoulos, V., Margaritis, T., Anastasaki, T., Pateraki, I., Bosabalidis, A.M., Kafetzopoulos, D., Demetzos, C., Pichersky, E., and Kanellis, A.K. (2008) Transcriptome analysis approaches for the isolation of trichome-specific genes from the medicinal plant Cistus creticus subsp. creticus. Plant Mol Biol . 68: 633-51.

Dinca, V., Ranella, A., Farsari, M., Kafetzopoulos, D., Dinescu, M., Popescu, A., and Fotakis, C. (2008) Quantification of the activity of biomolecules in microarrays obtained by direct laser transfer. Biomed Microdevices . 10: 719-25.

Tsiknakis, M., Kafetzopoulos, D., Potamias, G., Analyti, A., Marias, K., and Manganas, A. (2006) Building a European biomedical grid on cancer: the ACGT Integrated Project. Stud Health Technol Inform . 120: 247-58.

Publications in Refereed Journals

Tsouti, V., Boutopoulos, C., Andreakou, P., Ioannou, M., Zergioti, I., Goustouridis, D., Kafetzopoulos, D., Tsoukalas, D., Normand, P., and Chatzandroulis, S., Detection of DNA mutations using a capacitive micro-membrane array. Biosens Bioelectron, 2010. 26(4):1588-92

Tsiliki, G., Zervakis, M., Ioannou, M., Sanidas, E., Stathopoulos, E., Potamias, G., Tsiknakis, M., and Kafetzopoulos, D., Multi-platform data integration in microarray analysis. IEEE Trans Inf Technol Biomed., 2010. 15(6):806-12

Blazadonakis, M.E., Zervakis, M., and Kafetzopoulos, D., Complementary Gene Signature Integration in Multiplatform Microarray Experiments. IEEE Trans Inf Technol Biomed, 2010. 15(1):155-63

Blazadonakis, M.E., Zervakis, M., and Kafetzopoulos, D., Integration of gene signatures using biologicall knowledge. Artificial Intelligence in Medicine, 2010. 53(1):57-71

Zervakis, M., Blazadonakis, M.E., Tsiliki, G., Danilatou, V., Tsiknakis, M., and Kafetzopoulos, D., Outcome prediction based on microarray analysis: a critical perspective on methods. BMC Bioinformatics, 2009. 10 : p. 53.

Tsouti, V., Boutopoulos, C., Andreakou, P., Ioannou, M., Zergioti, I., Goustouridis, D., Kafetzopoulos, D., Tsoukalas, D., Normand, P., and Chatzandroulis, S., Detection of the biotin-streptavidin interaction by exploiting surface stress changes on ultrathin Si membranes. Microelectronic Engineering, 2009. 86 : p. 1495.

Tsiknakis, M., Sfakianakis, S., Zacharioudakis, G., Umakis, L., Kanterakis, A., Potamias, G., and Kafetzopoulos, D., A semantically aware platform for the authoring and secure enactment of bioinformatics workflows. Conf Proc IEEE Eng Med Biol Soc, 2009. 2009 : p. 5625-8.

Koumakis, L., Moustakis, V., Tsiknakis, M., Kafetzopoulos, D., and Potamias, G., Supporting genotype-to-phenotype association studies with grid-enabled knowledge discovery workflows. Conf Proc IEEE Eng Med Biol Soc, 2009. 2009 : p. 6958-62.

Tsiknakis, M., Brochhausen, M., Nabrzyski, J., Pucacki, J., Sfakianakis, S.G., Potamias, G., Desmedt, C., and Kafetzopoulos, D., A semantic grid infrastructure enabling integrated access and analysis of multilevel biomedical data in support of postgenomic clinical trials on cancer. IEEE Trans Inf Technol Biomed, 2008. 12 (2): p. 205-17.

Tatarakis, A., Margaritis, T., Martinez-Jimenez, C.P., Kouskouti, A., Mohan, W.S., 2nd, Haroniti, A., Kafetzopoulos, D., Tora, L., and Talianidis, I., Dominant and redundant functions of TFIID involved in the regulation of hepatic genes. Mol Cell, 2008. 31 (4): p. 531-43.

Kanterakis, A., Kafetzopoulos, D., Moustakis, D., and Potamias, G., Mining Gene Expression Profiles and Gene Regulatory Networks: Identification of Phenotype-Specific Molecular Mechanisms. Lecture Notes in Artificial Intelligence, 2008. 5138 : p. 97-109.

Falara, V., Fotopoulos, V., Margaritis, T., Anastasaki, T., Pateraki, I., Bosabalidis, A.M., Kafetzopoulos, D., Demetzos, C., Pichersky, E., and Kanellis, A.K., Transcriptome analysis approaches for the isolation of trichome-specific genes from the medicinal plant Cistus creticus subsp. creticus. Plant Mol Biol, 2008. 68 (6): p. 633-51.

Dinca, V., Ranella, A., Farsari, M., Kafetzopoulos, D., Dinescu, M., Popescu, A., and Fotakis, C., Quantification of the activity of biomolecules in microarrays obtained by direct laser transfer. Biomed Microdevices, 2008. 10 (5): p. 719-25.

Dinca V, Farsari M, and Kafetzopoulos D., Patterning parameters for biomolecules microarrays constructed with nanosecond and femtosecond UV lasers. Thin Solid Films 2008. 516 : p. 6504-651

Boutopoulos, C., Andreakou, P., Kafetzopoulos, D., Chatzandroulis, S., and Zergioti, I., Direct laser printing of biotin microarrays on Low Temperature Oxide on Si substrates. Physica Status Solidi A- Applications and Materials Science, 2008. 205 : p. 2505-2508.

Tsiknakis, M., Grangeat, P., Binz, P.A., Potamias, G., Lisacek, F., Gerfault, L., Paulus, C., Manakanatas, D., Kritsotakis, V., Kondylakis, H., Perez, M., Plexousakis, D., Kaforou, S., and Kafetzopoulos, D., Functional specifications of an integrated proteomics information management and analysis platform. Conf Proc IEEE Eng Med Biol Soc, 2007. 2007 : p. 6065-9.

Tsiknakis, M., Kafetzopoulos, D., Potamias, G., Analyti, A., Marias, K., and Manganas, A., Building a European biomedical grid on cancer: the ACGT Integrated Project. Stud Health Technol Inform, 2006. 120 : p. 247-58.

Margaritis, T., Marias, K., and Kafetzopoulos, D., Improved microarray spot segmentation by combining two information channels. Conf Proc IEEE Eng Med Biol Soc, 2006. 1 : p. 5850-3.

Zergioti I., Karaiskou, A., Papazoglou, D.G., Fotakis, C., Kapsetaki, M., and Kafetzopoulos, D., Time resolved schlieren study of sub-pecosecond and nanosecond laser transfer of biomaterials. Applied Surface Science, 2005. 247 : p. 584-589.

Zergioti I., Karaiskou, A., Papazoglou, D., Fotakis, C., Kapsetaki, M., and Kafetzopoulos, D., Femtosecond laser microprinting of biometerials. Applied Physics Letters, 2005. 86 : p. 163902.

Karaiskou A., Zergioti I., Fotakis C., Kapsetaki E., and Kafetzopoulos D., Microfabrication of biomaterials by the sub-ps laser induced forward transfer process. Applied Surface Science, 2003. 208-209 : p. 245-249.

Gagou, M.E., Kapsetaki, M., Turberg, A., and Kafetzopoulos, D., Stage-specific expression of the chitin synthase DmeChSA and DmeChSB genes during the onset of Drosophila metamorphosis. Insect Biochem Mol Biol, 2002. 32 (2): p. 141-6.

Lopez-Lara, I.M., Kafetzopoulos, D., Spaink, H.P., and Thomas-Oates, J.E., Rhizobial NodL O-acetyl transferase and NodS N-methyl transferase functionally interfere in production of modified Nod factors. J Bacteriol, 2001. 183 (11): p. 3408-16.

Tsigos, I., Martinou, A., Kafetzopoulos, D., and Bouriotis, V., Chitin deacetylases: new, versatile tools in biotechnology. Trends Biotechnol, 2000. 18 (7): p. 305-12.

Kamst, E., Spaink, H.P., and Kafetzopoulos, D., Biosynthesis and secretion of rhizobial lipochitin-oligosaccharide signal molecules. Subcell Biochem, 1998. 29 : p. 29-71.

Martinou A., Kafetzopoulos D., and Bouriotis V., Chitin deacetylation by enzymatic means: monitoring of deacetylation process. Carbohydrate Research, 1995. 273 : p. 235-242.

Gasperi, G., Kafetzopoulos, D., Christodoulidou, A., Bouriotis, V., and Savakis, C., Isolation and partial characterization of two alcohol dehydrogenase isozymes from the medfly Ceratitis capitata. Insect Biochem Mol Biol, 1994. 24 (1): p. 87-94.

Martinou A., Kafetzopoulos D., and Bouriotis V., Isolation of chitin deacetylase from Mucor rouxii by immunoaffinity chromatography. Journal of Chromatography, 1993. 644 : p. 35-41.

Kafetzopoulos, D., Thireos, G., Vournakis, J.N., and Bouriotis, V., The primary structure of a fungal chitin deacetylase reveals the function for two bacterial gene products. Proc Natl Acad Sci U S A, 1993. 90 (17): p. 8005-8.

Kafetzopoulos, D., Martinou, A., and Bouriotis, V., Bioconversion of chitin to chitosan: purification and characterization of chitin deacetylase from Mucor rouxii. Proc Natl Acad Sci U S A, 1993. 90 (7): p. 2564-8.

Conference Proceedings

Purification and properties of chitin deacetylase from Mucor rouxii. Kafetzopoulos D, Martinou A and Bouriotis V. In Chitin Enzymology, (Muzzarelli RAA, ed.), pp. 147-154, 1993.

cDNA cloning of chitin deacetylase from Mucor rouxii. Kafetzopoulos D, Thireos G, Vournakis JN and Bouriotis V. In Chitin Enzymology, (Muzzarelli RAA, ed.), pp. 431-436, 1993.

The molecular basis of host specificity in the Rhizobium leguminosarum - plant interaction. Spaink HP, Kafetzopoulos D, Sautter C. Advances in Molecular Genetics of Plant-Microbe Interactions (Daniels et al. eds), Vol. 3, pp. 91-98, 1994.

Chitin deacetylation by enzymatic means. Kafetzopoulos D, Martinou A, Tsigos I, Christodoulidou A, Kavelaki P and Bouriotis V. Progress in Biotechnology, (Albergina L, Frontali L, Sensi P. eds.) ElsevierScience B. V., Vol 9, pp. 291-294, 1994.

The molecular basis of host specificity of rhizobia. Spaink HP, Kafetzopoulos D, Wijfjes AHM. Biology of Plant-Microbe Interactions, (Stacey G, Mullin B, Gresshoff PM eds.), pp.299-306, 1996.

Chitin deacetylases: Function and Biological Implications. Cloning and Characterization of two new Chitin Deacetylases from Saccharomyces cerevisiae. Christod?ulidou A, Martinou A, Kafetzopoulos D, Tsigos I, Thireos G and Bouriotis V. In Chitin Enzymology (Muzzarelli RAA ed.), Atec Edizioni-Grottammare, Vol 2, pp. 405-414, 1996.

Development of DNA microarrays for the identification of new molecular markers to be exploited in sugar beet breeding. M. Kapsetaki, M. Vytova, A. Petraki, O. Koutita, G. Dialinas, N. J. Panopoulos, G. N. Skaracis and D. Kafetzopoulos. Genetics and Breeding, Proceedings of the 67th of the International Institute for Beet Research Congress, pp209-218, 2004

Breast cancer, microarrays and biomedical informatics: The Prognochip Project. G. Potamias, A. Analyti, D. Kafetzopoulos, M. Tsiknakis, D. Plexousakis, P. Poirazi, M. Reczko, Y. Tollis, E. Stathopoulos, S. Vassilaros Proceedings of the 1st International Advanced Research Workshop on In Silico Oncology: Advances and Challenges (1ST IARWISO), 2004

Integrated clinico-genomics environment: Design and operational specification. G. Potamias, D. Kafetzopoulos, M. Tsiknakis. Journal for Quality of Life Research (JQLR), 2nd International Conference on Information Communication Technologies in Health, 2:1, 145-150.

Breast Cancer and Biomedical Informatics: The PrognoChip Project. Potamias G., Analyti, A., Kafetzopoulos, D., Kafousi M., Margaritis T., Plexousakis D., Poirazi P., Reczko M., Tollis I.G., Sanidas M.E., Stathopoulos E., Tsiknakis M., Vassilaros S. IMACS 2005: Computer Science and Artificial Intelligence-Bioinformatics session (organizer: Casimir Kulikowski), Paris, France July 11 - 15, 2005 (invited by the session organiser).

Knowledge Discovery Scientific Workflows in Clinico-Genomics. Potamias, G.; Koumakis, L.; Kanterakis, A.; Sfakianakis, S.; Analyti, A.; Moustakis, V.; Kafetzopoulos, D.; Rueping, S.; Tsiknakis, M. Intl Conf IEEE Tools Artif Intellig, Volume 1, 2007; 91-95

Developing a European Biomedical Grid on Cancer: The ACGT Integrated Project M. Tsiknakis, D. Kafetzopoulos, G. Potamias, C. Marias, A. Analyti and A. Manganas, Proceedings of HealthGRID 2006 Conference, Valencia, Spain.

Improved microarray spot segmentation by combining two information channels. Margaritis T, Marias K, Kafetzopoulos D. Eng Med Biol Soc. 2006;1:5850-3.

Effect of Methotrexate on gene expression of Jurkat leukemic cells and comparison with the methilation inhibitor agent 5-aza-2-deoxycytidin Danilatou V, Tsiliki G, Aris V, et al. Haematologica-The Haematology Journal Volume: 93 Pages: 386-387

Microarray Image Denoising Using a Two-Stage Multiresolution Technique. Stefanou H., Margaritis T., Kafetzopoulos D., Marias K., Tsakalides P. Intl Conf IEEE Bioinf Biomed 2007; 383-389

Functional specifications of an integrated proteomics information management and analysis platform. Tsiknakis M, Grangeat P, Binz PA, Potamias G, Lisacek F, Gerfault L, Paulus C, Manakanatas D, Kritsotakis V, Kondylakis H, Perez M, Plexousakis D, Kaforou S, Kafetzopoulos D. Conf Proc IEEE Eng Med Biol Soc. 2007; p:6065-9.

A Capacitive Biosensor Based on Ultrathin Si Membranes. Tsouti, V., Goustouridis, D., Chatzandroulis, S., Normand, P., Andreakou, P., Ioannou, M., Kafetzopoulos, D., Boutopoulos, C., Zergioti, I., Tsoukalas, D., Hue, J. & Rousier, R. Sensors 2008; IEEE Pages: 223 - 226

Genome-wide analysis of gene expression profiles in overexpression or absence of Saccharomyces cerevisie Rad9 gene. Andreadis C, Margaritis T, Gkouskou Kafetzopoulos D, Alexandraki A. FEBS Journal Volume: 275 Pages: 117-117 Suppl. 1

Performance Validation of Microarray Analysis Methods. M. Zervakis, M. E. Blazadonakis, A. Mpati, D. Kafetzopoulos, V. Danilatou, M. Tsiknakis. 8th IEEE Intl. Conf. Bioinformatics & Bioengineering, 2008 Pages 1-6

A computational approach to a universal microarray RNA reference sample. G. Tsiliki, S. Kaforou, M. Kapsetaki, G. Potamias, D. Kafetzopoulos. 8th IEEE Intl. Conf. Bioinformatics & Bioengineering, 2008 Pages 1-7

A new gene expression signature related to the estrogen receptor status of breast tumors. E. Christodoulou, M. Ioannou, M. Kafousi, E. Sanidas, G. Papagiannakis, T. Margaritis, V. Danilatou, G. Tsiliki, S. Vassilaros, H. Kondylakis, D. Manakanatas, L. Koumakis, A. Kanterakis, M. Tsiknakis, A. Analyti, G. Potamias, D. D. Tsiftsis, E. Stathopoulos, D. Kafetzopoulos. 8th IEEE Intl. Conf. Bioinformatics & Bioengineering, 2008 Pages 1-7

Proteomic Based Identification of Cancer Biomarkers: The LOCCANDIA Integrated Platform. M. Kalaitzakis, V. Kritsotakis, P. Grangeat, C. Paulus, L. Gerfault, M. Perez, C. Reina, G. Potamias, M. Tsiknakis, D. Kafetzopoulos, P-A. Binz, 8th IEEE Intl. Conf. Bioinformatics & Bioengineering, 2008 Pages 1-7

An Integrated Clinico-Proteomics Information Management and Analysis Platform. M Kalaitzakis, V Kritsotakis, H Kondylakis, G Potamias, M Tsiknakis, D Kafetzopoulos. 21st IEEE International Symposium on Computer-Based Medical Systems 2008 Pages: 218-220

Supporting genotype-to-phenotype association studies with grid-enabled knowledge discovery workflows. Koumakis L, Moustakis V, Tsiknakis M, Kafetzopoulos D, Potamias G. IEEE Eng Med Biol Soc. Vol. 1, p.6958, 2009.

A semantically aware platform for the authoring and secure enactment of bioinformatics workflows. Tsiknakis M, Sfakianakis S, Zacharioudakis G, Koumakis L, Kanterakis A, Potamias G, Kafetzopoulos D. IEEE Eng Med Biol Soc. Vol. 1, p.5625-5628, 2009.

Multi-platform data integration in microarray analysis. Georgia Tsiliki, Michalis Zervakis, Marina Ioannou, Elias Sanidas, Eustathios Stathopoulos, George Potamias, Manolis Tsiknakis, and Dimitris Kafetzopoulos. 9th International Conference on Information Technology and Applications in Biomedicine, 2009. pp. 1-6

A Proposal for Gene Signature Integration. Blazadonakis, M.E.; Zervakis, M.E.; Kafetzopoulos, D.; 9th International Conference on Information Technology and Applications in Biomedicine, 2009. ITAB 2009. pp. 1 - 4

Integration of Biological Knowledge in the Mixture-of-Gaussians Analysis of Genomic Clustering. Sfakianakis S, Zervakis M, Tsiknakis M and Kafetzopoulos D. 10th International Conference on Information Technology and Applications in Biomedicine, 2010. pp. 1 - 4

The emerging concept of blood genomic profiling in childhood epilepsy. V. Danilatou, P. Vorgia, M. Pediaditis, M. Tsiknakis, D. Fotiadis, and D. Kafetzopoulos. 10th International Conference on Information Technology and Applications in Biomedicine, 2010. pp. 1 - 4

Revealing Disease Mechanisms via Coupling Molecular Pathways Scaffolds and Microarrays: A Study on the Wilm's Tumor Disease. Kanterakis, A., Moustakis, V., Kafetzopoulos, D., and Potamias, G. Biomedical Informatics & Intelligent Methods in the Support of Genomic Medicine, Artificial Intelligence Applications & Innovations 2009 workshop

Presentations in Conferences

Isolation and Characterization of Chitin Deacetylase from Mucor rouxii. Kafetzopoulos D, Martinou A and Bouriotis V. 5th International Conference "Chitin and Chitosan", Princeton, New Jersey, USA, 1991.

Isolation and characterization of chitin deacetylase from Mucor rouxii. Kafetzopoulos D, Martinou A, Tsigos I and Bouriotis V. International Conference "Enzymatic synthesis and modification of Carbohydrates", Coventry, UK, 1992.

Isolation and characterization of chitin deacetylase from Mucor rouxii. Kafetzopoulos D, Martinou A and Bouriotis V. International Conference "Forum for Applied Biotechnology", Brugge, Belgium, 1992.

cDNA cloning of chitin deacetylase from Mucor rouxii. Kafetzopoulos D, Thireos G, Vournakis J and Bouriotis V. 1st International Conference "Chitin Enzymology", Senigalia, Italy 1993.

Purification and properties of chitin deacetylase from Mucor rouxii. Kafetzopoulos D, Martinou A and Bouriotis V. 1st International Conference "Chitin Enzymology", Senigalia, Italy, 1993.

Chitin deacetylation by enzymatic means. Kafetzopoulos D, Martinou A, Tsigos I, Christodulidou A, Kavelaki P, Bouriotis V. 6th European Congress on Biotechnology, Florence, Italy,1993. (invited speaker)

Enzymatic deacetylation of chitin employing chitin deacetylases. Tsigos I, Martinou A, Varum K, Kafetzopoulos D, Christodoulidou A, Tzanodaskalaki M, and Bouriotis V. 6 th International Conference "CHITIN WORLD", Gdynia, Poland,1994.

On the biosynthesis of nodulation factors. Kafetzopoulos D and Spaink HP. 1o Συνέδριο "New Phytologist": Molecular Approaches to the Study of Plant-Microbe Symbiosis, York, UK, 1995. (invited speaker)

Lipo-chito-oligosaccharides (LCOs) as endogenous organogenesis signals of the plants. Kamst E, Kafetzopoulos D, Lugtenberg BJJ and Spaink HP. Keystone Symposia on Molecular & Cellular Biology, Signal transduction in plants, Hilton Head Island, South Carolina, USA, 1995.

Chitin deacetylases: Function and biological implications. Cloning and characterization of two new chitin deacetylases from Saccharomyces cerevisiae. Christodoulidou A, Martinou A, Kafetzopoulos D, Tsigos I, Thireos G, Bouriotis V. 2nd International Conference "Chitin Enzymology", Senigalia, Italy, 1996.

Chitin deacetylases and related activities. Kafetzopoulos D, Christodoulidou A, Tsigos I, Thireos G, Spaink HP, Bouriotis V. 6th International Conference "Fungal Spore Wall", Κοστάντζα, Γερμανία, 1996. (invited speaker)

Enzymatic deacetylation of chitin. Tsigos I, Christodoulidou A, Martinou A, Tzanodaskalaki M, Kafetzopoulos D, and Bouriotis V. 7th International Conference "Chitin and Chitosan", Lyon, France, 1997.

Chitin enzymology: Targets and models for the development of biotechnological applications. Kafetzopoulos D. International Marine Biotechnology Workshop, Oldenburg, Germany, 2000. (invited speaker)

Molecular Biology of insect chitin synthases. Kapsetaki M, Gagou ME, Turberg A, Kafetzopoulos D. 8th International Conference "Chitin and Chitosan", Yamaguchi, Japan, 2000.

Molecular Biology of Insect Chitin Synthases. Kapsetaki M, Gagou ME, Turberg A and Kafetzopoulos D. 3rd International Conference "Chitin Enzymology", Senigallia, Italy, 2001.

Management of scientific research results - Example of a medicinal target. Kafetzopoulos D. "Patents in biotechnology" Conference, Heraklion, 2002. (invited speaker)

From human genome to personalized medicine. Kafetzopoulos D. 8th Panhellenic Congress on Surgical Oncology, Athens, 2003 (invited speaker)

Time resolved Schlieren study of sub-ps and ns laser transfer of biomaterials Zergioti I., Karaiskou, A., Papazoglou, D., Fotakis, C., Kapsetaki, M., Kafetzopoulos, D. E-MRS, Strasbourg, France, 2004

Nanobiotechnology: Reverse Engineering of Life. Kafetzopoulos, D. 2nd European Technology Transfer Days, Germany, 2004 (invited speaker)

Post-genomic Approaches to New Pesticides: The example of insect chitin synthases, Kafetzopoulos, D. 1st International Conference of Biotechnology in Greece, Athens 2004, (invited speaker)

Photochemical Laser applications in Biological Molecules. Kafetzopoulos D. Laser Olympics 2004, Athens 2004, (invited speaker)

Microarrays and New Genes in Cancer. Kafetzopoulos D. 5th Panhellenic Conference on Indicators & Targeted Cancer Therapy, Athens 2004, (invited speaker)

From genome to personalized genetic medicine. Kafetzopoulos D. 3rd Training and Specialization Seminar MultiMine "Mining Knowledge with emphasis on medical applications", Chania 2004 (invited speaker)

From genome to personalized medicine. Kafetzopoulos D. Multidisciplinary Congress, Faculty of Medicine, University of Crete, Heraklion (2005) (invited speaker)

Genome and breast cancer. Kafetzopoulos D. Early breast cancer: Minimal Treatment, Heraklion (2005) (invited speaker).

Biomedical Informatics as a means for achieving Systems Biology approaches to the understanding and treatment of cancer. D. Kafetzopoulos, S. Stathopoulos, M. Kafousi, E. Sanidas, S. Vassilaros, K. Marias, G. Potamias, A. Analyti and M. Tsiknakis. 7th Hellenic European Research on Computer Mathematics and its Applications, 2005, Athens, Greece

Mining Gene Regulatory Networks and Microarray Data: The MinePath Approach. Kanterakis, D. Kafetzopoulos, V. Moustakis, G. Potamias. 18th European Conference on Artificial Intelligence

Mining Gene Regulatory Profiles and Gene Regulatory Networks: Identification of Phenotype-specific Molecular Mechanisms. Kanterakis, D. Kafetzopoulos, V. Moustakis, G. Patamias. 5th Hellenic Conference on Artificial Intelligence

Advancing Clinico-Genomic Research Trials via Integrated Knowledge Discovery Operations. G. Potamias, M. Tsiknakis, V. Papoutsidis, A. Kanterakis, K. Marias, D. Kafetzopoulos. 20th International Congress of the European Federation of Medical Informatics 2006 Netherlands.

Microarrays: Quality counts. T. Margaritis, K. Marias, M. Kapsetaki, G. Papagianakis, D. Kafetzopoulos. Proceedings of the 2nd International Advanced Research Workshop on In Silico Oncology, 2007 Kolymbari, Greece

Mining Interesting Clinico-Genomic Associations: The HealthObs Approach. G. Potamias, L. Koumakis, A. Kanterakis, V. Moustakis, D. Kafetzopoulos, M. Tsiknakis. Proceedings of the 4th International Federation for Information Processing Conference on Artificial Intelligence Applications & Innovations 2007, Athens, Greece.

Decomposition of Gene Regulatory Networks into Functional Paths and their Matching with Microarray Gene Expression Profiles. Kanterakis, A., Kafetzopoulos, D., Moustakis, V., and Potamias, G. 6th European Symposium on Biomedical Engineering 2008, Chania, Greece, Symposium Program.

Post Genomic Analysis of Complex Diseases: Examples from Brain Cancer Research. D. Kafetzopoulos. BioVision Alexandria 2010, New Life Sciences: Future Prospects- Brain Aging-Brain Advancing, 2010, Alexandria Egypt (invited speaker)

Patents

Purified chitin deacetylase. Kafetzopoulos D, Martinou A, Bouriotis V, and Vournakis JJ. International Publication Number: WO9307262, (15-APR-1993). Patents: US 5,219,749 \ EP 0610320 \ CA 2,120,328 AU 669,676 \ JP 7,231,787 \ ?? 286, 078.

DNA encoding chitin deacetylase. Thireos G and Kafetzopoulos D. International Publication Number: WO9413815, (23-JUN-1994). Patents: EP 673,425 \ CA 2,151,257 \ AU 5,698,494 AU 663,991 \ KP 702,300 \ US 5,525,502 \ US 6,297,040 \ US 6,004,795. (The license for the technology of 1 and 2 for the European countries has also been purchased by the Belgian company Kitozyme S. A., Liege, while for other countries the license has been purchased by the American company Marine Polymer technology Inc. Danvers, MA)

DNA encoding an arthropod chitin synthase. Thireos G, and Kafetzopoulos D. International Publication Number: WO9853053, (26-NOV-1998) Patents and pending applications: US 09 230,041 EP 983,366 \ JP 549954/98 \ NO 19990244 \ AU8019098.

An inhibitor of Arthropod Chitin Synthase. Thireos G, and Kafetzopoulos D. European patent Application 03 005 489.4 (17- ΜΑΡ -03) (The license right to the technology of 3 and 4 is now a property of the German chemical industry BAYER AG, Leverkusen)

Fabrication of biopolymer patterns by means of laser transfer. Fotakis K, Thireos G, Zergioti I, Kafetzopoulos D. Patent: 1004059 (15-NOV-2002). International patent Application PCT / EP 02/14761 (24- DEC -02)

Biosensor by monitoring magnetically induced capacitance changes. D. Kafetzopoulos, P. Andreakou, C. Boutopoulos, I. Zergioti, S. Chatzandroulis, P. Normand, D. Tsoukalas. Patent application GR20080100140, 05/03/2008

Scientific articles and other publications

ERCIM Working Group on Biomedical Informatics. M. Tsiknakis and D. Kafetzopoulos ERCIM News, Vol. 60, pp. 15-16, 2005

Biomedical Informatics in Support of Individualized Medicine. S. Orphanoudakis, D. Kafetzopoulos and M. Tsiknakis. ERCIM News, Vol. 60, pp. 12-14, 2005

The Prognochip Project: Transcripromics and Biomedical Informatics for the Classification and Prognosis of Breast Cancer. D. Kafetzopoulos. ERCIM News, Vol. 60, pp. 27-28, 2005

Biomedical Imaging for Enhanced Genetic Data Analysis. T. Margaritis, K. Marias, M. Tsiknakis and D. Kafetzopoulos. ERCIM News, Vol. 60, pp. 54-55, 2005

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