imbb logo for mobile
 

Structural Instability Tuning as a Regulatory Mechanism in Protein-Protein Interactions

Structural Instability Tuning as a Regulatory Mechanism in Protein-Protein Interactions

The team of Prof. Economou in collaboration with the Kalodimos lab (Rutgers U.) reveals a novel regulatory mechanism in protein-protein interactions. Chen et al show that the interaction of a chaperone with its substrate is mediated by finely tuned structural instability and is coupled to molecular mimicry.