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bHLH-O proteins are crucial for Drosophila neuroblast self-renewal and mediate Notch-induced overproliferation

bHLH-O proteins are crucial for Drosophila neuroblast self-renewal and mediate Notch-induced overproliferation

Work from IMBB has uncovered a role for bHLH-O (a.k.a. Hes) proteins Dpn and E(spl) in neural stem cell maintenance in Drosophila. By exerting an anti-differentiation activity they ensure long-term proliferation, which is needed to produce the myriad of neural cells. However, aberrant cell signalling that leads to bHLH-O overexpression can cause pathological over-proliferation of neural stem cells. Zacharioudaki et al, Development 2012.