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Spyros Georgatos

Spyros Georgatos

Collaborating Faculty Member Prof. of Biological Chemistry, Medical School, University of Ioannina
Email address
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Phone
+30 26510 0844, +30 26510 07565
  
+30 2811392167
Fax
+30 2651 007077

Biography
Spyros D. Georgatos is a member of BRI-FORTH since 2002. He holds a Medical Degree from the University of Athens, Greece (1980) and a Ph.D. in Biology from Yale University, USA (1985). He post-docked at Caltech and Rockefeller University in the US and served as a group leader in the Cell Biology Program of the European Molecular Biology Laboratory (EMBL) in the period 1990-1996. In 1999 he was elected an EMBO member, while serving as an Associate Professor at the University of Crete, School of Medicine, Greece. He is Head of the Laboratory of Biology at the Ioannina University, School of Medicine. Prof. Georgatos has published one book and numerous research articles (over 3.000 citations). His recent interests include stem cell differentiation and division, as it relates to nuclear structure and function. His administrative work includes the establishment of one of the first Graduate Programs in Cell and Molecular Biology in Greece (1998), service at the Scientific Board of the Hellenic Pasteur Institute (2001-2004) and management of several research grants.

Markaki Y, Christogianni A, Politou AS, Georgatos SD. (2009) Phosphorylation of histone H3 at threonine-3 is part of a combinatorial pattern that marks and configures mitotic chromatin. J. Cell Sci. 122:2809-19.

Dialynas GK, Terjung S, Brown JP, Aucott RL, Baron-Luhr B, Singh PB, Georgatos SD. (2007) Plasticity of HP1 proteins in mammalian cells. J Cell Sci. 120:3415-24.

Dialynas GK, Makatsori D, Kourmouli N, Theodoropoulos PA, McLean K, Terjung S, Singh PB, Georgatos SD. (2006) Methylation-independent binding to histone H3 and cell cycle-dependent incorporation of HP1beta into heterochromatin. J Biol Chem. 281:14350-60.

Makatsori D, Kourmouli N, Polioudaki H, Shultz LD, McLean K, Theodoropoulos PA, Singh PB, Georgatos SD. (2004) The inner nuclear membrane protein LBR forms distinct microdomains and links epigenetically marked chromatin to the inner nuclear envelope. J. Biol. Chem. 279:25567-73.

Kourmouli N, Theodoropoulos PA, Dialynas G, Bakou A, Politou AS, Cowell IG, Singh PB, Georgatos SD. (2000) Dynamic associations of Heterochromatin Protein 1 with the nuclear envelope. EMBO J. 19: 6558-68.

Publications (after 2000)

Giannios I, Chatzantonaki E, Georgatos S. (2017) Dynamics and Structure-Function Relationships of the Lamin B Receptor (LBR). PLoS One.12(1):e0169626.

Christogianni A, Chatzantonaki E, Soupsana K, Giannios I, Platania A, Politou AS, Georgatos S. (2017) Heterochromatin remodeling in embryonic stem cells proceeds through stochastic de-stabilization of regional steady-states. Biochim Biophys Acta. 1860(6):661-673.

Papamokos GV, Tziatzos G, Papageorgiou DG, Georgatos SD, Politou AS, Kaxiras E. (2012) Structural role of RKS motifs in chromatin interactions: a molecular dynamics study of HP1 bound to a variably modified histone tail. Biophys J. 102(8):1926-33.

Liokatis S, Edlich C, Soupsana K, Giannios I, Panagiotidou P, Tripsianes K, Sattler M, Georgatos SD, Politou AS. (2012) Solution structure and molecular interactions of lamin B receptor Tudor domain. J Biol Chem. 287(2):1032-42.

Markaki Y., Christogianni A., Politou A.S., Georgatos, S.D. (2009) Phosphorylation of histone H3 at threonine-3 is part of a combinatorial pattern that marks and configures mitotic chromatin. J. Cell Sci., 122:2809-2819.
    
Akoumianaki T, Kardassis D, Polioudaki H, Georgatos SD, Theodoropoulos PA. (2009) Nucleocytoplasmic shuttling of soluble tubulin in mammalian cells. J Cell Sci., in press.

Georgatos SD, Markaki Y, Christogianni A, Politou AS. (2009) Chromatin remodeling during mitosis: a structure-based code? Front Biosci., 14:2017-27 (invited review).

Dialynas GK, Terjung S, Brown JP, Aucott RL, Baron-Luhr B, Singh PB, Georgatos SD. (2007) Plasticity of HP1 proteins in mammalian cells. J Cell Sci., 120:3415-24.

Ritou E, Bai M, Georgatos SD. (2007) Variant-specific patterns and humoral regulation of HP1 proteins in human cells and tissues. J Cell Sci., 120:3425-35.

Michalakis J, Georgatos SD, de Bree E, Polioudaki H, Romanos J, Georgoulias V, Tsiftsis DD, Theodoropoulos PA. (2007) Short-term exposure of cancer cells to micromolar doses of paclitaxel, with or without hyperthermia, induces long-term inhibition of cell proliferation and cell death in vitro. Ann Surg Oncol., 14:1220-8.

Dialynas GK, Makatsori D, Kourmouli N, Theodoropoulos PA, McLean K, Terjung S, Singh PB, Georgatos SD. (2006) Methylation-independent binding to histone H3 and cell cycle-dependent incorporation of HP1beta into heterochromatin. J Biol Chem., 281:14350-60.

Michalakis J, Georgatos SD, Romanos J, Koutala H, Georgoulias V, Tsiftsis D, Theodoropoulos PA. (2005) Micromolar taxol, with or without hyperthermia, induces mitotic catastrophe and cell necrosis in HeLa cells. Cancer Chemother Pharmacol., 56:615-22.

Makatsori D, Kourmouli N, Polioudaki H,  Shultz LD,  McLean K, Theodoropoulos PA, Singh PB, Georgatos SD. (2004) The inner nuclear membrane protein LBR forms distinct microdomains and links epigenetically marked chromatin to the nuclear envelope. J Biol Chem., 279:25567-25573.

Polioudaki H, Markaki G,  Kourmouli N, Dialynas G, Theodoropoulos PA, Singh PB, Georgatos SD. (2004) Mitotic phosphorylation of histone H3 at threonine 3. FEBS Lett.  560:39-44.

Singh PB, Georgatos SD (2002)  HP1: facts, open questions, and speculation. J. Struct. Biol. 140:10-16 (invited review).

Polioudaki H, , Drosou V, Bakou A, Theodoropoulos PA, Singh PB, Giannakouros T, Georgatos SD (2001) Histones H3/H4 form a tight complex with the inner nuclear membrane protein LBR and heterochromatin protein 1. EMBO Rep. 2:920-925.

Georgatos SD (2001) The inner nuclear membrane: simple, or very complex?  EMBO J.,  20:2989-2994(invited review).

Kourmouli N, Dialynas G, Petraki C, Pyrpasopoulou A,  Singh PB, Georgatos SD, Theodoropoulos PA (2001) Binding of Heterochromatin Protein 1 to the nuclear envelope is regulated by a soluble form of tubulin. J. Biol. Chem., 276:13007-1314.

Kourmouli N, Theodoropoulos PA, Dialynas G, Bakou A, Politou AS, Cowell IG, Singh PB, Georgatos SD (2000) Dynamic associations of Heterochromatin Protein 1 with the nuclear envelope. EMBO J., 19: 6558-6568.