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Theodore Fotsis

Theodore Fotsis

Group Leader and Director Prof. of Biological Chemistry, Medical School, University of Ioannina
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Phone
+30 26510 07560, +30 2811392169
Fax
+30 2651 007077
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Dr Fotsis has graduated from the Medical School of the University of Athens and obtained his PhD degree in Helsinki, Finland. He has worked as post-doc in University College Galway, Ireland and as a senior scientist in the University of Heidelberg and the German Cancer Research Center (DKFZ) in Heidelberg, Germany. Since 1995, he is a staff member of the Medical School of the University of Ioannina and since 2007 has a joint appointment in the IMBB-BR of FORTH in Ioannina. He has long-standing experience in the molecular mechanisms of tumour angiogenesis and endothelial cell signalling. Currently he is interested also in stem cell biology and regenerative medicine focusing on regeneration of mesodermal tissues including vessels and ligaments. He has published 85 papers in peer-reviewed journals, which have received over 8200citations (h index of 42). He is holder of the Gerhard-Domagk-Prize of Oncology, Germany, 1995. He served as representative of Greece in EMBC/EMBL (2004-2010) and in FP7-HEALTH Committee (2008-2010) and was a member of the National Council of Research and Technology of Greece (2005-2007). Since 2010 he is a member of the National Scientific Council of Biosciences and was recently appointed as National Representative in the Health, demographic change and wellbeing Horizon 2020 committee.

Karali E, Bellou S, Stellas D, Klinakis A, Murphy C, Fotsis T. (2014) VEGF Signals through ATF6 and PERK to Promote Endothelial Cell Survival and Angiogenesis in the Absence of ER Stress.  Molecular Cell 54: 559-72.

Kostaras E, Sflomos G, Pedersen NM, Stenmark H, Fotsis T, Murphy C. (2013) SARA and RNF11 Interact with Each Other and ESCRT-0 Core Proteins and Regulate Degradative EGFR Trafficking. Oncogene 32: 5220-32.

Kyrkou A, Soufi M, Bahtz R, Ferguson C, Bai M, Parton RG, Hoffmann I, Zerial M, Fotsis T, Murphy C. (2013) RhoD participates in the regulation of cell-cycle progression and centrosome duplication. Oncogene 32: 1831-42.

Sflomos G, Kostaras E, Panopoulou E, Pappas N, Kyrkou A, Politou AS, Fotsis T, Murphy C. (2011) ERBIN is a novel SARA-interacting Protein: Competition between SARA and SMAD2/3 for binding to ERBIN. J Cell Sci. 124: 3209-22.

Bellou S, Hink MA, Bagli E, Panopoulou E, Bastiaens PI, Murphy C, Fotsis T. (2009) VEGF Auto-regulates its Proliferative and Migratory ERK1/2 and p38 MAPK Cascades by Enhancing the Expression of DUSP1 and DUSP5 Phosphatases in Endothelial Cells. Am J Physiol Cell Physiol  297: C1477-89.

·       Vlaikou AM, Kouroupis D, Sgourou A, Markopoulos GS, Bagli E, Markou M, Papadopoulou Z, Fotsis T, Nakos G, Lekka ME, Syrrou M. Mechanical stress affects methylation pattern of GNAS isoforms and osteogenic differentiation of hAT-MSCs. Biochim Biophys Acta. 2017, 1864(8):1371-1381.

·       Kyrkou A, Stellas D, Syrrou M, Klinakis A, Fotsis T, Murphy C. Generation of human induced pluripotent stem cells in defined, feeder-free conditions. Stem Cell Res. 2016,17(2):458-460.

·       Basagiannis D, Zografou S, Murphy C, Fotsis T, Morbidelli L, Ziche M, Bleck C, Mercer J, Christoforidis S. VEGF induces signalling and angiogenesis by directing VEGFR2 internalisation through macropinocytosis. J Cell Sci. 2016, 129(21):4091-4104.

·       Kouroupis D, Kyrkou A, Triantafyllidi E, Katsimpoulas M, Chalepakis G, Goussia A, Georgoulis A, Murphy C, Fotsis T. Generation of stem cell-based bioartificial anterior cruciate ligament (ACL) grafts for effective ACL rupture repair. Stem Cell Res. 2016, 17(2):448-457.

·       Mantzaris MD, Bellou S, Skiada V, Kitsati N, Fotsis T, Galaris D. Intracellular labile iron determines H2O2-induced apoptotic signaling via sustained activation of ASK1/JNK-p38 axis. Free Radic Biol Med. 2016, 97:454-65.

·       Tsolis KC, Bagli E, Kanaki K, Zografou S, Carpentier S, Bei ES, Christoforidis S, Zervakis M, Murphy C, Fotsis T, Economou A. Proteome Changes during Transition from Human Embryonic to Vascular Progenitor Cells. J Proteome Res. 2016 Jun 3;15(6):1995-2007.

·       Sanchez-Duffhues G, Fotsis T, ten Dijke P. Signal Transduction: Gain of Activin Turns Muscle into Bone. Curr Biol. 2015, 25(23):R1136-8.

·       Yang J, AlTahan AM, Hu D, Wang Y, Cheng PH, Morton CL, Qu C, Nathwani AC, Shohet JM, Fotsis T, Koster J, Versteeg R, Okada H, Harris AL, Davidoff AM. The role of histone demethylase KDM4B in Myc signaling in neuroblastoma. Journal of National Cancer Institute 2015, 107(6):djv080. 

·       Karali E., Bellou S., Stellas D., klinakis A., Murphy C, and Fotsis T. VEGF Signals through ATF6 and PERK to Promote Endothelial Cell Survival and Angiogenesis in the Absence of ER Stress. Molecular Cell 2014, 54: 559-72.

·       Kostaras E., Pedersen NM, Stenmark H, Fotsis T and Murphy C.  SARA and RNF11 at the crossroads of EGFR signaling and trafficking. Methods in Enzymology 2014; 535:225-47.

·       Bellou S, Pentheroudakis G, Murphy C, and Fotsis T. Anti-angiogenesis in cancer therapy: Hercules and Hydra. Cancer Letters 2013, 338: 219-28.

·       Kostaras E., Sflomos G, Pedersen NM, Stenmark H, Fotsis T* and Murphy C*.  SARA and RNF11 Interact with Each Other and ESCRT-0 Core Proteins and Regulate Degradative EGFR Trafficking. Oncogene 2013, 32 (44): 5220-32. *These authors contributed equally to this work.

·       Kyrkou A, Soufi M, Bahtz R, Ferguson C, Bai M, Parton RG, Hoffmann I, Zerial M, Fotsis T, Murphy C. The RhoD to centrosomal duplication. Small GTPases 2013, 4 (2) [Epub ahead of print].

·       Kyrkou A, Soufi M, Bahtz R, Ferguson C, Bai M, Parton RG, Hoffmann I, Zerial M, Fotsis T, Murphy C. RhoD participates in the regulation of cell-cycle progression and centrosome duplication. Oncogene. 2013, 32 (14): 1831-42.

·       Bellou S, Karali E, Bagli E, Al-Maharik N, Morbidelli L, Ziche M, Adlercreutz H, Murphy C, FotsisT. The isoflavone metabolite 6-methoxyequol inhibits angiogenesis and suppresses tumor growth. Mol Cancer 2012 May 14;11(1):35. [Epub ahead of print]

·       Stoyianni A, Goussia A, Pentheroudakis G, Siozopoulou V, Ioachim E, Krikelis D, Golfinopoulos V, Cervantes A, Bobos M, Fotsis T, Bellou S, Fountzilas G, Malamou-Mitsi V, Pavlidis N. Immunohistochemical study of the epithelial-mesenchymal transition phenotype in cancer of unknown primary: incidence, correlations and prognostic utility. Anticancer Res. 2012, 32(4):1273-81.

·       G.Sflomos, E.Kostaras, E. Panopoulou, N. Pappas, A.Kyrkou, A. Politou, T Fotsis & C.Murphy. ERBIN is a novel SARA-interacting Protein: Competition between SARA and SMAD2/3 for binding to ERBIN, J Cell Sci. 2011, 124: 3209-22.

·       Moumtzi SS, Roberts LM, Joyce T, Euagelidou M, Probert L, Frillingos S, Fotsis T, and Pintzas A. Gene expression profile associated with oncogenic RAS-induced senenscence, cell death and transforming properties in human cells. Cancer Invest 2010, 28: 563-587.

·       Bellou S, Mark A Hink, AM, Bagli E, Panopoulou E, Bastiaens PIH, Murphy C, Fotsis T. VEGF Auto-regulates its Proliferative and Migratory ERK1/2 and p38 MAPK Cascades by Enhancing the Expression of DUSP1 and DUSP5 Phosphatases in Endothelial Cells. Am J Physiol Cell Physiol 2009 297: C1477-89.

·       Kardassis D, Murphy C, Fotsis T, Moustakas A and Stournaras C. Control of TGFβ signal transduction by small GTPases. FEBS J 2009, 276: 22947-65.

·       Goulas V, Exarchou V, Troganis AN, Psomiadou E, Fotsis T, Briasoulis E, Gerothanassis IP. Phytochemicals in olive-leaf extracts and their antiproliferative activity against cancer and endothelial cells. Mol Nutr Food Res. 2009, 53: 600-608.

·       Karavasilis V, Malamou-Mitsi V, Briasoulis E, Tsanou E, Kitsou E, Kalofonos H, Fountzilas G, Fotsis T, Pavlidis N. Matrix metalloproteinases in carcinoma of unknown primary. Cancer. 2005, 104(10): 2282-7.

·       Karavasilis V, Malamou-Mitsi V, Briasoulis E, Tsanou E, Kitsou E, Kalofonos H, Fountzilas G, Fotsis T, Pavlidis N. Angiogenesis in cancer of unknown primary: clinicopathological study of CD34, VEGF and TSP-1. BMC Cancer 2005, 5(1): 25.

·       Panopoulou E, Murphy C, Rasmussen H, Bagli E, Rofstad EK, Fotsis T. Activin A suppresses neuroblastoma xenograft tumor growth via antimitotic and antiangiogenic mechanisms. Cancer Res. 2005, 65(5): 1877-86.

·       Adlercreutz H, Kiuru P, Rasku S, Wahala K, Fotsis T. An isotope dilution gas chromatographic-mass spectrometric method for the simultaneous assay of estrogens and phytoestrogens in urine. J Steroid Biochem Mol Biol. 2004, 92(5): 399-411.

·       Bagli E, Stefaniotou M, Morbidelli L, Ziche M, Psillas K, Murphy C, Fotsis T. Luteolin inhibits vascular endothelial growth factor-induced angiogenesis; inhibition of endothelial cell survival and proliferation by targeting phosphatidylinositol 3'-kinase activity. Cancer Res. 2004, 64(21): 7936-46.

·       Roussou I, Lambropoulos I, Pagoulatos GN, Fotsis T, Roussis IG. Decrease of heat shock protein levels and cell populations by wine phenolic extracts. J Agric Food Chem. 2004, 52(4): 1017-24.

·       Hatzi, E., Murphy, C., Zoephel, A., Ahorn, A., Tontsch, U., Bamberger A-M., Yamauchi-Takihara, Y., Schweigerer, L., and Fotsis, T.  N-myc Oncogene Overexpression Down-Regulates Leukemia Inhibitory Factor in Neuroblastoma. Eur. J. Biochem. 2002, 269: 3732-3741.

·       Hatzi, E., Murphy, C., Zoephel, A., Rasmussen, H., Morbidelli, L., Ahorn, A., Kunisada, K., Tontsch, U., Klenk, M., Yamauchi-Takihara, Y., Ziche, M., Rofstad, E.K., Schweigerer, L., and Fotsis, T. N-myc Oncogene Overexpression Down-Regulates IL-6; Evidence that IL-6 Inhibits Angiogenesis and Suppresses Neuroblastoma Tumour Growth. Oncogene 2002, 16: 3552-3561.

·       Panopoulou, E., Gillooly, D.J., Jeffrey, J.L., Zerial, M., Stenmark, H., Murphy, C*., and Fotsis, T*. Early Endosomal Regulation of Smad-Dependent Signaling in Endothelial Cells. J. Biol. Chem. 2002, 277: 18046-18052.*These authors contributed equally to this work

·       Kotanidou, A., Xagorari, A., Bagli, E., Kitsanta, P., Fotsis, T., Papapetropoulos, A., and Roussos, C.. Luteolin reduces LPS-induced lethal toxicity and expression of pro-inflamatory molecules in mice. Am. J. Resp. Crit. Care Med. 2002, 165: 818-823.

·       Murphy, C., Saffrich, R., Olivo-Marin, J-C., Giner, A., Ansorge, W., Fotsis, T., and Zerial, M. Dual function of rhoD in vesicular movement and cell motility. Eur. J. Cell Biol. 2001, 80: 391-398.

·       inhibits an endotoxin-stimulated phosphorylation cascade and proinflammatory cytokine production in macrophages. J. Pharmacol. Exp. Therap. 2001, 296: 181-187.

·       Breit, S., Ashman, K., Wilting, J., Rössler, J., Hatzi, E., Fotsis, T*., and Schweigerer, L*. The N-myc oncogene in human neuroblastoma cells: down-regulation of an angiogenesis inhibitor identified as activin A. Cancer Res. 2000, 60: 4596-4601.*These authors contributed equally to this work

·       Breit, S., Rössler, J., Fotsis, T., and Schweigerer, L. N-myc down-degulates activin A.   Biochem. Biophys. Res. Commun. 2000, 274: 405-409.

·       Fotsis, T., Breit, S., Lutz, W., Rössler, J., Hatzi, E., Schwab, M., and Schweigerer, L. Down-regulation of endothelial cell growth inhibitors by enhanced MYCN oncogene expression in human neuroblastoma cells. Eur. J. Biochem. 1999, 263: 757-764.

·       Gong, H., Zolter, F., von Recklinghausen, G., Rossler, J., Breit, S., Havers, W., Fotsis, T., Schweigerer, L. Arginine deiminase inhibits cell proliferation by arresting cell cycle and inducing apoptosis. Biochem. Biophys. Res. Commun. 1999, 261: 10-14.

·       Pappa, A., Seferiadis, K., Fotsis, T., Shevchenko, A., Marselos, M., Tsolas, O., Messinis, I.E. Purification of a candidate gonodotrophin surge attenuating factor from human follicular fluid. Hum. Reprod. 1999, 14: 1449-1456.

·       Adlercreutz, H., and Fotsis, T. Comment on altered hydroxylation of estrogen in patients with postmenopausal osteopenia. J. Clin. Endocrinol. Metab. 1998, 83: 4170-4171.

·       Kruse, F.T., Joussen, A.M., Fotsis, T., Schweigerer, L., Rohrschneider, K., Volcker, H.E. Inhibition of neovascularization of the eye by dietary factors exemplified by isoflavonopids. Ophthalmologe 1997, 94: 152-156.

·       Fotsis, T., Pepper, M.S., Aktas, E., Breit, S., Rasku, S., Adlercreutz, H., Wähälä, K., Montesano, R., and Schweigerer, L. Flavonoids, dietary-derived inhibitors of cell proliferation and in vitro angiogenesis. Cancer Research 1997, 57: 2916-2921.

·       Wilm, M., Shevchenko, A., Houthaeve, T., Breit, S., Schweigerer, L., Fotsis, T., and Mann, M. Femtomole sequencing of proteins from polyacrylamide gels by nano-electrospray mass spectrometry. Nature 1996, 379: 466-469.

·       Mazur, W., Fotsis, T., Wähälä, K, Ohjala, S., Salakka, A., and Adlercreutz, H. Isotope dilute gas chromatographic-mass spectrometric method for the determination of isoflavonoids, coumestrol, and lignans in food samples. Analytical Biochemistry 1996, 233: 169-180.

·       Pipili-Synetos, E., Papageorgiou, A., Sakkoula, E., Sotiropoulou, G., Fotsis, T., Karakiulakis, G., and Maragoudakis, M.E. Inhibition of angiogenesis, tumour growth and metastasis by the NO-releasing vasodilators, isosorbide mononitrate and dinitrate. Br. J. Pharmacol. 1995, 116: 1829-1834.

·       Musey, P.I., Adlercreutz, A., Gould, K.G., Collins, D.C., Fotsis, T., Bannwart, C., Mäkelä, T., Wähälä, K., Brunow, G., and Hase, T. Effect of diet on lignans and isoflavonoids phytoestrogens in chimpanzees. Life Sciences 1995, 57: 655-664.

·       Lonning, P.E., Helle, S-I., Johannessen, D.C., Adlerctreutz, H., Lien, E.A., Tally, M., Ekse, D., Fotsis, T., Anker, G.B., and Hall, K. Relations between sex hormones, sex hormone binding globulin, insulin-like growth factor-1 and insulin-like growth factor binding protein-1 in post-menopausal breasr cancer patients. Clinical Endocrinology 1995, 42: 23-30.

·       Lonning, P.E., Johannessen, D.C., Lien, E.A., Ekse, D., Fotsis, T., and Adlercreutz, H. Influence of tamoxifen on sex hormones, gonadotrophins and sex hormone binding globulin in postmenopausal brease cancer patients. J. Steroid Biochem. Mol. Biol. 1995, 52: 491-496.

·       Fotsis, T., Pepper, M., Adlercreutz, H., Hase, T., Montesano, R., and Schweigerer, L. Genistein, a dietary ingested isoflavonoid, inhibits cell proliferation and in vitro angiogenesis. J. Nutr. 1995, 125: 790S-797S.

·       Adlercreutz, H.T., Goldin, B.R., Gorbach, S.L., Höckerstedt, K.A.V., Watanabe, S., Hämäläinen, E.K., Markkanen, M.H., Mäkelä, T.H., Wähälä, K.T., Hase, T.A. and Fotsis, T. Soybean phytoestrogen intake and cancer risk. J. Nutr. 1995, 125: 757S-770S.

·       Adlercreutz, H., Fotsis, T., Kurzer,M., Wähälä, K., Mäkelä,T., and Hase, T. Isotope dilution gas chromatographic-mass spectrometric method for the determination of unconjugated lignans and isoflavonoids in human feces, with preliminary results in omnivorous and vegetarian women. Analytical Biochemistry 1995, 225: 101-108.

·       Adlercreutz,H., van der Wildt, J., Kinzel, J., Attala, H., Wähälä, K., Mäkelä,T., Hase, T., and Fotsis, T. Lignan and isoflavonoid conjugates in human urine. J. Steroid Biochem. Mol. Biol. 1995, 52: 97-103.

·       Adlercreutz, H., Fotsis, T., Watanabe, S., Lampe, J.,Wähälä, K., Mäkelä,T., and Hase, T. Determination of lignans and isoflavonoids in plasma by isotope dilution gas chromatograohy-mass spectrometry. Cancer Detection and Prevention 1994, 18: 259-271.

·       Adlercreutz,H., Gorbach,S.L., Goldin, B.R., Woods, M.N., Dwyer, J.T., Höckerstedt, K.A.V., Wähälä, K.T., Hase, T., Hämäläinen, E.K., and Fotsis, T. Diet and urinary profile in various populations. A preliminary report. Polycyclic Aromatic Compounds, 1994, 6: 261-273.

·       Fotsis, T., Zhang, Y., Pepper, M.S., Adlercreutz, H., Montesano, R., Nawroth, P.P., and Schweigerer, L. The endogenous oestrogen metabolite 2-methoxyestradiol inhibits angiogenesis and suppresses tumour growth. Nature 1994, 368: 237-239.

·       Johannessen, G. C, Adlerceutz, H., Fotsis, T., and Lonning, E. Plasma and urinary oestrogens in breast cancer patients on treatmnet with 4-hydroxyandrostenedione. Brit. J. Cancer 1993, 68: 393-398.

·       Adlercreutz, H., Fotsis, T., Lampe, J., Wähälä, K., Mäkelä, T., Brunow, G., and Hase, T. Quantitative determination of lignans and isoflavonoids in plasma of omnivorous and vegetarian women by isotope dilution gas chromatography-mass spectrometry. Scand. J. Clin. Lab. Invest. 1993, 53 (Suppl 215): 5-18.

·       Fotsis, T., Pepper, M., Adlercreutz, H., Fleischmann, G., Hase, T., Montesano, R. and Schweigerer, L. Genistein, a dietary-derived inhibitor of in vitro angiogenesis. Proc. Natl. Acad. Sci. 1993, 90: 2690-2694.

·       Schweigerer, L., Christeleit, K., Fleischmann, G., Adlercreutz, H., Wähälä, K., Hase, T., Schwab, M., Ludwig, R., and Fotsis, T. Identification in human urine of a natural growth inhibitor for cells derived from solid pediatric tumours. Eur. J. Clin. Invest. 1992, 22: 260-264.

·       Schweigerer, L., and Fotsis, T. Angiogenesis and angiogenesis inhibitors in pediatric diseases. Eur. J. Pediatr. 1992, 151: 472-476.

·       Schweigerer. L., and Fotsis, T. Erhöhte Expression des MYCN Ongogens in humanen Neuroblastomzellen und mögliche, neue Therapie-Ansätze. Klin. Pädiatr. 1991, 203: 319-322.

·       Adlercreutz, H., Honjo, H., Higashi, A., Fotsis, T., Hämäläinen, E., Hasegawa, T., and Okada, H. Urinary excretion of lignans and isoflavonoid phytoestrogens in Japanese men and women consuming a traditional Japanese diet. Am. J. Clin. Nutr. 1991, 54: 1093-1100.

·       Adlercreutz, H., Fotsis, T., Bannwart, C., Wähälä, K., Brunow, G., and Hase, T. Isotope dilution gas chromatographic-mass spectrometric method for the determination of lignans and isoflavonoids in human urine, including identification of genistein. Clin. Chem. Acta. 1991, 199: 263-278.

·       Hämäläinen, E.,Fotsis, T., and Adlercreutz, H. A gas chromatographic method for the determination of neutral profiles in urine, including studies on the effect of oxytetracycline administration on these men. Clin. Chim. Acta 1991, 199:  205-220.

·       Schweigerer, L., Scheurich, P., and Fotsis, T. Enhanced MYCN oncogene expression in human neuroblastoma cells results in increased susceptibility to growth inhibition by TNFa. Biochem. Biophys. Res. Commun. 1990, 170: 1301-1307.

·       Fotsis, T., Murphy, C., and Gannon, F. Nucleotide sequence of the bovine insulin-like growth factor I (IGF-I) and its IGF-IA precursor. Nucl. Acids Res. 1990, 18:  676.

·       Adlercreutz, H., Fotsis, T., Höckerstedt, K., Hämäläinen, E., Bannwart, C., Bloigu, S., Valtonen, A., and Ollus, Diet and urinary estrogen profile in premenopausal omnivorous and vegetarian women and in premenopausal women with breast cancer. J. Steroid Biochem. 1989, 34: 527-530.

·       Murphy, C., Fotsis, T., Pantzar, P., Adlercreutz, H., and Martin, F. Analysis of tamoxifen, N-desmethyltamoxifen and 4-hydroxytamoxifen levels in cytosol and KCl-nuclear extracts of breast tumours from tamoxifen treated patients by gas chromatography-mass spectrometry (GC-MS) using selected ion monitoring (SIM). J. Steroid Biochem. 1987, 28:  609-618.

·       Murphy, C., Fotsis, T., Adlercreutz, H., and Martin, F. Analysis of tamoxifen and 4-hydroxytamoxifen levels in immature rat uterine cytoplasm and KCL-nucler extracts by gas chromatography-mass spectrometry (GC-MS) using selected ion monitoring (SIM). J. Steroid Biochem. 1987, 28:  289-299.

·       Fotsis, T. The multicomponent analysis of estrogens in urine by ion exchange chromatography and GC-MS -II. Fractionation and quantitation of the main groups of estrogen conjugates. J. Steroid Biochem. 1987, 28: 215-226.

·       Fotsis, T., and Adlercreutz, H. The multicomponent analysis of estrogens in urine by ion exchange chromatography and GC-MS -I. Quantitation of estrogens after initial hydrolysis ofconjugates. J. Steroid Biochem. 1987, 28: 203-213.

·       Fotsis, T., Shah, H.P., Härkönen, M., and Adlercreutz, H. Fluoroenzymatic cycling assay (FECA) for the determination of catechol estrogen monomethyl ethers in human urine. Neurochemical Research 1987, 12:  507-513.

·       Adlercreutz, H., Höckerstedt, K., Bannwart, C., Bloigu, S.,Hämäläinen, E., Fotsis, T., and Ollus, A. Effect of dietary components, including lignans and phytoestrogens, on enterohepatic circulation and liver metabolism of estrogens and on sex hormone binding globulin (SHBG). J. Steroid Biochem. 1987, 27: 1135-1144.

·       Murphy, C., Fotsis, T., Pantzar, P., Adlercreutz, H., and Martin, F. Analysis of tamoxifen and its metabolites in human plasma by gas chromatography-mass spectrometry (GC-MS) using selected ion monitoring (SIM). J. Steroid Biochem. 1987, 26:  547-555.

·       Adlercreutz, H., Fotsis, T., Bannwart, C., Wähälä, K., Mäkelä, T., Brunow, G., and Hase, T. Determination of urinary lignans and phytoestrogen metabolites, potential antiestrogens and anticarcinogens,in urine of women on various habitual diets. J. Steroid Biochem. 1986, 25: 791-797.

·       Korpela, J.T., Fotsis, T., and Adlercreutz, H. Multicomponent analysis of bile acids in faeces by anion exchange and capillary column gas-liquid chromatography; application in oxytetracycline treated subjects. J. Steroid Biochem. 1986, 25: 277-284.

·       Adlercreutz, H., Musey, P.I., Fotsis, T., Bannwart, C.,Wähälä, K., Mäkelä, T., Brunow, G., and Hase, T. Identification of lignans and phytoestrogens in urine of chimpanzees. Clin. Chim. Acta 1986, 158: 147-154.

·       Adlercreutz, H., Fotsis, T, Bannwart, C., Hämäläinen, E.K.,Bloigu, S., and Ollus, A. Urinary estrogen profile determination in young Finnish vegetarian and omnivorous women. J. Steroid Biochem. 1986, 24: 289-296.

·       Bannwart, C., Adlercreutz, H., Fotsis, T., Wähälä, K., Hase, T., and Brunow, G. Identification of O-desmethylangolesin, a metabolite of daidzein, and of metairesinol, one likely plant precursor of the animal lignan enterolactone, in human urine. Finn. Chem. Lett. 1984, 45:  120-125.

·       Hämäläinen, E.K., Fotsis, T., and Adlercreutz, H. Rapid and reliable separation of 5a-dihydrotestosterone from testosterone on silica gel microcolumns. Clin. Chim. Acta 1984, 139: 173-177.

·       Bannwart, C., Fotsis, T., Heikkinen, R., and Adlercreutz,H. Identification of the isoflavonic phytoestrogen daidzeinin human urine. Clin. Chim. Acta 1984, 136:  165-172.

·       Antila, E., Fotsis, T., Wartiovaara, J., and Adlercreutz, H. Steroid metabolism in human teratocarcinoma cell line PA1. J. Steroid Biochem. 1983, 19: 1583-1590.

·       Heikkinen, R., Fotsis, T., and Adlercreutz, H. Use of ion exchange chromatography in steroid analysis. J. Steroid Biochem. 1983, 19: 175-180.

·       Fotsis, T., and Heikkinen, R. Selective chromatographic fractionation of catechol estrogens on anion exchangers in borate form. J. Steroid Biochem. 1983, 18: 357-363.

·       Adlercreutz, H., Fotsis, T., Heikkinen, R., Dwyer, J.T., Woods, M., Goldin, B.R., and Gorbach, S.L.. Excretion of the lignans, enterolactone and enterodiol, and of equol in omnivorous and vegetarian postmenopausal women and in breast cancer. Lancet 1982, 2: 1295-1299.

·       Fotsis, T., Heikkinen, R., Adlercreutz, H., Axelson, M., and Setchell, K.D.R. Capillary gas chromatographic method for the analysis of lignans in human urine. Clin. Chim. Acta 1982, 121: 361-371.

·       Adlercreutz, H., Fotsis, T., Heikkinen, R., Dwyer, J.T., Goldin, B.R., Gorbach, S.L., Lawson, A.M., and Setchell, K.D.R. Diet and urinary excretion of lignans in female subjects. Medical Biology 1981, 59: 259-261.

·       Heikkinen, R., Fotsis, T., and Adlercreutz, H. Reversed phase C18 cartridge for extraction of estrogens from urine and plasma. Clin. Chem. 1981, 27: 1186-1189.

·       Fotsis, T., Adlercreutz, H., Järvenpää, P., Setchell, K.D.R., Axelson, M., and Sjövall, J. Group separation of steroid conjugates by DEAE-Sephadex anion exchange chromatography. J. Steroid Biochem. 1981, 14: 457-463.

·       Fotsis, T., Järvenpää, P., and Adlercreutz, H.: Identification of 4-hydroxyestriol in pregnancy urine. J. Clin. Endocrinol. Metab. 1980, 51: 148-151.

·       Järvenpää, P., Kosunen, T., Fotsis, T., and Adlercreutz, H. In vitro metabolism of estrogens by isolated intestinal micro-organisms and by human fecal microflora. J. Steroid Biochem. 1980, 13: 345-349.

·       Fotsis, T., Järvenpää, P., and Adlercreutz, H. Purification of urine for quantification of the complete estrogen profile. J. Steroid Biochem. 1980, 12: 503-508.

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