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Carol Murphy

Carol Murphy

Group Leader of FORTH/BR
Email address
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Phone
+30 26510 07815, +30 2811392164
Fax
+30 2651 007077

Research in our lab is focussed on investigating the role of the endocytic pathway in growth factor signaling. We study the role of TGFβ family members (TGFβ, Activin A and BMP4) and VEGF in endothelial cells. We also investigate trafficking and signaling during pluripotency and differentiation using human embryonic stem cells and human induced pluripotent stem cells and are interested in the role of endocytic trafficking during stem cell differentiation.  Finally, we use human embryonic stem cells, human induced pluripotent stem cells and mature primary endothelial cells for translational targets related to tumour angiogenesis and regenerative medicine.

CV in brief | Full CV

Tsolis K, Bagli E, Kanaki K, Zografou S, Carpentier S, Bei E, Christoforidis S, Zervakis M, Murphy C, Fotsis T, Economou A. (2016) Proteome changes during transition from human embryonic to vascular progenitor cells. J Proteome Res. 15:1995-2007.
            
Kyrkou A, Stellas D, Syrrou M, Klinakis A, Fotsis T, Murphy C. (2016) Generation of human induced pluripotent stem cells in defined, feeder-free conditions. Stem Cell Res. 17:458-460.
            
Karali E, Bellou S, Stellas D, Klinakis A, Murphy C, Fotsis T. (2014) VEGF Signals through ATF6 and PERK to promote endothelial cell survival and angiogenesis in the absence of ER stress. Mol Cell. 54:559-72.
            
Kyrkou A, Soufi M, Bahtz R, Ferguson C, Bai M, Parton RG, Hoffmann I, Zerial M, Fotsis T, Murphy C. (2013) RhoD participates in the regulation of cell-cycle progression and centrosome duplication. Oncogene 32:1831-42.

Kostaras E, Sflomos G, Pedersen NM, Stenmark H, Fotsis T, Murphy C. (2013) SARA and RNF11 interact with each other and ESCRT-0 core proteins and regulate degradative EGFR trafficking. Oncogene 32:5220-32.

Publications since 2000

Basagiannis D, Zografou S, Murphy C, Fotsis T, Morbidelli L, Ziche M, Bleck C, Mercer J, Christoforidis S. VEGF induces signalling and angiogenesis by directing VEGFR2 internalisation via macropinocytosis. J Cell Sci 129 (2016) 4091-4104.
https://www.ncbi.nlm.nih.gov/pubmed/27656109

Tsolis K, Bagli E, Kanaki K, Zografou S, Carpentier S, Bei E, Christoforidis S, Zervakis M, Murphy C, Fotsis T, Economou A. Proteome changes during transition from human embryonic to vascular progenitor cells. J Proteome Research 15 (2016) 1995-2007.
https://www.ncbi.nlm.nih.gov/pubmed/27146950

Kyrkou A, Stellas D, Syrrou M, Klinakis A, Fotsis T, Murphy C: Generation of human induced pluripotent stem cells in defined, feeder-free conditions. Stem Cell Research, 17 (2016) 458-460.
https://www.sciencedirect.com/science/article/pii/S1873506116300381

Kouroupis D, Kyrkou A, Triantafyllidi E, Katsimpoulas M, Chalepakis G, Goussia A,  Georgoulis A, Murphy C, Fotsis T: Generation of stem cell-based bioartificial anterior cruciate ligament (ACL) grafts for effective ACL rupture repair. Stem Cell Research 17 (2016) 448-457.
https://www.ncbi.nlm.nih.gov/pubmed/27217303

Karali E, Bellou S, Stellas D, Klinakis A, Murphy C, Fotsis T: ER mediates induction of endothelial cell survival and angiogenesis by VEGF: PLCg via mTORC1 activates ATF6 and PERK. Mol Cell 54 (2014) 559-72.
https://www.ncbi.nlm.nih.gov/pubmed/24746698

Kostaras E, Pedersen NM, Stenmark H, Fotsis T, Murphy C: SARA and RNF11 at the crossroads of EGFR signalling and trafficking. Methods Enzymol 535 (2014) 225-47.
https://www.ncbi.nlm.nih.gov/pubmed/24377927

Bellou S, Pentheroudakis G, Murphy C, Fotsis T: Anti-angiogenesis in cancer therapy: Hercules and Hydra. Cancer Lett. 338 (2013) 291-28.
https://www.ncbi.nlm.nih.gov/pubmed/23707856

Kyrkou A, Soufi M, Bahtz R, Ferguson C, Bai M, Parton RG, Hoffmann I, Zerial M, Fotsis T, Murphy C: RhoD participates in the regulation of cell-cycle progression and centrosome duplication. Oncogene 2013, 32:1831-1842.
https://www.ncbi.nlm.nih.gov/pubmed/22665057

Kyrkou A, Soufi M, Bahtz R, Ferguson C, Bai M, Parton RG, Hoffmann I, Zerial M, Fotsis T, Murphy C: The RhoD to centrosomal duplication. Small GTPases 2013, 4.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3747252/

Kostaras E, Sflomos G, Pedersen NM, Stenmark H, Fotsis T, Murphy C: SARA and RNF11 interact with each other and ESCRT-0 core proteins and regulate degradative EGFR trafficking. Oncogene 32 (2013) 5220-32.
https://www.ncbi.nlm.nih.gov/pubmed/23222715

Bellou S, Karali E, Bagli E, Al-Maharik N, Morbidelli L, Ziche M, Adlercreutz H, Murphy C, Fotsis T: The isoflavone metabolite 6-methoxyequol inhibits angiogenesis and suppresses tumor growth. Mol Cancer 2012, 11:35.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3406996/

Sflomos G, Kostaras E, Panopoulou E, Pappas N, Kyrkou A, Politou AS, Fotsis T, Murphy C: ERBIN is a new SARA-interacting protein: competition between SARA and SMAD2 and SMAD3 for binding to ERBIN. J Cell Sci 2011, 124:3209-3222.
https://www.ncbi.nlm.nih.gov/pubmed/21878490

Bellou S, Hink MA, Bagli E, Panopoulou E, Bastiaens PI, Murphy C, Fotsis T: VEGF autoregulates its proliferative and migratory ERK1/2 and p38 cascades by enhancing the expression of DUSP1 and DUSP5 phosphatases in endothelial cells. Am J Physiol Cell Physiol 2009, 297:C1477-1489.
https://www.ncbi.nlm.nih.gov/pubmed/19741200

Kardassis D, Murphy C, Fotsis T, Moustakas A, Stournaras C: Control of transforming growth factor beta signal transduction by small GTPases. FEBS J 2009, 276:2947-2965.
https://www.ncbi.nlm.nih.gov/pubmed/19490100

Murphy C: Endo-fin-ally a SARA for BMP receptors. J Cell Sci 2007, 120:1153-1155.

Fyhrquist P, Mwasumbi L, Vuorela P, Vuorela H, Hiltunen R, Murphy C, Adlercreutz H: Preliminary antiproliferative effects of some species of Terminalia, Combretum and Pteleopsis collected in Tanzania on some human cancer cell lines. Fitoterapia 2006, 77:358-366.
https://www.ncbi.nlm.nih.gov/pubmed/16797142

Papanikolaou A, Papafotika A, Murphy C, Papamarcaki T, Tsolas O, Drab M, Kurzchalia TV, Kasper M, Christoforidis S: Cholesterol-dependent lipid assemblies regulate the activity of the ecto-nucleotidase CD39. J Biol Chem 2005, 280:26406-26414.
https://www.ncbi.nlm.nih.gov/pubmed/15890655

Panopoulou E, Murphy C, Rasmussen H, Bagli E, Rofstad EK, Fotsis T: Activin A suppresses neuroblastoma xenograft tumor growth via antimitotic and antiangiogenic mechanisms. Cancer Res 2005, 65:1877-1886.
https://www.ncbi.nlm.nih.gov/pubmed/15753386

Bagli E, Stefaniotou M, Morbidelli L, Ziche M, Psillas K, Murphy C, Fotsis T: Luteolin inhibits vascular endothelial growth factor-induced angiogenesis; inhibition of endothelial cell survival and proliferation by targeting phosphatidylinositol 3'-kinase activity. Cancer Res 2004, 64:7936-7946.
https://www.ncbi.nlm.nih.gov/pubmed/15520200

Panopoulou E, Gillooly DJ, Wrana JL, Zerial M, Stenmark H, Murphy C, Fotsis T: Early endosomal regulation of Smad-dependent signalling in endothelial cells. J Biol Chem 2002, 277:18046-18052.
https://www.ncbi.nlm.nih.gov/pubmed/11877415

Karetsou Z, Kretsovali A, Murphy C, Tsolas O, Papamarcaki T: Prothymosin alpha interacts with the CREB-binding protein and potentiates transcription. EMBO Rep 2002, 3:361-366.
https://www.ncbi.nlm.nih.gov/pubmed/11897665

Hatzi E, Murphy C, Zoephel A, Rasmussen H, Morbidelli L, Ahorn H, Kunisada K, Tontsch U, Klenk M, Yamauchi-Takihara K, et al.: N-myc oncogene overexpression down-regulates IL-6; evidence that IL-6 inhibits angiogenesis and suppresses neuroblastoma tumor growth. Oncogene 2002, 21:3552-3561.
https://www.ncbi.nlm.nih.gov/pubmed/12032857

Hatzi E, Murphy C, Zoephel A, Ahorn H, Tontsch U, Bamberger AM, Yamauchi-Takihara K, Schweigerer L, Fotsis T: N-myc oncogene overexpression down-regulates leukemia inhibitory factor in neuroblastoma. Eur J Biochem 2002, 269:3732-3741.
https://www.ncbi.nlm.nih.gov/pubmed/12153570

Murphy C, Saffrich R, Olivo-Marin JC, Giner A, Ansorge W, Fotsis T, Zerial M: Dual function of rhoD in vesicular movement and cell motility. Eur J Cell Biol 2001, 80:391-398.
https://www.ncbi.nlm.nih.gov/pubmed/11484930

Hatzi E, Breit S, Zoephel A, Ashman K, Tontsch U, Ahorn H, Murphy C, Schweigerer L, Fotsis T: MYCN oncogene and angiogenesis: down-regulation of endothelial growth inhibitors in human neuroblastoma cells. Purification, structural, and functional characterization. Adv Exp Med Biol 2000, 476:239-248.
https://www.ncbi.nlm.nih.gov/pubmed/10949669