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Carol Murphy

Carol Murphy

Group Leader of FORTH/BRI
Email address
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Phone
+30 26510 07815, +30 2811392164
Fax
+30 2651 007077
Lab web page

Carol Murphy is a member of BRI-FORTH since 2000. She has a B.Sc (hons) from University College Dublin, Ireland (1982) and a PhD from the same university (1987). She worked as a post-doctoral fellow at the Differentiation Program at the European Molecular Biology Laboratory (EMBL) and also in the Cell Biology Program at the EMBL, Heidelberg, Germany. She then moved to the Laboratory of Biological Chemistry at the University of Ioannina (UOI) Medical School, Greece, where she was funded by the EU as “Experienced Scientist”. Since 2001 she has been working as Researcher B at BRI-FORTH. CM has published 36 papers, has 1,918 citations and several patent applications. Her recent research interests include the intracellular trafficking of receptors and the control of signaling with extension to human stem cells and human induced pluripotent stem cells. She has established and maintains the “Confocal Micro­scopy Unit” at the UOI, more recently adding also super resolution STED microscopy to the facility. She has also success­fully organized workshops at the UOI in “Basic Light Microscopy” in collaboration with other Greek Organizations.

Kostaras E, Sflomos G, Pedersen NM, Stenmark H, Fotsis T, Murphy C. (2013) SARA and RNF11 interact with each other and ESCRT-0 core proteins and regulate degradative EGFR trafficking. Oncogene 32:5220-32.
    
Kyrkou A, Soufi M, Bahtz R, Ferguson C, Bai M, Parton RG, Hoffmann I, Zerial M, Fotsis T, Murphy C. (2013) RhoD participates in the regulation of cell-cycle progression and centrosome duplication. Oncogene 32:1831-42.
    
Sflomos G, Kostaras E, Panopoulou E, Pappas N, Kyrkou A, Politou AS, Fotsis T, Murphy C. (2011) ERBIN is a novel SARA-interacting Protein: Competition between SARA and SMAD2/3 for binding to ERBIN. J Cell Sci. 124:3209-22.
    
Bellou S, Hink MA, Bagli E, Panopoulou E, Bastiaens PI, Murphy C, Fotsis T. (2009) VEGF Auto-regulates its Proliferative and Migratory ERK1/2 and p38 MAPK Cascades by Enhancing the Expression of DUSP1 and DUSP5 Phosphatases in Endothelial Cells. Am J Physiol Cell Physiol. 297:C1477-89.

Publications (after 2000)

Breit, S., Rössler, J., Fotsis, T., and Schweigerer, L. N-myc down-degulates activin A. Biochem. Biophys. Res. Commun. 2000, 274: 405-409.

Breit, S., Ashman, K., Wilting, J., Rössler, J., Hatzi, E., Fotsis, T*., and Schweigerer, L*. The N-myc oncogene in human neuroblastoma cells: down-regulation of an angiogenesis inhibitor identified as activin A. Cancer Res. 2000, 60: 4596-4601. *These authors contributed equally to this work.

Xagorari, A., Papapetropoulos, A., Mavromatis, A., Economou, M., Fotsis, T., and Roussos, C. Luteolin inhibits an endotoxin-stimulated phosphorylation cascade and pro-inflammatory cytokine production in macrophages. J. Pharmacol. Exp. Therap. 2001, 296: 181-187.

Murphy, C., Saffrich, R., Olivo-Marin, J-C., Giner, A., Ansorge, W., Fotsis, T., and Zerial, M. Dual function of rhoD in vesicular movement and cell motility. Eur. J. Cell Biol. 2001, 80: 391-398.

Kotanidou, A., Xagorari, A., Bagli, E., Kitsanta, P., Fotsis, T., Papapetropoulos, A., and Roussos, C.. Luteolin reduces LPS-induced lethal toxicity and expression of pro-inflammatory molecules in mice. Am. J. Resp. Crit. Care Med. 2002, 165: 818-823.

Panopoulou, E., Gillooly, D.J., Jeffrey, J.L., Zerial, M., Stenmark, H., Murphy, C*., and Fotsis, T*. Early Endosomal Regulation of Smad-Dependent Signaling in Endothelial Cells. J. Biol. Chem. 2002, 277: 18046-18052. *These authors contributed equally to this work.

Hatzi, E., Murphy, C., Zoephel, A., Rasmussen, H., Morbidelli, L., Ahorn, A., Kunisada, K., Tontsch, U., Klenk, M., Yamauchi-Takihara, Y., Ziche, M., Rofstad, E.K., Schweigerer, L., and Fotsis, T. N-myc Oncogene Overexpression Down-Regulates IL-6; Evidence that IL-6 Inhibits Angiogenesis and Suppresses Neuroblastoma Tumour Growth. Oncogene 2002, 16: 3552-3561.

Hatzi, E., Murphy, C., Zoephel, A., Ahorn, A., Tontsch, U., Bamberger A-M., Yamauchi-Takihara, Y., Schweigerer, L., and Fotsis, T. N-myc Oncogene Overexpression Down-Regulates Leukemia Inhibitory Factor in Neuroblastoma. Eur. J. Biochem. 2002, 269: 3732-3741.

Zoe Karetsou, Adroniki Kretsovali, Carol Murphy, Orestes Tsolas and Thomais Papamarcaki. Prothymosin a interacts with the CREB-binding protein (CBP) and potentiates transcription. EMBO reports 2002, 3: 361-366.

Roussou I, Lambropoulos I, Pagoulatos GN, Fotsis T, Roussis IG. Decrease of heat shock protein levels and cell populations by wine phenolic extracts. J Agric Food Chem. 2004, 52(4): 1017-24.

Bagli E, Stefaniotou M, Morbidelli L, Ziche M, Psillas K, Murphy C, Fotsis T. Luteolin inhibits vascular endothelial growth factor-induced angiogenesis; inhibition of endothelial cell survival and proliferation by targeting phosphatidylinositol 3'-kinase activity. Cancer Res. 2004, 64(21): 7936-46.

Adlercreutz H, Kiuru P, Rasku S, Wahala K, Fotsis T. An isotope dilution gas chromatographic-mass spectrometric method for the simultaneous assay of estrogens and phytoestrogens in urine. J Steroid Biochem Mol Biol. 2004, 92(5): 399-411.

Panopoulou E, Murphy C, Rasmussen H, Bagli E, Rofstad EK, Fotsis T. Activin A suppresses neuroblastoma xenograft tumor growth via antimitotic and antiangiogenic mechanisms. Cancer Res. 2005, 65(5): 1877-86.

Karavasilis V, Malamou-Mitsi V, Briasoulis E, Tsanou E, Kitsou E, Kalofonos H, Fountzilas G, Fotsis T, Pavlidis N. Angiogenesis in cancer of unknown primary: clinicopathological study of CD34, VEGF and TSP-1. BMC Cancer. 2005, 5(1): 25.

Karavasilis V, Malamou-Mitsi V, Briasoulis E, Tsanou E, Kitsou E, Kalofonos H, Fountzilas G, Fotsis T, Pavlidis N. Matrix metalloproteinases in carcinoma of unknown primary. Cancer. 2005, 104(10):2282-7.

Murphy, C. Endo-fin-ally a SARA for BMP receptors. J Cell Sci. 2007, 120: 1153-1155.

Goulas V, Exarchou V, Troganis AN, Psomiadou E, Fotsis T, Briasoulis E, Gerothanassis IP. Phytochemicals in olive-leaf extracts and their antiproliferative activity against cancer and endothelial cells. Mol Nutr Food Res. 2009, 53: 600-608.

Kardassis D, Murphy C, Fotsis T, Moustakas A and Stournaras C. Control of TGFβ signal transduction by small GTPases. FEBS J 2009, 276: 22947-65.

Moumtzi SS, Roberts LM, Joyce T, Euagelidou M, Probert L, Frillingos S, Fotsis T, and Pintzas A. Gene expression profile associated with oncogenic RAS-induced senenscence, cell death and transforming properties in human cells. Cancer Invest 2009 (in press)

Bellou S, Mark A Hink, AM, Bagli E, Panopoulou E, Bastiaens PIH, Murphy C, Fotsis T. VEGF Auto-regulates its Proliferative and Migratory ERK1/2 and p38 MAPK Cascades by Enhancing the Expression of DUSP1 and DUSP5 Phosphatases in Endothelial Cells. Am J Physiol Cell Physiol 2009, 297: C1477-89.

Moumtzi SS, Roberts LM, Joyce T, Euagelidou M, Probert L, Frillingos S, Fotsis T, and Pintzas A. Gene expression profile associated with oncogenic RAS-induced senenscence, cell death and transforming properties in human cells. Cancer Invest 2010, 28: 563-587.

Sflomos G, Kostaras E, Panopoulou E, Pappas N, Kyrkou A, Politou AS, Fotsis T, Murphy C: ERBIN is a new SARA-interacting protein: competition between SARA and SMAD2 and SMAD3 for binding to ERBIN. J Cell Sci 2011, 124:3209-3222.

Kostaras E, Sflomos G, Pedersen NM, Stenmark H, Fotsis T* and Murphy C*.: SARA and RNF11 interact with each other and ESCRT-0 core proteins and regulate degradative EGFR trafficking. Oncogene 2013. *Equal contribution to this work.

Kyrkou A, Soufi M, Bahtz R, Ferguson C, Bai M, Parton RG, Hoffmann I, Zerial M, Fotsis T, Murphy C: The RhoD to centrosomal duplication. Small GTPases 2013, 4.

Kyrkou A, Soufi M, Bahtz R, Ferguson C, Bai M, Parton RG, Hoffmann I, Zerial M, Fotsis T, Murphy C: RhoD participates in the regulation of cell-cycle progression and centrosome duplication. Oncogene 2013, 32:1831-1842.

Kostaras E, Pedersen NM, Stenmark H, Fotsis T, Murphy C: SARA and RNF11 at the crossroads of EGFR signalling and trafficking. Methods Enzymol 2013 in press.

Bellou S, Pentheroudakis G, Murphy C, Fotsis T., Anti-angiogenesis in cancer therapy: Hercules and hydra., Cancer Lett. 2013, 338(2):219-228.

Kostaras E., Sflomos G, Pedersen NM, Stenmark H, Fotsis T and Murphy C. “SARA and RNF11 Interact with Each Other and ESCRT-0 Core Proteins and Regulate Degradative EGFR Trafficking”. Oncogene 2013, 32 (44): 5220-5232.

Kostaras, E; Pedersen, NM; Stenmark, H; Fotsis, T; Murphy, C, SARA and RNF11 at the Crossroads of EGFR Signaling and Trafficking, ENDOSOME SIGNALING, PT B, Book Series: Methods in Enzymology 2014, 535: 225-247.

Karali, E; Bellou, S; Stellas, D; Klinakis, A; Murphy, C; Fotsis, T, VEGF Signals through ATF6 and PERK to Promote Endothelial Cell Survival and Angiogenesis in the Absence of ER Stress, MOLECULAR CELL 2014, 54(4): 559-572.

Yang J, AlTahan AM, Hu D, Wang Y, Cheng PH, Morton CL, Qu C, Nathwani AC, Shohet JM, Fotsis T, Koster J, Versteeg R, Okada H, Harris AL, Davidoff AM. The role of histone demethylase KDM4B in Myc signaling in neuroblastoma. Journal of National Cancer Institute2015, 107(6):djv080.

Sanchez-Duffhues G, Fotsis T, ten Dijke P. Signal Transduction: Gain of Activin Turns Muscle into Bone. Curr Biol. 2015, 25(23):R1136-8.

Tsolis KC, Bagli E, Kanaki K, Zografou S, Carpentier S, Bei ES, Christoforidis S, Zervakis M, Murphy C, Fotsis T, Economou A. Proteome Changes during Transition from Human Embryonic to Vascular Progenitor Cells. J Proteome Res. 2016 Jun 3;15(6):1995-2007.

Mantzaris MD, Bellou S, Skiada V, Kitsati N, Fotsis T, Galaris D. Intracellular labile iron determines H2O2-induced apoptotic signaling via sustained activation of ASK1/JNK-p38 axis. Free Radic Biol Med. 2016, 97:454-65.

Kouroupis D, Kyrkou A, Triantafyllidi E, Katsimpoulas M, Chalepakis G, Goussia A, Georgoulis A, Murphy C, Fotsis T. Generation of stem cell-based bioartificial anterior cruciate ligament (ACL) grafts for effective ACL rupture repair. Stem Cell Res. 2016, 17(2):448-457.

Basagiannis D, Zografou S, Murphy C, Fotsis T, Morbidelli L, Ziche M, Bleck C, Mercer J, Christoforidis S. VEGF induces signalling and angiogenesis by directing VEGFR2 internalisation through macropinocytosis. J Cell Sci. 2016, 129(21):4091-4104.

Kyrkou A, Stellas D, Syrrou M, Klinakis A, Fotsis T, Murphy C. Generation of human induced pluripotent stem cells in defined, feeder-free conditions. Stem Cell Res. 2016,17(2):458-460.

Vlaikou AM, Kouroupis D, Sgourou A, Markopoulos GS, Bagli E, Markou M, Papadopoulou Z, Fotsis T, Nakos G, Lekka ME, Syrrou M. Mechanical stress affects methylation pattern of GNAS isoforms and osteogenic differentiation of hAT-MSCs. Biochim Biophys Acta. 2017, 1864(8):1371-1381.

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