Proteomics deals with large scale analysis of proteins and their interactions in relation to biological functions. Following technical and scientific breakthroughs, proteomics is now becoming more integrated with genetic information and clinical data. The Proteins@Work proteomics facility will provide high level proteomics technology, equipment and expertise to the Dutch biological and biomedical communities. De facility will be essential for Life Sciences and Health research (e.g. prevention and diagnosis of cancer) and will contribute to the innovative climate in the Netherlands.
Provides European Union funded access to an infrastructure of state-of-the-art proteomics technology to the biological and biomedical research community in Europe.
The EuTRACC consortium proposes to determine the regulation of the genome by mapping the regulatory pathways and networks of transcription factors that control cellular functions. EuTRACC will be part of and work in close collaboration with the International Regulome Consortium (IRC), a worldwide network that will address the regulation of genome function at a higher level by mapping the genetic regulatory nodes and networks that control the activity of embryonic stem cells and the process of differentiation to specific cell types. The project will focus on mapping the genetic circuitry that controls the formation of neural tissues and the blood system. The project will utilize genetics, proteomics and genomics tools in the mouse, zebrafish and Xenopus model organisms.
- EuTracc (European Transcriptome, Regulome & Cellular Commitment Consortium)
The EuTRACC consortium will use genomics, proteomics and in vivo phenotyping to describe the network of TFs that regulates embryonic stem cell differentiation into neuronal and haematopoietic lineages. Computational analyses of these data will allow major progress towards understanding the mechanisms of transcriptional control of lineage commitment, ultimately leading to the modelling of these processes.
HEROIC Π High-throughput Epigenetic Regulatory Organisation In Chromatin Π is an Integrated Project striving to further epigenetic research supported by a 12 MEuro grant from the EU-FP6
The largest EU-funded project in the field of proteomics with the mission to develop novel technologies for proteomics research.
Targets the integration of a full proteomics analysis chain, from blood sample to the diagnosis information, combining bio-, nano, and information-related technologies. It includes an innovative patented lab-on-chip developed at CEA. The clinical application is early pancreatic cancer diagnosis.
A Research Network to develop new optical technologies to monitor protein interactions and post-translational modifications in cells, and to advance understanding of the function of protein networks in situ. Significant advances in understanding normal cell function and in developing successful strategies for therapeutic intervention in disease will increasingly depend on the ability to study protein complexes and networks in the cellular environment. Such complexes may be localised in cellular compartments or at the cell membrane, they may be dynamic, they may depend on specific post-translational modifications, and they may require interactions with other macromolecules. Optical techniques can, in principle, provide all these types of information from intact cells and tissues without disrupting the normal protein or cell function. In practice the realization of this potential will depend on the development and application of new technologies in molecular biology, chemical biology, biophotonics, nano-optics, instrumentation, bioinformatics, biochemical proteomics, and network modelling. The Optical Proteomics Interdisciplinary Research Network brings together research groups from these different disciplines to develop these technologies and apply them to real clinical problems
Platform technology development programme intended to provide novel tools and techniques for protein analysis, and in particular protein analysis at the single cell level. The intention is that these platforms be capable of providing complimentary capability to those powerful proteomics tools already available to the research community. The main drivers are focused on providing enhanced capability with respect to the following: Single Cell Sensitivity, Absolute Quantification, Top Down Proteomics, Spatio-Temporal Proteomics, Analysis of complexation and post translational modification
In pursuing these aims we are focused on three technology streams: Label-Free Optical Proteomics, Single Cell Sensitivity Protein Chips, Smart Droplet Microtools for Proteomics
Eukaryotic unicellular organism biology Π systems biology of the control of cell growth and proliferation. Objective: of a quantitative understanding of fundamental characteristics of eukaryotic unicellular organism biology: how cell growth and proliferation are controlled and coordinated by extracellular and intrinsic stimuli.
Yeast Systems Biology Network (YSBN)-consortium of researchers promoting Systems Biology with the yeast Saccharomyces cerevisiae as a model system.