ΜΒΒ 105-ΒΙΟ 505 Bioinformatics 20 hours

ΑVAILABLE TOOLS FOR BIOINFORMATICS, 2 h

1. Analyzing DNA sequences - applications of machine learning in Biology, 3 h

a. DNA pattern recognition - identifying cis-regulatory elements
b. Gene finding in mammalian genomes

2. Systems Biology, 3 h

a. Modeling Gene Regulatory Networks
b. Data integration in Systems Biology

3. Principles and Methods of Sequence Analysis, 2 h

a. Methods for searching similar sequences
b. Principles and bioinformatics-applications of artificial neural networks
c. Principles and bioinformatics-applications of genetic algorithms

4. Information Sources for Genomics, 3 h

a. General purpose sequence Databases
b. Protein sequence motif and domain databases

5. Genome Annotation and Analysis, 3 h

a. Genome Projects
b. Tools and Methods
c. Genome context analysis

6. Searching sequence similarities, 4 h

a. SRS-entrez
b. Blast
c. Clustal-Principle of Phylogenetics

7. Comparative Genomics and Evolution, 4 h

a. The tree of Life before and after the Genome
b. Evolutionary issues
c. Protein-protein interaction and functional network
d. Text mining

8. Post-Genomics - Proteomics, 2 h

a. Microarray data: analysis methods