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R-loops trigger the release of cytoplasmic ssDNAs leading to chronic inflammation upon DNA damage

R-loops trigger the release of cytoplasmic ssDNAs leading to chronic inflammation upon DNA damage

IMBB Researchers revealed that DNA damage triggers the release of cytoplasmic ssDNAs leading to chronic inflammation in mice. The team has developed a therapeutic strategy to deliver recombinant nucleases in vivo and remove cytoplasmic ssDNAs, alleviating inflammation.

[Pubmed] [Press Release]

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