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IL-33-decorated neutrophil extracellular traps promote IFNα production in SLE

IL-33-decorated neutrophil extracellular traps promote IFNα production in SLE

Work by the Laboratory of Rheumatology, Autoimmunity and Inflammation demonstrates neutrophil extracellular traps (NETs) decorated with bioactive IL-33 in the blood and inflamed tissues of patients with Systemic Lupus Erythematosus (SLE). IL-33-decorated NETs induce IFNα synthesis by plasmatocytoid dendritic cells through the ST2L receptor.

[JCI Insight]

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