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Cancer associated fibroblasts form immune synapses with T regulatory cells, promoting tumor expansion

Researchers found that cancer associated fibroblasts (CAFs) directly interact with T regulatory cells (Tregs), hampering Treg activation and proliferation, in a process affected by CAF autophagy. Their results suggest that disrupting CAF-Treg synapses could be a promising therapeutic strategy to inhibit tumor progression.

[PubMed]