- Published in Research News
Cancer associated fibroblasts form immune synapses with T regulatory cells, promoting tumor expansion
Researchers found that cancer associated fibroblasts (CAFs) directly interact with T regulatory cells (Tregs), hampering Treg activation and proliferation, in a process affected by CAF autophagy. Their results suggest that disrupting CAF-Treg synapses could be a promising therapeutic strategy to inhibit tumor progression.
[PubMed]