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Christos Tsatsanis

Christos Tsatsanis

Professor, Univ. of Crete
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+30-2810-394833
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Our research aims to delineate the molecular mechanisms regulating inflammation and inflammatory diseases and identify biomarkers and therapeutic targets. In this context the lab analyzes mechanisms regulating activation and inactivation of macrophages at the level of signal transduction, cell metabolism and epigenetics. How metabolic changes at the level of organism (obesity, insulin resistance, microbiome) or at the cellular level (expression of signaling regulators or epigenetic modulators) affect innate immune training and alter responses to pathogens or other inflammatory triggers is investigated. The impact of nutrition on shaping innate immune responses and trained immunity is studied. The lab also focuses in the identification of circulating non-coding RNAs as biomarkers of inflammation-related disorders.

Ieronymaki E, Theodorakis EM, Lyroni K, Vergadi E, Lagoudaki E, Al-Qahtani A, Aznaourova M, Neofotistou-Themeli E, Eliopoulos AG, Vaporidi K, Tsatsanis C. (2019) Insulin Resistance in Macrophages Alters Their Metabolism and Promotes an M2-Like Phenotype. J Immunol. 202:1786-1797.

Lyroni K, Patsalos A, Daskalaki MG, Doxaki C, Soennichsen B, Helms M, Liapis I, Zacharioudaki V, Kampranis SC, Tsatsanis C. (2017) Epigenetic and Transcriptional Regulation of IRAK-M Expression in Macrophages. J Immunol. 198:1297-1307.

Vergadi E, Vaporidi K, Theodorakis EE, Doxaki C, Lagoudaki E, Ieronymaki E, Alexaki VI, Helms M, Kondili E, Soennichsen B, Stathopoulos EN, Margioris AN, Georgopoulos D, Tsatsanis C. (2014) Akt2 deficiency protects from acute lung injury via alternative macrophage activation and miR-146a induction in mice. J. Immunol. 192:394-406.

Arranz A, Doxaki C, Vergadi E, Martinez de la Torre Y, Vaporidi K, Lagoudaki ED, Ieronymaki E, Androulidaki A, Venihaki M, Margioris AN, Stathopoulos EN, Tsichlis PN, Tsatsanis C. (2012) Akt1 and Akt2 protein kinases differentially contribute to macrophage polarization. Proc Natl Acad Sci U S A. 109:9517-22.

Androulidaki A, Iliopoulos D, Arranz A, Doxaki C, Schworer S, Zacharioudaki V, Margioris AN, Tsichlis PN, Tsatsanis C. (2009) The kinase Akt1 controls macrophage response to lipopolysaccharide by regulating microRNAs. Immunity 31:220-31.

Canonical PI3Kγ signaling in myeloid cells restricts Trypanosoma cruzi infection and dampens chagasic myocarditis. Silva MC, Davoli-Ferreira M, Medina TS, Sesti-Costa R, Silva GK, Lopes CD, Cardozo LE, Gava FN, Lyroni K, Dias FC, Frade AF, Baron M, Nakaya HI, Figueiredo F, Alves-Filho JC, Cunha FQ, Tsatsanis C, Chevillard C, Cunha-Neto E, Hirsch E, Silva JS, Cunha TM. Nat Commun. 2018 Apr 17;9(1):1513. doi: 10.1038/s41467-018-03986-3.

Alterations in Serum MicroRNA Profile During Hemodialysis - Potential Biological Implications. Trzybulska D, Eckersten D, Giwercman A, Christensson A, Tsatsanis C. Cell Physiol Biochem. 2018;46(2):793-801. doi: 10.1159/000488737. Epub 2018 Mar 29.

Histone methylation and acetylation in macrophages as a mechanism for regulation of inflammatory responses. Daskalaki MG, Tsatsanis C, Kampranis SC. J Cell Physiol. 2018 Sep;233(9):6495-6507. doi: 10.1002/jcp.26497. Epub 2018 Mar 25. Review.

Adiponectin levels may help assess the clinical repercussions of obesity irrespective of body mass index. Dermitzaki E, Avgoustinaki PD, Spyridaki EC, Simos P, Malliaraki N, Venihaki M, Tsatsanis C, Margioris AN. Hormones (Athens). 2017 Jul;16(3):271-281. doi: 10.14310/horm.2002.1746.

Pharmacokinetics and efficacy of intraocular flurbiprofen. Blazaki S, Tsika C, Tzatzarakis M, Naoumidi E, Tsatsakis A, Tsatsanis C, Tsilimbaris MK. Graefes Arch Clin Exp Ophthalmol. 2017 Dec;255(12):2375-2380. doi: 10.1007/s00417-017-3812-9. Epub 2017 Sep 29.

DHEA inhibits acute microglia-mediated inflammation through activation of the TrkA-Akt1/2-CREB-Jmjd3 pathway. Alexaki VI, Fodelianaki G, Neuwirth A, Mund C, Kourgiantaki A, Ieronimaki E, Lyroni K, Troullinaki M, Fujii C, Kanczkowski W, Ziogas A, Peitzsch M, Grossklaus S, Sönnichsen B, Gravanis A, Bornstein SR, Charalampopoulos I, Tsatsanis C, Chavakis T. Mol Psychiatry. 2018 Jun;23(6):1410-1420. doi: 10.1038/mp.2017.167. Epub 2017 Sep 12.

Serum microRNAs in male subfertility-biomarkers and a potential pathogenetic link to metabolic syndrome. Trzybulska D, Bobjer J, Giwercman A, Tsatsanis C.
J Assist Reprod Genet. 2017 Oct;34(10):1277-1282. doi: 10.1007/s10815-017-0989-0. Epub 2017 Jun 29.

MicroRNA-155 and Anti-Müllerian Hormone: New Potential Markers of Subfertility in Men with Chronic Kidney Disease. Eckersten D, Tsatsanis C, Giwercman A, Bruun L, Pihlsgård M, Christensson A. Nephron Extra. 2017 Apr 7;7(1):33-41. doi: 10.1159/000458711. eCollection 2017 Jan-Apr.

Middle east respiratory syndrome corona virus spike glycoprotein suppresses macrophage responses via DPP4-mediated induction of IRAK-M and PPARγ. Al-Qahtani AA, Lyroni K, Aznaourova M, Tseliou M, Al-Anazi MR, Al-Ahdal MN, Alkahtani S, Sourvinos G, Tsatsanis C. Oncotarget. 2017 Feb 7;8(6):9053-9066. doi: 10.18632/oncotarget.14754.

Akt Signaling Pathway in Macrophage Activation and M1/M2 Polarization. Vergadi E, Ieronymaki E, Lyroni K, Vaporidi K, Tsatsanis C. J Immunol. 2017 Feb 1;198(3):1006-1014. doi: 10.4049/jimmunol.1601515. Review.

The Multi-faceted Profile of Corticotropin-releasing Factor (CRF) Family of Neuropeptides and of their Receptors on the Paracrine/Local Regulation of the Inflammatory Response. Dermitzaki E, Venihaki M, Tsatsanis C, Gravanis A, Avgoustinaki PD, Liapakis G, Margioris AN. Curr Mol Pharmacol. 2018;11(1):39-50. doi: 10.2174/1874467210666170109164430.

Epigenetic and Transcriptional Regulation of IRAK-M Expression in Macrophages. Lyroni K, Patsalos A, Daskalaki MG, Doxaki C, Soennichsen B, Helms M, Liapis I, Zacharioudaki V, Kampranis SC, Tsatsanis C. J Immunol. 2017 Feb 1;198(3):1297-1307. doi: 10.4049/jimmunol.1600009. Epub 2016 Dec 23.

Editorial. Giwercman A, Goulis DG, Huhtaniemi I, Tsatsanis C. Hormones (Athens). 2015 Oct-Dec;14(4):467. No abstract available.

The impact of adipose tissue-derived factors on the hypothalamic-pituitary-gonadal (HPG) axis. Tsatsanis C, Dermitzaki E, Avgoustinaki P, Malliaraki N, Mytaras V, Margioris AN. Hormones (Athens). 2015 Oct-Dec;14(4):549-62. doi: 10.14310/horm.2002.1649. Review.

Coordinated Regulation of miR-155 and miR-146a Genes during Induction of Endotoxin Tolerance in Macrophages. Doxaki C, Kampranis SC, Eliopoulos AG, Spilianakis C, Tsatsanis C. J Immunol. 2015 Dec 15;195(12):5750-61. doi: 10.4049/jimmunol.1500615. Epub 2015 Nov 4.

Genetic and pharmacologic inhibition of Tpl2 kinase is protective in a mouse model of ventilator-induced lung injury. Kaniaris E, Vaporidi K, Vergadi E, Theodorakis EE, Kondili E, Lagoudaki E, Tsatsanis C, Georgopoulos D. Intensive Care Med Exp. 2014 Dec;2(1):15. doi: 10.1186/2197-425X-2-15. Epub 2014 May 9.

ACTH Action on the Adrenals. Margioris AN, Tsatsanis C. In: De Groot LJ, Chrousos G, Dungan K, Feingold KR, Grossman A, Hershman JM, Koch C, Korbonits M, McLachlan R, New M, Purnell J, Rebar R, Singer F, Vinik A, editors. Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc.; 2000-2016 Oct 26.

Serum miR-155 as a potential biomarker of male fertility. Tsatsanis C, Bobjer J, Rastkhani H, Dermitzaki E, Katrinaki M, Margioris AN, Giwercman YL, Giwercman A. Hum Reprod. 2015 Apr;30(4):853-60. doi: 10.1093/humrep/dev031. Epub 2015 Mar 3.

Corticotrophin-Releasing Factor (CRF) and the urocortins are potent regulators of the inflammatory phenotype of human and mouse white adipocytes and the differentiation of mouse 3T3L1 pre-adipocytes. Dermitzaki E, Liapakis G, Androulidaki A, Venihaki M, Melissas J, Tsatsanis C, Margioris AN. PLoS One. 2014 May 16;9(5):e97060. doi: 10.1371/journal.pone.0097060. eCollection 2014.

Effect of different seasonal strength training protocols on circulating androgen levels and performance parameters in professional soccer players. Koundourakis NE, Androulakis N, Spyridaki EC, Castanas E, Malliaraki N, Tsatsanis C, Margioris AN. Hormones (Athens). 2014 Jan-Mar;13(1):104-18.

The gut microbiota in mouse models of inflammatory bowel disease. Gkouskou KK, Deligianni C, Tsatsanis C, Eliopoulos AG. Front Cell Infect Microbiol. 2014 Feb 28;4:28. doi: 10.3389/fcimb.2014.00028. eCollection 2014. Review.

Discrepancy between exercise performance, body composition, and sex steroid response after a six-week detraining period in professional soccer players. Koundourakis NE, Androulakis NE, Malliaraki N, Tsatsanis C, Venihaki M, Margioris AN. PLoS One. 2014 Feb 19;9(2):e87803. doi: 10.1371/journal.pone.0087803. eCollection 2014.

Akt2 deficiency protects from acute lung injury via alternative macrophage activation and miR-146a induction in mice. Vergadi E, Vaporidi K, Theodorakis EE, Doxaki C, Lagoudaki E, Ieronymaki E, Alexaki VI, Helms M, Kondili E, Soennichsen B, Stathopoulos EN, Margioris AN, Georgopoulos D, Tsatsanis C. J Immunol. 2014 Jan 1;192(1):394-406. doi: 10.4049/jimmunol.1300959. Epub 2013 Nov 25.

Helical optical projection tomography. Arranz A, Dong D, Zhu S, Rudin M, Tsatsanis C, Tian J, Ripoll J. Opt Express. 2013 Nov 4;21(22):25912-25. doi: 10.1364/OE.21.025912.

DNA damage triggers a chronic autoinflammatory response, leading to fat depletion in NER progeria. Karakasilioti I, Kamileri I, Chatzinikolaou G, Kosteas T, Vergadi E, Robinson AR, Tsamardinos I, Rozgaja TA, Siakouli S, Tsatsanis C, Niedernhofer LJ, Garinis GA. Cell Metab. 2013 Sep 3;18(3):403-15. doi: 10.1016/j.cmet.2013.08.011.

Negative association between testosterone concentration and inflammatory markers in young men: a nested cross-sectional study. Bobjer J, Katrinaki M, Tsatsanis C, Lundberg Giwercman Y, Giwercman A. PLoS One. 2013 Apr 18;8(4):e61466. doi: 10.1371/journal.pone.0061466. Print 2013.

PPAR agonist-induced reduction of Mcp1 in atherosclerotic plaques of obese, insulin-resistant mice depends on adiponectin-induced Irak3 expression. Hulsmans M, Geeraert B, Arnould T, Tsatsanis C, Holvoet P. PLoS One. 2013 Apr 19;8(4):e62253. doi: 10.1371/journal.pone.0062253. Print 2013.

Predictive and prognostic value of LPS-stimulated cytokine secretion in metastatic non-small cell lung cancer. Vlachostergios PJ, Gioulbasanis I, Ghosh S, Tsatsanis C, Papatsibas G, Xyrafas A, Hatzidaki E, Vasiliou C, Kamposioras K, Agelaki S, Margioris AN, Nasi D, Georgoulias V, Papandreou CN. Clin Transl Oncol. 2013 Nov;15(11):903-9. doi: 10.1007/s12094-013-1021-5. Epub 2013 Mar 5.

Impaired clearance of apoptotic cells leads to HMGB1 release in the bone marrow of patients with myelodysplastic syndromes and induces TLR4-mediated cytokine production. Velegraki M, Papakonstanti E, Mavroudi I, Psyllaki M, Tsatsanis C, Oulas A, Iliopoulos I, Katonis P, Papadaki HA. Haematologica. 2013 Aug;98(8):1206-15. doi: 10.3324/haematol.2012.064642. Epub 2013 Feb 12.

Treatment of experimental murine colitis with CD40 antisense oligonucleotides delivered in amphoteric liposomes. Arranz A, Reinsch C, Papadakis KA, Dieckmann A, Rauchhaus U, Androulidaki A, Zacharioudaki V, Margioris AN, Tsatsanis C, Panzner S. J Control Release. 2013 Feb 10;165(3):163-72. doi: 10.1016/j.jconrel.2012.11.008. Epub 2012 Nov 21.

Aberrant expression of corticotropin-releasing hormone in pre-eclampsia induces expression of FasL in maternal macrophages and extravillous trophoblast apoptosis. Petsas G, Jeschke U, Richter DU, Minas V, Hammer A, Kalantaridou S, Toth B, Tsatsanis C, Friese K, Makrigiannakis A. Mol Hum Reprod. 2012 Nov;18(11):535-45. doi: 10.1093/molehr/gas027. Epub 2012 Jul 4.

Akt1 and Akt2 protein kinases differentially contribute to macrophage polarization. Arranz A, Doxaki C, Vergadi E, Martinez de la Torre Y, Vaporidi K, Lagoudaki ED, Ieronymaki E, Androulidaki A, Venihaki M, Margioris AN, Stathopoulos EN, Tsichlis PN, Tsatsanis C. Proc Natl Acad Sci U S A. 2012 Jun 12;109(24):9517-22. doi: 10.1073/pnas.1119038109. Epub 2012 May 30.

Tpl2 ablation promotes intestinal inflammation and tumorigenesis in Apcmin mice by inhibiting IL-10 secretion and regulatory T-cell generation. Serebrennikova OB, Tsatsanis C, Mao C, Gounaris E, Ren W, Siracusa LD, Eliopoulos AG, Khazaie K, Tsichlis PN. Proc Natl Acad Sci U S A. 2012 May 1;109(18):E1082-91. doi: 10.1073/pnas.1115098109. Epub 2012 Mar 26.

Interleukin-1 receptor-associated kinase-3 is a key inhibitor of inflammation in obesity and metabolic syndrome. Hulsmans M, Geeraert B, De Keyzer D, Mertens A, Lannoo M, Vanaudenaerde B, Hoylaerts M, Benhabilès N, Tsatsanis C, Mathieu C, Holvoet P. PLoS One. 2012;7(1):e30414. doi: 10.1371/journal.pone.0030414. Epub 2012 Jan 17.

Association between regulator of G protein signaling 9-2 and body weight. Waugh JL, Celver J, Sharma M, Dufresne RL, Terzi D, Risch SC, Fairbrother WG, Neve RL, Kane JP, Malloy MJ, Pullinger CR, Gu HF, Tsatsanis C, Hamilton SP, Gold SJ, Zachariou V, Kovoor A. PLoS One. 2011;6(11):e27984. doi: 10.1371/journal.pone.0027984. Epub 2011 Nov 23.

Increased levels of the high mobility group box 1 protein sustain the inflammatory bone marrow microenvironment in patients with chronic idiopathic neutropenia via activation of toll-like receptor 4. Velegraki M, Koutala H, Tsatsanis C, Papadaki HA. J Clin Immunol. 2012 Apr;32(2):312-22. doi: 10.1007/s10875-011-9620-9. Epub 2011 Nov 30.

Baseline plasma levels of interleukin-8 in stage IV non-small-cell lung cancer patients: relationship with nutritional status and prognosis. Gioulbasanis I, Patrikidou A, Kitikidou K, Papadimitriou K, Vlachostergios PJ, Tsatsanis C, Margioris AN, Papandreou CN, Mavroudis D, Georgoulias V. Nutr Cancer. 2012;64(1):41-7. doi: 10.1080/01635581.2012.630157. Epub 2011 Nov 18.

The calcineurin-nuclear factor of activated T cells signaling pathway mediates the effect of corticotropin releasing factor and urocortins on catecholamine synthesis. Dermitzaki E, Tsatsanis C, Gravanis A, Margioris AN. J Cell Physiol. 2012 May;227(5):1861-72. doi: 10.1002/jcp.22914.

Mapping the CRF-urocortins system in human osteoarthritic and rheumatoid synovial fibroblasts: effect of vasoactive intestinal peptide. Pérez-García S, Juarranz Y, Carrión M, Gutiérrez-Cañas I, Margioris A, Pablos JL, Tsatsanis C, Gomariz RP. J Cell Physiol. 2011 Dec;226(12):3261-9. doi: 10.1002/jcp.22687.

Leishmania infantum and Toxoplasma gondii: Mixed infection of macrophages in vitro and in vivo. Christodoulou V, Messaritakis I, Svirinaki E, Tsatsanis C, Antoniou M. Exp Parasitol. 2011 Jul;128(3):279-84. doi: 10.1016/j.exppara.2011.02.022. Epub 2011 Feb 24.

Correlation between serum 25-hydroxyvitamin D levels and quadriceps muscle strength in elderly cretans. Dretakis OE, Tsatsanis C, Fyrgadis A, Drakopoulos CG, Steriopoulos K, Margioris AN. J Int Med Res. 2010 Sep-Oct;38(5):1824-34.

Intravital spectral imaging as a tool for accurate measurement of vascularization in mice. Arranz A, Androulidaki A, Mol B, Tsentelierou E, Stathopoulos EN, Tsatsanis C, Ripoll J. J Angiogenes Res. 2010 Oct 25;2:22. doi: 10.1186/2040-2384-2-22.

The impact of stress on tumor growth: peripheral CRF mediates tumor-promoting effects of stress. Arranz A, Venihaki M, Mol B, Androulidaki A, Dermitzaki E, Rassouli O, Ripoll J, Stathopoulos EN, Gomariz RP, Margioris AN, Tsatsanis C. Mol Cancer. 2010 Sep 27;9:261. doi: 10.1186/1476-4598-9-261.

Association between H1N1 infection severity and obesity-adiponectin as a potential etiologic factor. Tsatsanis C, Margioris AN, Kontoyiannis DP. J Infect Dis. 2010 Aug 15;202(3):459-60. doi: 10.1086/653842. No abstract available.

Feedback inhibition of human scavenger receptor class B type I gene expression by glucocorticoid in adrenal and ovarian cells. Mavridou S, Venihaki M, Rassouli O, Tsatsanis C, Kardassis D. Endocrinology. 2010 Jul;151(7):3214-24. doi: 10.1210/en.2009-1302. Epub 2010 May 12.

Elderly patients with trochanteric hip fracture have lower serum Vitamin D levels compared to patients with cervical hip fracture. Dretakis OE, Margioris AN, Tsatsanis C, Dretakis KE, Malliaraki N, Steriopoulos K. Arch Gerontol Geriatr. 2011 Jan-Feb;52(1):e15-8. doi: 10.1016/j.archger.2010.03.023. Epub 2010 Apr 27.

Ablation of tumor progression locus 2 promotes a type 2 Th cell response in Ovalbumin-immunized mice. Watford WT, Wang CC, Tsatsanis C, Mielke LA, Eliopoulos AG, Daskalakis C, Charles N, Odom S, Rivera J, O'Shea J, Tsichlis PN. J Immunol. 2010 Jan 1;184(1):105-13. doi: 10.4049/jimmunol.0803730. Epub 2009 Dec 2.

The metabolic syndrome in early pregnancy and risk of gestational diabetes mellitus. Chatzi L, Plana E, Pappas A, Alegkakis D, Karakosta P, Daraki V, Vassilaki M, Tsatsanis C, Kafatos A, Koutis A, Kogevinas M. Diabetes Metab. 2009 Dec;35(6):490-4. doi: 10.1016/j.diabet.2009.07.003.

Metabolic syndrome in early pregnancy and risk of preterm birth. Chatzi L, Plana E, Daraki V, Karakosta P, Alegkakis D, Tsatsanis C, Kafatos A, Koutis A, Kogevinas M. Am J Epidemiol. 2009 Oct 1;170(7):829-36. doi: 10.1093/aje/kwp211. Epub 2009 Aug 27.

The kinase Akt1 controls macrophage response to lipopolysaccharide by regulating microRNAs. Androulidaki A, Iliopoulos D, Arranz A, Doxaki C, Schworer S, Zacharioudaki V, Margioris AN, Tsichlis PN, Tsatsanis C. Immunity. 2009 Aug 21;31(2):220-31. doi: 10.1016/j.immuni.2009.06.024.

Corticotropin Releasing Factor promotes breast cancer cell motility and invasiveness. Androulidaki A, Dermitzaki E, Venihaki M, Karagianni E, Rassouli O, Andreakou E, Stournaras C, Margioris AN, Tsatsanis C. Mol Cancer. 2009 Jun 2;8:30. doi: 10.1186/1476-4598-8-30.

Adiponectin promotes endotoxin tolerance in macrophages by inducing IRAK-M expression. Zacharioudaki V, Androulidaki A, Arranz A, Vrentzos G, Margioris AN, Tsatsanis C. J Immunol. 2009 May 15;182(10):6444-51. doi: 10.4049/jimmunol.0803694.

Distinct roles of TLR4 and CD14 in LPS-induced inflammatory responses of neonates. Levy E, Xanthou G, Petrakou E, Zacharioudaki V, Tsatsanis C, Fotopoulos S, Xanthou M. Pediatr Res. 2009 Aug;66(2):179-84. doi: 10.1203/PDR.0b013e3181a9f41b.

Vaporidi K, Voloudakis G, Priniannakis G, Kondili E, Koutsopoulos A,Tsatsanis C, Georgopoulos D. Effects of respiratory rate on ventilator-induced lung injury at a constant PaCO2 in a mouse model of normal lung. Crit Care Med. 2008 Apr;36(4):1277-83. PubMed PMID: 18379255.

Arranz A, Androulidaki A, Zacharioudaki V, Martinez C, Margioris AN, Gomariz RP, Tsatsanis C. Vasoactive intestinal peptide suppresses toll-like receptor 4 expression in macrophages via Akt1 reducing their responsiveness to lipopolysaccharide. Mol Immunol. 2008 May;45(10):2970-80. PubMed PMID: 18336909.

Tsatsanis C, Vaporidi K, Zacharioudaki V, Androulidaki A, Sykulev Y, Margioris AN, Tsichlis PN. Tpl2 and ERK transduce antiproliferative T cell receptor signals and inhibit transformation of chronically stimulated T cells. Proc Natl Acad Sci U S A. 2008 Feb 26;105(8):2987-92 PubMed PMID: 18287049.

Tsatsanis C, Dermitzaki E, Venihaki M, Chatzaki E, Minas V, Gravanis A, Margioris AN. The corticotropin-releasing factor (CRF) family of peptides as local modulators of adrenal function. Cell Mol Life Sci. 2007 Jul;64(13):1638-55. Review. PubMed PMID: 17453142.

Dermitzaki E, Tsatsanis C, Minas V, Chatzaki E, Charalampopoulos I, Venihaki M, Androulidaki A, Lambropoulou M, Spiess J, Michalodimitrakis E, Gravanis A, Margioris AN. Corticotropin-releasing factor (CRF) and the urocortins differentially regulate catecholamine secretion in human and rat adrenals, in a CRF receptor type-specific manner. Endocrinology. 2007 Apr;148(4):1524-38 PubMed PMID: 17194738.

Charalampopoulos I, Alexaki VI, Tsatsanis C, Minas V, Dermitzaki E, Lasaridis I, Vardouli L, Stournaras C, Margioris AN, Castanas E, Gravanis A. Neurosteroids as endogenous inhibitors of neuronal cell apoptosis in aging. Ann N Y Acad Sci. 2006 Nov;1088:139-52. Review. PubMed PMID: 17192562.

Tsatsanis C, Zacharioudaki V, Androulidaki A, Dermitzaki E, Charalampopoulos I, Minas V, Gravanis A, Margioris AN. Peripheral factors in the metabolic syndrome: the pivotal role of adiponectin. Ann N Y Acad Sci. 2006 Nov;1083:185-95. PubMed PMID: 17148740.

Tsatsanis C, Androulidaki A, Dermitzaki E, Gravanis A, Margioris AN. Corticotropin releasing factor receptor 1 (CRF1) and CRF2 agonists exert an anti-inflammatory effect during the early phase of inflammation suppressing LPS-induced TNF-alpha release from macrophages via induction of COX-2 and PGE2. J Cell Physiol. 2007 Mar;210(3):774-83. PubMed PMID: 17117478.

Charalampopoulos I, Androulidaki A, Minas V, Chatzaki E, Tsatsanis C, Notas G, Xidakis C, Kolios G, Kouroumalis E, Margioris AN, Gravanis A. Neuropeptide urocortin and its receptors are expressed in rat Kupffer cells. Neuroendocrinology. 2006;84(1):49-57 PubMed PMID: 17090973.

Papadimitraki ED, Choulaki C, Koutala E, Bertsias G, Tsatsanis C, Gergianaki I, Raptopoulou A, Kritikos HD, Mamalaki C, Sidiropoulos P, Boumpas DT. Expansion of toll-like receptor 9-expressing B cells in active systemic lupus erythematosus: implications for the induction and maintenance of the autoimmune process. Arthritis Rheum. 2006 Nov;54(11):3601-11. PubMed PMID: 17075805.

Gravanis A, Makrigiannakis A, Chatzaki E, Zoumakis E, Tsatsanis C, Margioris AN. Stress neuropeptides in the human endometrium: paracrine effects on cell differentiation and apoptosis. Hormones (Athens). 2002 Jul-Sep;1(3):139-48. PubMed PMID: 17018441.

Dermitzaki I, Tsatsanis C, Alexaki VI, Castanas E, Margioris AN. Roles of protein kinase A (PKA) and PKC on corticotropin-releasing hormone (CRH)-induced elevation of cytosolic calcium from extra-and intra-cellular sources. Hormones (Athens). 2004 Oct-Dec;3(4):252-8. PubMed PMID: 16982600.

Tsatsanis C, Androulidaki A, Venihaki M, Margioris AN. Signalling networks regulating cyclooxygenase-2. Int J Biochem Cell Biol. 2006;38(10):1654-61. Review. PubMed PMID: 16713323.

Tsatsanis C, Androulidaki A, Alissafi T, Charalampopoulos I, Dermitzaki E, Roger T, Gravanis A, Margioris AN. Corticotropin-releasing factor and the urocortins induce the expression of TLR4 in macrophages via activation of the transcription factors PU.1 and AP-1. J Immunol. 2006 Feb 1;176(3):1869-77. PubMed PMID: 16424218.

Charalampopoulos I, Alexaki VI, Lazaridis I, Dermitzaki E, Avlonitis N, Tsatsanis C, Calogeropoulou T, Margioris AN, Castanas E, Gravanis A. G protein-associated, specific membrane binding sites mediate the neuroprotective effect of dehydroepiandrosterone. FASEB J. 2006 Mar;20(3):577-9. PubMed PMID: 16407456.

Panutsopulos D, Arvanitis DL, Tsatsanis C, Papalambros E, Sigala F, Spandidos DA. Expression of heregulin in human coronary atherosclerotic lesions. J Vasc Res. 2005 Nov-Dec;42(6):463-74 PubMed PMID: 16155362.

Vaporidi K, Tsatsanis C, Georgopoulos D, Tsichlis PN. Effects of hypoxia and hypercapnia on surfactant protein expression proliferation and apoptosis in A549 alveolar epithelial cells. Life Sci. 2005 Dec 5;78(3):284-93. PubMed PMID: 16125734.

Tsatsanis C, Zacharioudaki V, Androulidaki A, Dermitzaki E, Charalampopoulos I, Minas V, Gravanis A, Margioris AN. Adiponectin induces TNF-alpha and IL-6 in macrophages and promotes tolerance to itself and other pro-inflammatory stimuli. Biochem Biophys Res Commun. 2005 Oct 7;335(4):1254-63. PubMed PMID: 16115611.

Tsatsanis C, Androulidaki A, Dermitzaki E, Charalampopoulos I, Spiess J, Gravanis A, Margioris AN. Urocortin 1 and Urocortin 2 induce macrophage apoptosis via CRFR2. FEBS Lett. 2005 Aug 15;579(20):4259-64. PubMed PMID: 16054139.

Charalampopoulos I, Dermitzaki E, Vardouli L, Tsatsanis C, Stournaras C, Margioris AN, Gravanis A. Dehydroepiandrosterone sulfate and allopregnanolone directly stimulate catecholamine production via induction of tyrosine hydroxylase and secretion by affecting actin polymerization. Endocrinology. 2005 Aug;146(8):3309-18. PubMed PMID: 15860555.

Carruba G, Cocciadiferro L, Bellavia V, Rizzo S, Tsatsanis C, Spandidos D, Muti P, Smith C, Mehta P, Castagnetta L. Intercellular communication and human hepatocellular carcinoma. Ann N Y Acad Sci. 2004 Dec;1028:202-12. PubMed PMID:15650246.

Tsatsanis C, Spandidos DA. Oncogenic kinase signaling in human neoplasms. Ann N Y Acad Sci. 2004 Dec;1028:168-75. Review. PubMed PMID: 15650243.

Dermitzaki E, Tsatsanis C, Charalampopoulos I, Androulidaki A, Alexaki VI, Castanas E, Gravanis A, Margioris AN. Corticotropin-releasing hormone activates protein kinase C in an isoenzyme-specific manner. Biochem Biophys Res Commun. 2005 Feb 18;327(3):828-36. PubMed PMID: 15649420.

Christoforidou AV, Papadaki HA, Margioris AN, Eliopoulos GD, Tsatsanis C. Expression of the Tpl2/Cot oncogene in human T-cell neoplasias. Mol Cancer. 2004 Dec 3;3(1):34. PubMed PMID: 15575964

Papadaki HA, Tsatsanis C, Christoforidou A, Malliaraki N, Psyllaki M, Pontikoglou C, Miliaki M, Margioris AN, Eliopoulos GD. Alendronate reduces serum TNFalpha and IL-1beta, increases neutrophil counts, and improves bone mineral density and bone metabolism indices in patients with chronic idiopathic neutropenia (CIN)-associated osteopenia/osteoporosis. J Bone Miner Metab. 2004;22(6):577-87. PubMed PMID: 15490268.

Charalampopoulos I, Tsatsanis C, Dermitzaki E, Alexaki VI, Castanas E, Margioris AN, Gravanis A. Dehydroepiandrosterone and allopregnanolone protect sympathoadrenal medulla cells against apoptosis via antiapoptotic Bcl-2 proteins. Proc Natl Acad Sci U S A. 2004 May 25;101(21):8209-14. PubMed PMID: 15148390.

Chatzaki E, Charalampopoulos I, Leontidis C, Mouzas IA, Tzardi M, Tsatsanis C, Margioris AN, Gravanis A. Urocortin in human gastric mucosa: relationship to inflammatory activity. J Clin Endocrinol Metab. 2003 Jan;88(1):478-83. PubMed PMID: 12519893.

Agelaki S, Tsatsanis C, Gravanis A, Margioris AN. Corticotropin-releasing hormone augments proinflammatory cytokine production from macrophages in vitro and in lipopolysaccharide-induced endotoxin shock in mice. Infect Immun. 2002 Nov;70(11):6068-74. PubMed PMID: 12379683.

Spandidos DA, Sourvinos G, Tsatsanis C, Zafiropoulos A. Normal ras genes: their onco-suppressor and pro-apoptotic functions (review). Int J Oncol. 2002 Aug;21(2):237-41. Review. PubMed PMID: 12118316.

Dermitzaki E, Tsatsanis C, Gravanis A, Margioris AN. Corticotropin-releasing hormone induces Fas ligand production and apoptosis in PC12 cells via activation of p38 mitogen-activated protein kinase. J Biol Chem. 2002 Apr 5;277(14):12280-7. PubMed PMID: 11790788.

Patriotis C, Russeva MG, Lin JH, Srinivasula SM, Markova DZ, Tsatsanis C, Makris A, Alnemri ES, Tsichlis PN. Tpl-2 induces apoptosis by promoting the assembly of protein complexes that contain caspase-9, the adapter protein Tvl-1, and procaspase-3. J Cell Physiol. 2001 May;187(2):176-87. PubMed PMID: 11267997.

Dumitru CD, Ceci JD, Tsatsanis C, Kontoyiannis D, Stamatakis K, Lin JH, Patriotis C, Jenkins NA, Copeland NG, Kollias G, Tsichlis PN. TNF-alpha induction by LPS is regulated posttranscriptionally via a Tpl2/ERK-dependent pathway. Cell. 2000 Dec 22;103(7):1071-83. PubMed PMID: 11163183.

Sourvinos G, Tsatsanis C, Spandidos DA. Mechanisms of retrovirus-induced oncogenesis. Folia Biol (Praha). 2000;46(6):226-32. Review. PubMed PMID: 11140855.

Tsatsanis C, Spandidos DA. The role of oncogenic kinases in human cancer (Review). Int J Mol Med. 2000 Jun;5(6):583-90. Review. PubMed PMID: 10812005.

Sourvinos G, Tsatsanis C, Spandidos DA. Overexpression of the Tpl-2/Cot oncogene in human breast cancer. Oncogene. 1999 Sep 2;18(35):4968-73. PubMed PMID: 10490831.

Barr NI, Stewart M, Tsatsanis C, Fulton R, Hu M, Tsujimoto H, Neil JC. The fit-1 common integration locus in human and mouse is closely linked to MYB. Mamm Genome. 1999 Jun;10(6):556-9. PubMed PMID: 10341084.

Tsatsanis C, Patriotis C, Tsichlis PN. Tpl-2 induces IL-2 expression in T-cell lines by triggering multiple signaling pathways that activate NFAT and NF-kappaB. Oncogene. 1998 Nov 19;17(20):2609-18. PubMed PMID: 9840924.

Tsatsanis C, Patriotis C, Bear SE, Tsichlis PN. The Tpl-2 protooncoprotein activates the nuclear factor of activated T cells and induces interleukin 2 expression in T cell lines. Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):3827-32. PubMed PMID: 9520452.

Ceci JD, Patriotis CP, Tsatsanis C, Makris AM, Kovatch R, Swing DA, Jenkins NA, Tsichlis PN, Copeland NG. Tpl-2 is an oncogenic kinase that is activated by carboxy-terminal truncation. Genes Dev. 1997 Mar 15;11(6):688-700. PubMed PMID: 9087424.

Koffa M, Koumantakis E, Ergazaki M, Tsatsanis C, Spandidos DA. Association of herpesvirus infection with the development of genital cancer. Int J Cancer. 1995 Sep 27;63(1):58-62. PubMed PMID: 7558453.

Tsatsanis C, Fulton R, Nishigaki K, Tsujimoto H, Levy L, Terry A, Spandidos D, Onions D, Neil JC. Genetic determinants of feline leukemia virus-induced lymphoid tumors: patterns of proviral insertion and gene rearrangement. J Virol. 1994 Dec;68(12):8296-303. PubMed PMID: 7966623.

Gorgoulis V, Tsatsanis C, Ozanne B, Spandidos D. Detection of epidermal growth-factor receptor and C-erbb-2 gene amplification in transitional-cell bladder-carcinoma using the differential PCR technique. Int J Oncol. 1994 Jun;4(6):1191-7. PubMed PMID: 21567036.

Gorgoulis V, Giatromanolaki A, Karameris A, Tsatsanis C, Aninos D, Ozanne B, Veslemes M, Jordanoglou J, Trigidou R, Papastamatiou H, et al. Epidermal growth factor receptor expression in squamous cell lung carcinomas: an immunohistochemical and gene analysis in formalin-fixed, paraffin-embedded material. Virchows Arch A Pathol Anat Histopathol. 1993;423(4):295-302. PubMed PMID: 8236825.

Tsatsanis C, Tsiriyotis C, Spandidos DA. Hexamethylene bisacetamide and cis-platin stimulate the expression from the HIV-1 long terminal repeat sequence in human MCF-7 cells. In Vivo. 1992 Mar-Apr;6(2):145-9. PubMed PMID: 1525334.