Publications

Selected Publications

1.    Androulidaki A, Iliopoulos D, Arranz A, Doxaki C, Schworer S, Zacharioudaki V, Margioris AN, Tsichlis PN, Tsatsanis C. The kinase Akt1 controls macrophage response to lipopolysaccharide by regulating microRNAs. Immunity. 2009 Aug 21;31(2):220-31 (indexed as ‘Highly cited paper’-ISI).

2.    Arranz A., Doxaki C., Vergadi E.,  Martinez Y., Vaporidi K., Vanihaki M., Lagoudaki E., Stathopoulos E., Margioris A., Tsichlis PN and Tsatsanis C. Akt1 and Akt2 differentially contribute to macrophage polarization. Proc. Natl. Acad. Sci. USA, 2012 109(24):9517-22.

3.    Vergadi E, Ieronymaki E, Lyroni K, Vaporidi K, Tsatsanis C. Akt Signaling Pathway in Macrophage Activation and M1/M2 Polarization. J Immunol. 2017 Feb 1;198(3):1006-1014. (indexed as ‘Highly cited paper’-ISI).

4.    Lyroni K, Patsalos A, Daskalaki MG, Doxaki C, Soennichsen B, Helms M, Liapis I, Zacharioudaki V, Kampranis SC, Tsatsanis C. Epigenetic and Transcriptional Regulation of IRAK-M Expression in Macrophages. J Immunol. 2017 Feb 1;198(3):1297-1307.

5.    Silva MC, Davoli-Ferreira M, Medina TS, Sesti-Costa R, Silva GK, Lopes CD, Cardozo LE, Gava FN, Lyroni K, Dias FC, Frade AF, Baron M, Nakaya HI, Figueiredo F, Alves-Filho JC, Cunha FQ, Tsatsanis C, Chevillard C, Cunha-Neto E, Hirsch E, Silva JS, Cunha TM. Canonical PI3Kγ signaling in myeloid cells restricts Trypanosoma cruzi infection and dampens chagasic myocarditis. Nat Commun. 2018 Apr 17;9(1):1513.

6.    Alexaki VI, Fodelianaki G, Neuwirth A, Mund C, Kourgiantaki A, Ieronimaki E, Lyroni K, Troullinaki M, Fujii C, Kanczkowski W, Ziogas A, Peitzsch M, Grossklaus S, Sönnichsen B, Gravanis A, Bornstein SR, Charalampopoulos I, Tsatsanis C, Chavakis T. DHEA inhibits acute microglia-mediated inflammation through activation of the TrkA-Akt1/2-CREB-Jmjd3 pathway. Mol Psychiatry. 2018 Jun;23(6):1410-1420.

7.    Ieronymaki E, Theodorakis EM, Lyroni K, Vergadi E, Lagoudaki E, Al-Qahtani A, Aznaourova M, Neofotistou-Themeli E, Eliopoulos AG, Vaporidi K, Tsatsanis C. Insulin Resistance in Macrophages Alters Their Metabolism and Promotes an M2-Like Phenotype. J Immunol. 2019 Mar 15; 202(6):1786-1797.

8.    Ieronymaki E, Daskalaki MG, Lyroni K, Tsatsanis C. Insulin Signaling and Insulin Resistance Facilitate Trained Immunity in Macrophages Through Metabolic and Epigenetic Changes. Front Immunol. 2019;10:1330.

9.    Daskalaki MG, Bafiti P, Kikionis S, Laskou M, Roussis V, Ioannou E, Kampranis SC, Tsatsanis C. Disulfides from the Brown Alga Dictyopteris membranacea Suppress M1 Macrophage Activation by Inducing AKT and Suppressing MAPK/ERK Signaling Pathways. Mar Drugs. 2020;18(11):527. doi: 10.3390/md18110527.

10.    Pantazi I, Al-Qahtani AA, Alhamlan FS, Alothaid H, Matou-Nasri S, Sourvinos G, Vergadi E, Tsatsanis C. SARS-CoV-2/ACE2 Interaction Suppresses IRAK-M Expression and Promotes Pro-Inflammatory Cytokine Production in Macrophages. Front Immunol. 2021 Jun 23;12:683800.

11.    Kolliniati O, Ieronymaki E, Vergadi E, Tsatsanis C. Metabolic Regulation of Macrophage Activation. J Innate Immun. 2022;14(1):51-68. doi: 10.1159/000516780.

12.    Al-Qahtani AA, Pantazi I, Alhamlan FS, Alothaid H, Matou-Nasri S, Sourvinos G, Vergadi E, Tsatsanis C. SARS-CoV-2 modulates inflammatory responses of alveolar epithelial type II cells via PI3K/AKT pathway. Front Immunol. 2022 Oct 31;13:1020624.

13.    Mateska I, Witt A, Hagag E, Sinha A, Yilmaz C, Thanou E, Sun N, Kolliniati O, Patschin M, Abdelmegeed H, Henneicke H, Kanczkowski W, Wielockx B, Tsatsanis C, Dahl A, Walch AK, Li KW, Peitzsch M, Chavakis T, Alexaki VI. Succinate mediates inflammation-induced adrenocortical dysfunction. Elife. 2023 Jul 14;12:e83064.

14.    Vergadi, E., Kolliniati, O., Lapi, I., Ieronimaki, E., Lyroni, K., Alexaki, V. I., Diamantaki, E, Vaporidi, K., Papadaki, H, Galanakis, W, Hajishengallis, G., Chavakis, T., Tsatsanis, C.  An IL-10/DEL-1 axis supports granulopoiesis and survival from sepsis in early life. Nat. Commun. 2024, 5(1):680. doi: 10.1038/s41467-023-44178-y.