Κυριακή Σιδηροπούλου
Γνωστικές λειτουργίες, όπως η μνήμη εργασίας (ή εργαζόμενη μνήμη) και η μακρόχρονη μνήμη, αποτελούν χαρακτηριστικά των ανώτερης νοητικής λειτουργίας που έχει εξελιχθεί σημαντικά στα θηλαστικά, και κυρίως στον άνθρωπο. Νευροφυσιολογικοί μηχανισμοί που υποστηρίζουν αυτές τις διαδικασίες αποτελούν η παραμένουσα δραστηριότητα και η μακρόχρονη ενδυνάμωση. Τα ερευνητικά ενδιαφέροντα του εργαστηρίου μου εστιάζουν στη μελέτη αυτών των νευροφυσιολογικών μηχανισμών κατά τη διάρκεια της μεταγεννετικής ανάπτυξης, της μάθησης, μετά από στρες και σε παθολογικές καταστάσεις. Στόχος μας αποτελεί η ταυτοποίηση κυτταρικών διαδικασιών που καθιστούν επιρρεπείς τους παραπάνω μηχανισμούς κατά τη διάρκεια κρίσιμων περιόδων της ζωής και την ανάπτυξη μεθόδων πρόληψης ή αντιμετώπισης των νευροψυχιατρικών ασθενειών.
Chalkiadaki K, Velli A, Kyriazidis E, Stavroulaki V, Vouvoutsis V, Chatzaki E, Aivaliotis M, Sidiropoulou K. (2018) Development of the MAM model of schizophrenia in mice: Sex similarities and differences of hippocampal and prefrontal cortical function. Neuropharmacology 144:193-207.
Konstantoudaki X, Chalkiadaki K, Vasileiou E, Kalemaki K, Karagogeos D, Sidiropoulou K. (2018) Prefrontal cortical-specific differences in behavior and synaptic plasticity between adolescent and adult mice. Journal of Neurophysiology 119:822-833.
Konstantoudaki X, Chalkiadaki K, Tivodar S, Karagogeos D, Sidiropoulou K. (2016) Impaired synaptic plasticity in the prefrontal cortex of mice with developmentally decreased numbers of interneurons. Neuroscience 322:333-45.
Konstantoudaki X, Papoutsi A, Chalkiadaki K, Poirazi P, Sidiropoulou K. (2014) Modulatory effects of inhibition in a cortical microcircuit model. Frontiers in Neural Circuits 8:7.
Sidiropoulou K, Lu FM, Fowler MA, Xiao R, Phillips C, Ozkan ED, Zhu MX, White FJ, Cooper DC. (2009) Dopamine modulates an mGluR5-induced depolarization underlying prefrontal persistent activity. Nature Neuroscience 12:190-199.
Kalemaki K, Velli A, Christodoulou O, Denaxa M, Karagogeos D, Sidiropoulou K. (2021) The Developmental Changes in Intrinsic and Synaptic Properties of Prefrontal Neurons Enhance Local Network Activity from the Second to the Third Postnatal Weeks in Mice. Cereb Cortex. 2021 Dec 15:bhab438. doi: 10.1093/cercor/bhab438. Online ahead of print.
X. Konstantoudaki, K. Chalkiadaki, E. Vassileiou, K. Kalemaki, D. Karagogeos and K. Sidiropoulou (2018) Prefrontal cortical specific differences in behavior and synaptic plasticity between adolescent and adult mice, Journal of Neurophysiology, Mar 1;119(3):822-833. doi: 10.1152/jn.00189.2017. Epub 2017 Nov 22.
L. Zoupi, M. Savvaki, K. Kalemaki, I. Kalafatakis, K. Sidiropoulou and D. Karagogeos (2018) The function of Contactin-2/TAG-1 in oligodendrocytes in health and demyelinating pathology, Glia Mar;66(3):576-591. doi: 10.1002/glia.23266. Epub 2017 Nov 22..
V. Stavroulaki, E. Kazantzaki, P. Bitsios, K. Sidiropoulou and S.G. Giakoumaki (2017) The effects of working memory training on cognitive flexibility in man, Lecture notes in artificial intelligence, Conference paper in: Frasson C., Kostopoulos G. (eds) Brain Function Assessment in Learning. BFAL 2017. Lecture Notes in Computer Science, vol 10512. Springer, Chamin press, https://link.springer.com/chapter/10.1007/978-3-319-67615-9_7
V. Nikelotopoulou, K. Sidiropoulou, Y. Dalezios and N. Tavernarakis, BDNF regulates autophagy in the adult brain to coordinate metabolic status and adaptive behavior (2017), Cell Metabolism,Jul 5;26(1):230-242.e5. doi: 10.1016/j.cmet.2017.06.005
D.P. Ryan, K.S. Henzel, B.L. Pearson, M.E. Siwek, A. Papazoglou, K. Paesler, R. Müller, K. Xie, S. Schröder, L. Becker, L. Garrett, S.M. Hölter, F. Neff, I. Rácz, B. Rathkolb4, J. Rozman, G. Ehninger, M. Klingenspor, T. Klopstock, E. Wolf, W. Wurst, A. Zimmer, H. Fuchs, V. Gailus-Durner, M.H. de Angelis, K. Sidiropoulou, M. Weiergräber, and D. Ehninger (2017), A paternal methyl donor-rich diet altered cognitive and neural functions in offspring mice, Molecular Psychiatry, Apr 4. doi: 10.1038/mp.2017.53. [Epub ahead of print]
I. Sotiriou, K. Chalkiadaki, N. Christos, K. Sidiropoulou and E. Chatzaki (2017), Pharmacotherapy in smoking cessation: Corticotropin Releasing Factor receptors as emerging intervention targets, Neuropeptides, 2017 Feb 14. pii: S0143-4179(16)30137-8. doi: 10.1016/j.npep.2017.02.082.
E. Georgiou, K. Sidiropoulou, J. Richter, C. Papaneophytou, I. Sargiannidou, A. Kagiava, G. von Jonquieres, C. Christodoulou, M. Klugmann, K. Kleopas (2017) Gene therapy targeting oligodendrocytes provides therapeutic benefit in a leukodystrophy model, Brain, Jan 18. pii: aww351. doi: 10.1093/brain/aww351
X. Konstantoudaki, K. Chalkiadaki, S. Tivodar, D. Karagogeos and K. Sidiropoulou (2016) Impaired synaptic plasticity in the prefrontal cortex of mice with developmentally decreased numbers of interneurons, Neuroscience. 2016 Feb 26. pii: S0306-4522(16)00188-3. doi: 10.1016/j.neuroscience.2016.02.048.
P. Efstathopoulos, A. Kourgiantaki, K. Karali, K. Sidiropoulou, A.N. Margioris, A.Gravanis and I. Charalampopoulos (2015) Fingolimod induces neurogenesis in adult mouse hippocampus and improves contextual fear memory, Translational Psychiatry, Nov 24;5:e685. doi: 10.1038/tp.2015.179.
A. Papoutsi, K. Sidiropoulou and P. Poirazi (2014) Dendritic nonlinearities reduce network size requirements and mediate ON and OFF states of persistent activity in a PFC microcircuit model, PloS Comput Biol; 10(7): e1003764. doi: 10.1371 /journal.pcbi.1003764
X. Konstantoudaki, A. Papoutsi, K. Chalkiadaki, P. Poirazi and K. Sidiropoulou (2014) Modulatory effects of inhibition in a cortical microcircuit model, Frontiers in Neural Circuits, 8:7. doi: 10.3389/fncir.2014.00007.
A. Papoutsi, K. Sidiropoulou, V. Cutsuridis and P. Poirazi (2013) Induction and modulation of persistent activity in a layer V PFC microcircuit model, Frontiers in Neural Circuits, 7:161, doi: 10.3389/fncir.2013.00161.
K. Sidiropoulou and P. Poirazi (2012) Predictive features of persistent activity emergence in regular spiking and intrinsic bursting model neurons, PLoS Comput Biol, 8(4):e1002489.
E.K. Pissadaki, K. Sidiropoulou, M. Rezcko, P. Poirazi (2010) Encoding of spatio-termporal input characteristics by a CA1 pyramidal neuron model, PLoS Comput Biol. 16; 6(12):e1001038.
C. Shilyansky, K.H. Karlsgodt, D. Cummings, K. Sidiropoulou, M. Hardt, A.S. James, D. Ehninger, C.E. Bearden, P. Poirazi, J.D. Jentsch, T.D. Cannon, M.S. Levine, A.J. Silva (2010) Neurofibromin Regulates Corticostriatal Inhibitory Networks During Working Memory Performance, PNAS, 107(29):13141-6.
K. Sidiropoulou, E.D. Ozkan, M. Fowler, F.J. White, C. Philips, and D.C. Cooper (2009) Dopamine modulates an mGluR5-induced depolarization underlying prefrontal persistent activity, Nature Neuroscience, 2009, 12(2): 190-199
L. Liebmann, H. Karst, K. Sidiropoulou, N. van Gemert, O.C. Meijer, P. Poirazi, and Marian Joëls, Differential effects of corticosterone on the sAHP in the basolateral amygdala and CA1 region: Possible role of calcium channel subunits, J Neurophsl, 2008 Feb; 99(2):958-68.
M.A. Fowler, K. Sidiropoulou, E.D. Ozkan, C.W. Phillips, and D.C. Cooper (2006) Corticolimbic expression of TRPC4 and TRPC5 channels in the rodent brain is associated with an action potential burst-induced delayed afterdepolarization, Plos One, 2007 Jun 27; 2(6): e573.
K. Sidiropoulou, M. Joels and P. Poirazi (2006) Modeling stress-induced adaptations in Ca++ dynamics, Neurocomputing, doi:10.1016 /j.neucom.2006.10.068
K. Sidiropoulou, E. K. Pissadaki, and P. Poirazi (2006) Modeling single neuron computations, EMBO reports, 7(9): 880-885.
C. McClung, K. Sidiropoulou, M.H. Vitaterna, J.S. Takahashi, and F.J. White, and D.C. Cooper, E.J. Nestler (2005) Regulation of Dopaminergic Transmission and Cocaine Reward by the Clock Gene, PNAS, 102 (26): 9377-9381.
F.J. Nasif, K. Sidiropoulou, H-T Hu, and F.J. White (2004), Repeated Cocaine Administration Increases Membrane Excitability of Pyramidal Neurons in the Rat Medial Prefrontal Cortex, JPET, 312: 1305-1313.
K. Sidiropoulou, S. Chao, W.-X. Lu, and M.E. Wolf (2001), Amphetamine administration does not alter protein levels of the GLT-1 and EAAC1 glutamate transporter subtypes in rat midbrain, nucleus accumbens, striatum, or prefrontal cortex. Molecular Brain Res., 90:187-192.