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Παναγιώτης Ν. Μόσχου

Παναγιώτης Ν. Μόσχου

Ερευνητής IMBB (Αναπληρωτής Καθηγητής, Πανεπιστήμιο Κρήτης)
Ηλ. Ταχυδρομείο
Αυτή η διεύθυνση ηλεκτρονικού ταχυδρομείου προστατεύεται από τους αυτοματισμούς αποστολέων ανεπιθύμητων μηνυμάτων. Χρειάζεται να ενεργοποιήσετε τη JavaScript για να μπορέσετε να τη δείτε.
  
Αυτή η διεύθυνση ηλεκτρονικού ταχυδρομείου προστατεύεται από τους αυτοματισμούς αποστολέων ανεπιθύμητων μηνυμάτων. Χρειάζεται να ενεργοποιήσετε τη JavaScript για να μπορέσετε να τη δείτε.
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Ιστοσελίδα Εργαστηρίου
 

Μελετάμε βασικούς μηχανισμούς που ρυθμίζουν την ανάπτυξη, τη μετάβαση της κυτταρικής μοίρας και την προσαρμογή σε καταπονήσεις σε πληθυσμούς δυναμικών βλαστικών κυττάρων. Η έρευνά μας στοχεύει στην κατανόηση του τρόπου με τον οποίο τα βλαστοκύτταρα αντιλαμβάνονται ενδογενή ή εξωγενή σινιάλα και πώς αυτά αλληλοσυνδέονται με δομικές και μηχανικές ιδιότητες των κυττάρων.

Εστιάζουμε κυρίως στην ομοιοστασία πρωτεϊνών και μορίων RNA δίνοντας έμφαση σε καταβολικές διεργασίες. Το κύριο βιολογικό μας σύστημα είναι το μοντέλο Arabidopsis. Είμαστε πεπειραμένοι σε ένα ευρύ φάσμα πειραματικών μεθόδων κυτταρικής βιολογίας, βιοχημείας, γενετικής και γονιδιωματικής επεξεργασίας. Επιπλέον, προσπαθούμε να επεκτείνουμε τις βασικές μας γνώσεις στη βελτίωση ειδών Brassicaceae σημαντικά για την οικολογία, τα τρόφιμα και το βιοντίζελ (π.χ. ελαιοκράμβη, Camelina).

Ma Y, Guo H, Hu L, Pons Martinez P, Moschou PN, Cevik V, Ding P, Duxbury Z, Sarris PF, Jones JDG. (2018) Distinct modes of derepression of an Arabidopsis immune receptor complex by two different bacterial effectors. PNAS 115:10218-10227.

Minina EA, Reza SH, Gutierrez-Beltran E, Elander PH, Bozhkov PV, Moschou PN. (2017) The Arabidopsis homolog of Scc4/MAU2 is essential for embryogenesis. J. Cell Sci. 130:1051-1063.

Liu C, Moschou PN. (2017) Cutting in the middleman: hidden substrates at the interface between proteases and plant development. New Phytol. 218:916-922.

Moschou PN, Gutierrez-Beltran E, Bozhkov PV, Smertenko A. (2016) Separase Promotes Microtubule Polymerization by Activating CENP-E-Related Kinesin Kin7. Dev. Cell. 37:350-361.

Moschou PN, Savenkov EI, Minina EA, Fukada K, Reza HS, Gutierrez-Beltran E, Sanchez-Vera V, Suarez MF, Hussay PJ, Smertenko AP, Bozhkov PV. (2016) EXTRA SPINDLE POLES (Separase) controls anisotropic cell expansion in Norway spruce (Picea abies) embryos independently from its role in anaphase progression. New Phytol. 212:232-43.

Full publication list

Correspondence indicated by §; only accepted or published papers


2018

Ma Y., Guo H., Hu L., Pons Martinez P., Moschou P.N., Cevik V., Ding P., Duxbury Z., Sarris P.F., Jones J.D.G. 2018 Distinct modes of derepression of an Arabidopsis immune receptor complex by two different bacterial effectors. Proceedings of the National Academy of Sciences USA (in press)

Tornkvist A., Liu C., Moschou P.N. Proteolysis in Nitrogen metabolism: Emerging insights. Journal of Experimental Botany (in press)

§Liu C., Moschou P.N. Cutting in the middleman: hidden substrates at the interface between proteases and plant development. New Phytologist 10.1111/nph.14501

§Liu C., Moschou P.N. Phenotypic novelty by CRISPR in plants. Developmental Biology 10.1016/j.ydbio.2018.01.015

Minina E.A., Moschou P.N., Vetukuri R.R., Sanchez-Vera V., Cardoso C., Liu Q., Elander P.H., Dalman K., Beganovic M., Lindberg Yilmaz J., Marmon S., Shabala L., Suarez M.F., Ljung K., Novák O., Shabala S., Stymne S., Hofius D., Bozhkov P.V. Transcriptional stimulation of rate-limiting components of the autophagic pathway improves plant fitness. Journal of Experimental Botany 10.1093/jxb/ery010

§Moschou P.N. Determination of di–/polyamine oxidase activity in plants by an in-gel spermidine oxidation assay. Methods in Molecular Biology 10.1007/978-1-4939-7398-9_14

Dolfors F., Holmquist L., Moschou P.N., Dixelius C., Tzelepis G. The Rhizoctonia solani LysM and RlpA-like effector proteins contribute to virulence suppressing chitin-triggered immunity and hypersensitive response. Biorxiv 10.1101/395582

2017

§Minina E.A., Moschou P.N., Bozhkov P.V. Limited and digestive proteolysis: crosstalk between evolutionary conserved pathways. New Phytologist 10.1111/nph.14627

§Minina E.A., Reza S.H., Gutierrez-Beltran E., Elander P.H., Bozhkov P.V., Moschou P.N. The Arabidopsis homolog of Scc4/MAU2 is essential for embryogenesis. Journal of Cell Science 10.1242/jcs.196865

Minina E.A., Reza S.H., Gutierrez-Beltran E., Elander P.H., Bozhkov P.V., Moschou P.N. Highlight in Development: The Arabidopsis homolog of Scc4/MAU2 is essential for embryogenesis. Development, 144:e1.2-e1.2

§Liu C., Stael S., Gevaert K., Van Breusegem F., Bozhkov P.V., Moschou P.N. The Proteolytic Landscape of an Arabidopsis Separase-Deficient Mutant Reveals Novel Substrates Associated With Plant Development. Biorxiv 10.1101/140962

2016

§Gémes K., Kim Y.J., Park K.Y., Moschou P.N., Andronis E., Valassaki C., Roussis A., Roubelakis-Angelakis K.A. An NADPH-oxidase/polyamine oxidase feedback loop controls oxidative burst under salinity. Plant Physiology 10.1104/pp.16.01118

§Moschou P.N., Savenkov E.I., Minina E.A., Fukada K., Reza S.H., Gutierrez-Beltran E., Sanchez-Vera V., Suarez M.F., Hussey P.J., Smertenko A.P., Bozhkov P.V. EXTRA SPINDLE POLES (Separase) controls anisotropic cell expansion in Norway spruce (Picea abies) embryos independently of its role in anaphase progression. New Phytologist 10.1111/nph.14012

§Moschou P.N., Gutierrez-Beltran E., Bozhkov P.V., Smertenko A. Separase Promotes Microtubule Polymerization by Activating CENP-E-Related Kinesin Kin7. Developmental Cell 10.1016/j.devcel.2016.04.015

Mellidou I., Moschou P.N., Ioannidis N.E., Pankou C., Gėmes K., Valassakis C., Andronis E.A., Beris D., Haralampidis K., Roussis A., Karamanoli A., Matsi T., Kotzabasis K., Constantinidou H.-I., Roubelakis-Angelakis K.A. Silencing S-adenosyl-L-methionine decarboxylase (SAMDC) in Nicotiana tabacum points at a polyamine-dependent trade-off between growth and tolerance responses. Frontiers in Plant Science 10.3389/fpls.2016.00379

Zhu T., Moschou P.N., Alvarez J.M., Sohlberg J.J., Arnold S. WUSCHEL-RELATED HOMEOBOX 2 is important for protoderm and suspensor development in the gymnosperm Norway spruce. BMC Plant Biology 10.1186/s12870-016-0706-7

Smertenko A., Moschou P.N., Zhang L., Fahy D., Bozhkov P. Characterization of cytokinetic mutants using small fluorescent probes. Methods in Molecular Biology 10.1007/978-1-4939-3142-2_15

2015

§Gutierrez-Beltran E., Moschou P.N., Smertenko A.P., Bozhkov P.V. Tudor staphylococcal nuclease links formation of stress granules and processing bodies with mRNA catabolism in Arabidopsis. Plant Cell 10.1105/tpc.114.134494

Gutiérrez-Beltran E., Bozhkov P.V., Moschou P.N. Tudor staphylococcal nuclease plays two antagonistic roles in RNA metabolism under stress. Plant Signaling and Behavior 10.1080/15592324.2015.1071005

Alvarez J.M., Sohlberg J., Engström P., Zhu T., Englund M., Moschou P.N., von Arnold S. The WUSCHEL-RELATED HOMEOBOX 3 gene PaWOX3 regulates lateral organ formation in Norway spruce. New Phytologist 10.1111/nph.13536

2014

Andronis E.A., Moschou P.N., Toumi I., Roubelakis-Angelakis K.A. Peroxisomal polyamine oxidase and NADPH-oxidase cross-talk for ROS homeostasis which affects respiration rate in Arabidopsis thaliana. Frontiers in Plant Science 10.3389/fpls.2014.00132

§Moschou P.N., Roubelakis-Angelakis K.A. Polyamines and programmed cell death. Journal of Experimental Botany 10.1093/jxb/ert373

Zhu T., Moschou P.N., Alvarez J.M., Sohlberg J.J., Von Arnold S. WUSCHEL-RELATED HOMEOBOX 8/9 is important for proper embryo patterning in the gymnosperm Norway spruce. Journal of Experimental Botany 10.1093/jxb/eru371

2013

§Moschou P.N., Smertenko A.P., Minina E.A., Fukada K., Savenkov E.I., Robert S., Hussey P.J., Bozhkov P.V. The caspase-related protease separase (EXTRA SPINDLE POLES) regulates cell polarity and cytokinesis in Arabidopsis. Plant Cell 10.1105/tpc.113.113043

Minina E.A., Sanchez-Vera V., Moschou P.N., Suarez M.F., Sundberg E., Weih M., Bozhkov P.V. Autophagy mediates caloric restriction-induced lifespan extension in Arabidopsis. Aging Cell 10.1111/acel.12048

2012

Moschou P.N., Wu J., Cona A., Tavladoraki P., Angelini R., Roubelakis-Angelakis K.A. The polyamines and their catabolic products are significant players in the turnover of nitrogenous molecules in plants. Journal of Experimental Botany 10.1093/jxb/ers202

Moschou P.N., Bozhkov P.V. Separases: Biochemistry and function. Physiologia Plantarum 10.1111/j.1399-3054.2011.01550.x

*Fincato P., *Moschou P.N., *Ahou A., Angelini R., Roubelakis-Angelakis K.A., Federico R., Tavladoraki P. The members of Arabidopsis thaliana PAO gene family exhibit distinct tissue- and organ-specific expression pattern during seedling growth and flower development. Amino Acids 10.1007/s00726-011-0999-7 (*equal contributors)

2011

Tisi A., Federico R., Moreno S., Lucretti S., Moschou P.N., Roubelakis-Angelakis K.A., Angelini R., Cona A. Perturbation of polyamine catabolism can strongly affect root development and xylem differentiation. Plant Physiology 10.1104/pp.111.173153

§Moschou P.N., Roubelakis-Angelakis K.A. Characterization, assay, and substrate specificity of plant polyamine oxidases. Methods in molecular biology (Clifton, N.J.) 10.1007/978-1-61779-034-8_11

Fincato P., Moschou P.N., Spedaletti V., Tavazza R., Angelini R., Federico R., Roubelakis-Angelakis K.A., Tavladoraki P.    Functional diversity inside the Arabidopsis polyamine oxidase gene family. Journal of Experimental Botany 10.1093/jxb/erq341

2010

Paschalidis K.A., Toumi I., Moschou P.N., Roubelakis-Angelakis K.A. ABA-dependent amine oxidases-derived H2O2 affects stomata conductance. Plant Signaling and Behavior 10.4161/psb.5.9.12679

Wu J., Shang Z., Wu J., Jiang X., Moschou P.N., Sun W., Roubelakis-Angelakis K.A., Zhang S. Spermidine oxidase-derived H2O2 regulates pollen plasma membrane hyperpolarization-activated Ca2+-permeable channels and pollen tube growth. Plant Journal 10.1111/j.1365-313X.2010.04301.x

§Toumi I., Moschou P.N., Paschalidis K.A., Bouamama B., Ben Salem-fnayou A., Ghorbel A.W., Mliki A., Roubelakis-Angelakis K.A. Abscisic acid signals reorientation of polyamine metabolism to orchestrate stress responses via the polyamine exodus pathway in grapevine. Journal of Plant Physiology 10.1016/j.jplph.2009.10.022

§Moschou P.N., Roubelakis-Angelakis K.A. Polyamines in grapevine research. Methodologies and Results in Grapevine Research 10.1007/978-90-481-9283-0_13

2009

Paschalidis K.A., Moschou P.N., Aziz A., Toumi I., Roubelakis-Angelakis K.A. Polyamines in grapevine: An update. Grapevine Molecular Physiology and Biotechnology: Second Edition 10.1007/978-90-481-2305-6_8

Loulakakis K.A., Morot-Gaudry J.F., Velanis C.N., Skopelitis D.S., Moschou P.N., Hirel B., Roubelakis-Angelakis K.A. Advancements in nitrogen metabolism in grapevine Grapevine Molecular Physiology and Biotechnology: Second Edition 10.1007/978-90-481-2305-6_7

Labboun S., Tercé-Laforgue T., Roscher A., Bedu M., Restivo F.M., Velanis C.N., Skopelitis D.S., Moschou P.N., Roubelakis-Angelakis K.A., Suzuki A., Hirel B. Resolving the role of plant glutamate dehydrogenase. I. In vivo real time nuclear magnetic resonance spectroscopy experiments. Plant and Cell Physiology 10.1093/pcp/pcp155

Paschalidis K.A., Moschou P.N., Toumi I., Roubelakis-Angelakis K.A. Polyamine anabolic/catabolic regulation along the woody grapevine plant axis. Journal of Plant Physiology 10.1016/j.jplph.2009.03.013

Moschou P.N., Sarris P.F., Skandalis N., Andriopoulou A.H., Paschalidis K.A., Panopoulos N.J., Roubelakis-Angelakis K.A. Engineered polyamine catabolism preinduces tolerance of tobacco to bacteria and oomycetes. Plant Physiology 10.1104/pp.108.134932

2008

Moschou P.N., Sanmartin M., Andriopoulou A.H., Rojo E., Sanchez-Serrano J.J., Roubelakis-Angelakis K.A.    Bridging the gap between plant and mammalian polyamine catabolism: A novel peroxisomal polyamine oxidase responsible for a full back-conversion pathway in arabidopsis. Plant Physiology 10.1104/pp.108.123802

Moschou P.N., Delis I.D., Paschalidis K.A., Roubelakis-Angelakis K.A. Transgenic tobacco plants overexpressing polyamine oxidase are not able to cope with oxidative burst generated by abiotic factors. Physiologia Plantarum 10.1111/j.1399-3054.2008.01049.x

Moschou P.N., Paschalidis K.A., Delis I.D., Andriopoulou A.H., Lagiotis G.D., Yakoumakis D.I., Roubelakis-Angelakis K.A. Spermidine exodus and oxidation in the apoplast induced by abiotic stress is responsible for H2O2 signatures that direct tolerance responses in tobacco. Plant Cell 10.1105/tpc.108.059733

Toumi I., Gargouri M., Nouairi I., Moschou P.N., Salem-Fnayou A.B., Mliki A., Zarrouk M., Ghorbel A. Water stress induced changes in the leaf lipid composition of four grapevine genotypes with different drought tolerance. Biologia Plantarum 10.1007/s10535-008-0035-2

Moschou P.N., Paschalidis K.A., Roubelakis-Angelakis K.A. Plant polyamine catabolism: The state of the art. Plant Signaling and Behavior. 10.4161/psb.3.12.7172


MISCELLANEOUS

Moschou P.N., +83 authors. 2018. Regulating genome edited organisms as GMOs has negative consequences for agriculture, society and economy. Position paper. VIB, Belgium

K. A. Roubelakis-Angelakis KA, Moschou P.N., Sarris P.F., Panopoulos N.J. 2009. ALTERED POLYAMINE CATABOLISM: PRODUCING TRANSGENIC PLANTS WITH ENHANCED TOLERANCE TO BACTERIA AND OOMYCETES. INFORMATION SYSTEMS FOR BIOTECHNOLOGY.


PATENTS

P41503887SE00. Bozhkov P., Minina A., Stymne S., Moschou P.N., Hofius D; “Improving plant fitness through autophagy”.