Research in our lab (Aspergillus nidulans Molecular Genetics Laboratory) aims at:
• Genetically, biochemically and biophysically dissecting the structure-function relationships underlying transporter function, specificity and molecular evolution
• Identifying the pathways and molecular mechanisms involved in the membrane trafficking, exocytosis, endocytosis and turnover of specific transporters and other membrane cargoes in response to fungal growth and to various physiological or stress signals
• Studying the role of transporters in fungal pathogenicity and use in silico modelling of specific purine transporters for rational antifungal drug design.
Dimou S, Martzoukou O, Dionysopoulou M, Bouris V, Amillis S, Diallinas G. (2020) Translocation of nutrient transporters to cell membrane via Golgi bypass in Aspergillus nidulans. EMBO Rep. 21:e49929.
Papadaki GF, Lambrinidis G, Zamanos A, Mikros E, Diallinas G. (2019) Cytosolic N- and C-Termini of the Aspergillus nidulans FurE Transporter Contain Distinct Elements that Regulate by Long-Range Effects Function and Specificity. J Mol Biol. 431:3827-3844.
Martzoukou O, Amillis S, Zervakou A, Christoforidis S, Diallinas G. (2017) The AP-2 complex has a specialized clathrin-independent role in apical endocytosis and polar growth in fungi. Elife. 6:e20083.
Diallinas G. (2016) Dissection of Transporter Function: From Genetics to Structure. Trends Genet. 32:576-590.
Alguel Y, Amillis S, Leung J, Lambrinidis G, Capaldi S, Scull NJ, Craven G, Iwata S, Armstrong A, Mikros E, Diallinas G, Cameron AD, Byrne B. (2016) Structure of eukaryotic purine/H(+) symporter UapA suggests a role for homodimerization in transport activity. Nat Commun. 7:11336.