imbb logo for mobile



    What are we interested in?
    The brain tries to build an internal model of the environment based on information from multiple sensory systems, in order to guide future actions. Every day, we see thousands of unique objects with many different shapes, colors, sizes and textures. Each one of these objects can generate a virtually infinite number of different images on our retinas, depending on the conditions we view it under. In spite of this extraordinary variability, our brain can recognize objects in a fraction of a second and without any apparent effort. To accomplish this computationally challenging task, a large part of our brain is dedicated to processing all the available information from the environment and extracting and isolating object identities. Fundamentally, we want to understand how different circuits in cortical areas coordinate to perform this complicated computation.

    What methods do we use in our research?
    We use a combination of computational, behavioral, electrophysiological, two-photon and widefield imaging, and optogenetic techniques. We train mice to perform object discrimination tasks that require multiple kinds of sensory information. Importantly, we study the neural responses of awake animals to sensory stimuli both during passive tasks, and during behavior. Finally, we use computational models, to understand how the activities of large number of neurons generate invariant object representations, and to try to infer how different circuit architectures might underly this ability. The models give us greater insight into potential mechanistic interpretations and guide our next experiments.

    What are some of the questions we are studying?

    Mouse object recognition: Even though mice are considered nocturnal animals, there have been plenty of studies showing that mice can perform complicated visual tasks. However, due to the difficulties in training these animals on complicated tasks, there has been limited research in this area. A first step is to try to answer the question: “What are the visual object recognition capabilities of mice?” Can we develop tasks and objects that are easy for these animals to learn? How do the animals use this information to navigate? With the help of our high-throughput behavioral home-cage training system that runs on low-cost Raspberry Pi’s we can overcome the limitations of training individual animals and explore the parameter space for difficult tasks. Additionally, this automatic training method provides a good screening method for various cognitive deficits.

    Object representations across the visual hierarchy: One of the primary areas of research in our lab is to identify the visual areas that are critical for object recognition. How do the neural representations evolve across the visual hierarchy and how do cortical circuits across these areas interact? Does visual experience alter these representations? How are representations of multiple objects multiplexed across populations of neurons?

    Multimodal object recognition: Objects can elicit a plethora of sensory stimulation that may involve one or more senses; for example, a cat in the world has visual, olfactory, auditory, and somatosensory features.  Our brains have evolved to be able to assign these diverse features correctly to a single object base on constancy and correlation in the sensory input. Despite the fact that this is a central characteristic of our ability to identify objects, most studies on object recognition do not use such a rich stimulus set of information or include the dynamics of real existing objects. We are using multisensory information (olfactory, visual, auditory) to define objects that animals have to discriminate, and we are investigating the cortical areas and neural activity that are necessary to integrate these sensations into a single representation of an object.



    Andreas S. Tolias (Professor, Baylor College of Medicine Houston, TX US)
    Jacob Reimer (Assistant Professor, Baylor College of Medicine, Houston TX US)
    Dorina Papageorgiou (Assistant Professor, Baylor College of Medicine, Houston TX US)
    Philipp Berens (Professor, University of Tübingen, Germany)
    Alex Ecker (Professor, University of Göttingen, Germany)
    Fabian Sinz (Group Leader, University of Tübingen, Germany)