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Research News

DNA damage in microglia leads to neurodegeneration

IMBB researchers discovered DNA damage triggers cytosolic DNA buildup in microglia, provoking an immune reaction in mouse brain that triggers neuronal cell death. IMBB researchers devised an anti-inflammatory method to target microglia, remove cytosolic DNAs, and delay neurodegeneration onset.

[PNAS]

Profiling the dynamics of chromatin release of newly transcribed RNA

Transcription and processing of newly transcribed RNA are dynamic processes in the nucleus of human cells. A new study by researchers at IMBB and Helmholtz Center Munich profiled the kinetics of chromatin dissociation of RNA transcripts, and uncover features of long non-coding RNA processing. The results have implications for the design of effective RNA-based therapeutics.

[Cell Systems] [Press Release]

Age-dependent nuclear lipid droplet accumulation is a cellular hallmark of ageing

Interdisciplinary scientific collaboration between the Institute of Molecular Biology and Biotechnology (IMBB, FORTH), the Institute of Electronic Structure and Laser (IESL, FORTH) and the Medical School of National and Kapodistrian University of Athens (NKUA), sheds light into the molecular mechanisms that regulate nuclear lipid droplets accumulation during ageing.

[Aging Cell

Discovering a disinhibitory microcircuit responsible for contextual information processing in the hippocampus

IMBB and NYU researchers joined forces to study how the brain conveys important environmental cues and contexts such as novelty and reward information. Using dendritic electrophysiology recordings, optogenetic circuit mapping, and multi-compartment computational modeling they uncovered a disinhibitory microcircuit that gates dendritic spikes in hippocampal pyramidal neurons driven by lateral entorhinal cortex inputs. These inputs are among the first to be affected in Alzheimer's disease.

[Cell Reports]