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Nektarios Tavernarakis

Nektarios Tavernarakis

Research Director (Professor)
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The main focus of our research is the study of neuronal function and dysfunction, using the nematode Caenorhabditis elegans as a model organism. Among the specific interests of our lab are the molecular mechanisms of necrotic cell death in neurodegeneration and senescent decline, the molecular mechanisms of sensory transduction and integration by the nervous system, the interplay between cellular metabolism and ageing, and the development of novel genetic tools for C. elegans research.

Palikaras K, Lionaki E, Tavernarakis N. (2015) Coordination of mitophagy and mitochondrial biogenesis during ageing in Caenorhabditis elegans. Nature 521:525-528.

Kourtis N, Nikoletopoulou V, Tavernarakis N. (2012) Small heat shock proteins protect from heat stroke-associated neurodegeneration. Nature 490:213-218.

Artal-Sanz M, Tavernarakis N. (2009) Prohibitin couples diapause signaling to mitochondrial energy metabolism during ageing in Caenorhabditis elegans. Nature 461:793-797.

Syntichaki P, Troulinaki K, Tavernarakis N. (2007) eIF4E function in somatic cells modulates ageing in Caenorhabditis elegans. Nature 445:922-926.

Syntichaki P, Xu K, Driscoll M, Tavernarakis N. (2002) Specific aspartyl and calpain proteases are required for neurodegeneration in C. elegans. Nature 419:939-944.



Protein Metabolism and Homeostasis in Aging (2010) Edited by Nektarios Tavernarakis. Springer-Verlag New York Inc., Series: Advances in Experimental Medicine and Biology, New York, NY, USA.




Journal articles
























  • Buttner S., Habernig L., Broeskamp F., Ruli D, Vogtle F. N., Vlachos M., Macchi F., Kuttner V., Carmona-Gutierrez D., Eisenberg T., Ring J., Markaki M., Taskin A. A., Benke S., Ruckenstuhl C., Braun R., Van den Haute C., Bammens T., van der Perren A., Frohlich K.-U., Winderickx J., Kroemer G., Baekelandt V., Tavernarakis N., Kovacs G. G., Dengjel J., Mesinger C., Sigrist S. J. and Madeo F. (2013) Endonuclease G mediates a-synuclein cytotoxicity during Parkinson's disease. EMBO Journal, 32: 3041-3054.





































         Equal contribution by Kyrpides N. and Tavernarakis N.