IMBB

Molecular Biology of Unicellular Organisms Group


Introduction

The unicellular yeast is the most efficiently used eukaryotic system for the study of essential cellular functions and mechanisms as well as for studies on cellular physiology and biochemistry. Advanced methods in classical and molecular genetics are valuable tools, which coupled with biochemical techniques greatly facilitate the acquisition of answers to important biological questions. The DNA sequence of the yeast genome will soon be known, unravelling for the first time, among other chromosomal properties, the entire repertoire of genes of this eukaryotic organism. This will provide an additional tool for studies in this model system, alleviating the need for sequence analysis. Systematic functional analysis of the new genes will greatly facilitate the studies on multicellular organisms, since the basic molecular mechanisms of various housekeeping and conditional cellular functions studies in yeast are applicable to higher eukaryotes.

Our group is:

a) participating in the European Union projects of yeast genome sequencing and funcional analysis

b) involved in the molecular analysis of specific gene regulatory pathways in response to environmental changes; and c) studying components involved in global mechanisms for transcriptional repression and activation