Economou Lab-Teaching BIO1502/BIO1403
Recommended Textbooks: 1. Branden and Tooze, 1999 Introduction to Protein structure 2nd edition (home) 2. Petsko and Ringe, 2004 Protein structure and function (home) 3. Alberts et al, 2002 Molecular Biology of the Cell 4th edition (home) 4. Stryer, 2003 Biochemistry 5th edition (home); Greek translation 2004; Crete University Press (home) 5. Pollack, 2001 Cells and gels and the engines of life (home) Movies
Links
Further Reading: (** essential) Visualizing Proteins In the Cell (** essential) From single moleculues to ensembles Protein Import Mitochondrial/Chloroplast Pfanner and Geissler Rev Mol Cel Biol ** A highly readable and very complete review for import into mitos Abstract PDF Sickmann et al The most complete proteome of a cellular organelle (yeast mitochondrial proteome) Abstract PDF Wiedemann et al * A short review. Good first glimpse of the molecules and mechanisms involved in mito protein import Abstract PDF
Alder and Theg ** Energetics of protein import at its best! Not just for mitos and chloros, but for other membrane protein import systems as well Abstract PDF
Soll and Schleiff * All you need to know about Tocs and Tics(but no thylakoids) Abstract PDF
Kessler and Schleiff Why on earth use GTPases for chloro import? Abstract PDF
Robinson et al The third chloro membrane (thylakoids) Abstract PDF Protein export: Sec and bacterial pathogens **Pugsley AP, Francetic O, Driessen AJ, de Lorenzo V. (2004) Getting out: protein traffic in prokaryotes. Mol Microbiol. 52, 3-11. Abstract PDF Dalbey RE, Kuhn A. (2004) YidC family members are involved in the membrane insertion, lateral Abstract PDF Randall LL, Hardy SJ. (2002) SecB, one small chaperone in the complex milieu of the cell. Cell Mol Life Sci. 59, 1617-1623. Abstract PDF Keenan RJ, Freymann DM, Stroud RM, Walter P. (2001) The signal recognition particle. Annu Rev Biochem.70:755-775 **Clemons WM Jr, Menetret JF, Akey CW, Rapoport TA. (2004) Structural insight into the protein translocation channel. Abstract PDF **Vrontou and Economou, A. (2004) Structure and function of SecA, the preprotein translocase nanomotor.BBA Mol Cell Reviews (in press) Abstract PDF *Gauthier A, Thomas NA, Finlay BB. (2003) Bacterial injection machines. J Biol Chem. 278, 25273-25276. Abstract PDF Protein folding in the cell: chaperones Bukau B, Horwich AL. (1998) The Hsp70 and Hsp60 chaperone machines. Abstract PDF **Hartl FU, Hayer-Hartl M. (2002) Molecular chaperones in the cytosol: from nascent chain to folded protein. Abstract PDF Jason C. Young, Joseã M. Barral and F. Ulrich Hartl (2003) More than folding: localized functions Abstract PDF
Molecular motors/machines: linear/rotary/ribosome General machines: Alberts Cell 1998 ** If you only read one paper on mol machines read this one. Abstract PDF Taylor EB Wilson Lecture * A highly readable review, broad overview Abstract PDF General motors: Vale Cell 2003 * Good review, mainly linear motors Abstract PDF Vale and Milligan Science 2000 * Similar to above, highly illustrative Abstract PDF
Ribosome: Yusupov Science * An outstanding effort. The Xray structure of the ribosome. Abstract PDF Spahn Cell 2001 EM structure of ribosome Abstract PDF Beckmann Cell 2001 EM structure of ribosome peptide channel Abstract PDF Frank Chem Biol ** The ribosome as a machine Abstract PDF
Moore PB Biochem 2001 Historical and focused on the ribosome mechanism – useful comment on the Xray structure determination Abstract PDF Myosin: Okten NSMB 2004 The myosin hand over hand mechanism Abstract PDF
ATPase: Cross Nature 2004 **Short Comment on the rotary mechanism (Itoh paper see below) Abstract PDF
Itoh et al Nature 2004 * Fantastic work, insightful and technically outstanding Abstract PDF
Sambongi Science 2001 * similar to above. ATPase mechanism, now textbook material! Abstract PDF Stock et al Science 1999 Tour de force of Xray crystallography! A classic! Abstract PDF Ion channels Doyle et al Science 1998 ** A Nobel Prize worth of information! Abstract PDF Agre Nobel Lecture Read for historic perspective and fun Abstract PDF
MacKinnon A medical doctor saw the light and turned into a scientist turned into a Nobel Prize winner Abstract PDF
Facciotti TIBS 2004 A more general membrane signal transduction review Abstract PDF
Toyoshima * the Ca –pump Xray structure Abstract PDF Disease/Biotechnology Choi JH, Lee SY. (2004) Secretory and extracellular production of recombinant proteins using Escherichia coli. Appl Microbiol Biotechnol. 64, :625-635. Abstract PDF Steidler L, Hans W, Schotte L, Neirynck S, Obermeier F, Falk W, Fiers W, Remaut E. (2000) Treatment of murine colitis by Lactococcus lactis secreting interleukin-10. Science. 289, 1352-1355. Abstract PDF Dobson CM. (2002) Getting out of shape. Nature. 418, 729-730. Abstract PDF
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