George PATARGIAS
Biomedical Research Foundation
Academy of Athens
Date: December 16, 2014 @ 12:30
Location: Seminar Room 1 [FORTH's bldg]
Abstract
Dr George Patargias graduated from the Physics Department of the University of Crete in 2000. In 2004, he completed his PhD thesis on computational studies of membrane transport proteins at the Department of Biochemistry in the University of Oxford. He has done postdoctoral research at the University of Oxford, the University of Leeds and the University of South Florida using molecular modelling and computer simulations in structural studies of viral ion channels, enzymes and DNA-binding proteins. Currently, he is a postdoctoral research fellow at the Biomedical Research Foundation of the Academy of Athens where he is involved in the study of protein activation using molecular dynamics simulations and the development of small-molecule inhibitors with rational drug design methods.
Host: M. Kokkinidis
John IOANNIDIS
Professor, Stanford University School of Medicine
Honorary Member of the Foundation for Research and Technology-Hellas
Date: December 5, 2014 @ 12:00
Location: Main Amphitheater [FORTH's bldg]
Host: T. Fotsis
John S. PEZARIS
Ph.D.
Massachusetts General Hospital
Harvard Medical School
Date: December 4, 2014 @ 12:00
Location: Seminar Room 1 [FORTH's bldg]
Abstract
The field of visual prosthetics has concentrated primarily on two targets for stimulation, the retina and the primary visual cortex. The lateral geniculate nucleus of the thalamus, the relay station between these two areas, has been largely ignored because of the difficulty of surgical approach. The development of deep brain stimulation techniques for addressing pathologies of the midbrain has opened surgical access to the thalamus, and motivates a reconsideration of targets for visual prosthetics.
With this background, we have performed experiments in an animal model to demonstrate a proof of concept for a visual prosthesis based on thalamic microstimulation, followed by an experiment in a computer model to set basic engineering parameters for a thalamic visual prosthesis, in turn followed by a series of experiments with sighted humans to assess design performance. In this presentation we will review the compelling motivation for the thalamic approach, review the experimental results thus far, and provide a preview of future work.
Host: P. Poirazi
Maria FARSARI
Institute of Electronic Structure & Laser (IESL)
Foundation for Research and Technology - HELLAS (FORTH)
Date: November 21, 2014 @ 12:00
Location: Seminar Room 1 [FORTH's bldg]
Host: I. Siden-Kiamos
Christos ECONOMOU
Archaeological Research Laboratory
Stockholm University
Date: November 13, 2014 @ 13:00
Location: Seminar Room 1 [FORTH's bldg]
Host: D. Kafetzopoulos
Introduction: Giannis Zacharakis, FORTH - IESL
1. "Polarization second harmonic imaging of biological samples"
Speaker: Sotiris Psilodimitrakopoulos
Research Associate, FORTH-IESL
2. "Theory and applications of super-resolution optical microscopy: unravelling the ultra-structure and dynamics of molecular assemblies in cells".
Speaker: Orestis Faklaris
Deputy Director of ImagoSeine Imaging facility
Institut Jacques Monod - CNRS - Universite Paris Diderot
3. "Autofluorescence Single Photon and Multiphoton endo-microscopy and applications in the diagnosis of respiratory pathologies".
Speaker: Anikitos Garofalakis
Research Scientist, PARCC - Inserm U970, Paris, France
Date: October 31, 2014 @ 11:00
Location: Seminar Room 1 [FORTH's bldg]
Host: G. Zacharakis, In Vivo Imaging Lab
Achilleas GRAVANIS
Date: October 10, 2014 @ 12:00
Location: Seminar Room 1 [FORTH's bldg]
Ayse YARALI PAISIOS
Leibniz Institute of Neurobiology
Magdeburg, Germany
Date: October 13, 2014 @ 15:00
Location: "A Payatakes" Seminar Room [FORTH's bldg]
Host: C. Delidakis
Dr. Ioanna TRIVIAI
Junior Group Leader - Stem Cell Biology Group
Clinic of Stem Cell Transplantation, University Medical Center Hamburg
Eppendorf, Hamburg, Germany
And Heinrich – Pette Institut, Leibniz Institute for Experimental
Virology, Hamburg, Hamburg, Germany
Date: October 2, 2014 @ 15:00
Location: Seminar Room 1 [FORTH's bldg]
Abstract
Myeloproliferative neoplasms (MPN) are chronic hematological malignancies characterized by expansion of aberrant myeloid progenitors.
Primary myelofibrosis (PMF) has the worst prognosis of all MPN and involves massive disruption of the hematopoietic niche leading to fibrosis/osteosclerosis development and/or transformation to acute myeloid leukemia (AML). In our studies to elucidate the trigerring event in PMF we identified a neoplastic stem cell population in patient peripheral blood responsible for disease initiation and development in vivo. Identifying the neoplastic stem cells in myeloproliferating neoplasms will provide the basis to decipher complicated niche
interactions implicated in evolution of the chronic phase and leukemic transformation and introduce new therapeutical targets to eradicate the disease.
Host: D. Kafetzopoulos, E. G. Spanakis
Catherine FAIVRE-SARRAILH
Director of Research
Aix Marseille University, Faculté de Médecine Nord
Date: April 28, 2014 @ 12:00
Location: Seminar Room 1 [FORTH's bldg]
Host: D. Karagogeos
Eirini LIONAKI
Tavernarakisʼ Lab
Date: May 2, 2014 @ 12:00
Location: Seminar Room 1 [FORTH's bldg]
Dr. Maurizio De Pittà
EPI BEAGLE, INRIA Rhône-Alpes, Université de Lyon LIRIS, 69006
Villeurbane, France
Date: May 8, 2014 @ 12:00
Location: Seminar Room 1 [FORTH's bldg]
Abstract
In recent years, the simultaneous recognition that astrocytes sense neighboring neuronal activity and release neuroactive agents (or “gliotransmitters”) has been instrumental in the uncovering of the many possible roles played by these cells in the regulation of synaptic transmission and neuronal activity. These findings suggested that information travels and is processed not just in the neuronal circuitry but in an expanded neuron-glia network. However much remains elusive about the role of astrocyte signaling in brain computation. Inspired by recent experiments on neuron-astrocyte interactions at cortical synapses, I will present theoretical arguments that suggest novel possible mechanisms whereby astrocytes could take part in the processing and storage of information by the brain. From subcellular to network levels, the analysis of the signaling pathways underlying these mechanisms refines our notion of neural communication and has profound implications on our understanding of brain function.
Host: Y. Poirazi
Ioanna TINIAKOU
Kardassisʼ Lab
Date: May 9, 2014 @ 12:00
Location: Seminar Room 1 [FORTH's bldg]
Myrto DENAXA
Molecular Neurobiology
National Institute for Medical Research, MRC, Mill Hill, London
Date: May 21, 2014 @ 12:00
Location: “A Payatakes” Seminar Room, FORTHʼs bldg
Host: D. Karagogeos
Panagiotis FILIPPAKOPOULOS
University Research Lecturer
Wellcome Trust Career Development Fellow
Structural Genomics Consortium & Ludwig Institute of Cancer Research
Nuffield Department of Clinical Medicine, University of Oxford
Date: May 29, 2014 @ 12:00
Location: Seminar Room 1 [FORTH's bldg]
Host: M. Kokkinidis & K. Kalantidis
Theofanis KARAYANNIS
Smilow Neuroscience and NYU Neuroscience Institute
NYU School of Medicine, USA
Date: June 3, 2014 @ 12:00
Location: "A Payatakes" Seminar Room [FORTH's bldg]
Host: D. Karagogeos
Maria SAVAKI
Karagogeos' Lab
Date: June 6, 2014 @ 12:00
Location: Seminar Room 1 [FORTH's bldg]
Christoforos NIKOLAOU
Assistant Professor, Department of Biology
University of Crete
Date: July 4, 2014 @ 12:00
Location: Seminar Room 1 [FORTH's bldg]
Host: C. Spilianakis
Jin HAILING
Professor, University of California, Riverside, USA
Date: July 11, 2014 @ 12:00
Location: Seminar Room 1 [FORTH's bldg]
Host: K. Kalantidis
Vassilis PAPADAKIS
Institute of Electronic Structure & Laser (IESL)
Foundation for Research and Technology - HELLAS (FORTH)
Date: July 25, 2014 @ 12:00
Location: Seminar Room 1 [FORTH's bldg]
Host: I. Siden-Kiamos
Pandelis PERAKAKIS
Laboratory of Experimental Economics
University of Granada, Spain
Date: August 19, 2014 @ 12:00
Location: "A Payatakes" Seminar Room [FORTH's bldg]
Host: Y. Poirazi
George Z MENTIS
Assistant Professor
The Center for Motor Neuron Biology and Disease
Columbia University
Date: September 2, 2014 @ 12:00
Location: Seminar Room 1 [FORTH's bldg]
Host: N. Tavernarakis
Petra FROMME
Professor of Chemistry and Biochemistry
Paul V Galvin Professor
Department of Chemistry and Biochemistry Director, Biodesign Center for Applied Structural Discovery Director of the Center for Membrane Proteins in Infectious Diseases Arizona State University
Date: September 25, 2014 @ 13:00
Location: Seminar Room 1 [FORTH's bldg]
Background
Structure determination of proteins and other macromolecules has historically required the growth of high-quality crystals sufficiently large to diffract X-rays efficiently. The applicability of the method has been limited by radiation damage and time resolution. The recently developed technique of Serial femtosecond X-ray crystallography (SFX) an X-ray free-electron laser (XFEL) to obtain high-resolution structural information from microcrystals has overcome these limitations.
Host: M. Kokkinidis, InnovCrete project
Marios CHATZIGEORGIOU
Career Development Fellow
MRC Laboratory of Molecular Biology
Cambridge, United Kingdom
Date: September 26, 2014 @ 12:00
Location: Seminar Room 1 [FORTH's bldg]
Host: C. Delidakis
Alekos ATHANASIADIS
Protein - Nucleic Acids Interactions Lab
Instituto Gulbenkian de Ciencia
Oeiras, Portugal
Date: January 8, 2014 @ 12:00
Location: Seminar Room 1 [FORTH's bldg]
Host: K. Kalantidis
Curra CHIARRA
Siden-Kiamos' Lab
Date: January 17, 2014 @ 12:00
Location: Seminar Room 1 [FORTH's bldg]
Vassilis CUTSURIDIS
Poirazi's Lab
Date: January 24, 2014 @ 12:00
Location: Seminar Room 1 [FORTH's bldg]
Abstract
The rodent hippocampus is one of the most studied brain regions. The hippocampus plays an important role in the encoding, retrieval and consolidation of spatial and episodic memories. Although much is known about the anatomical, physiological and molecular characteristics as well as the connectivity and synaptic properties of various cell types in the hippocampal microcircuits, how these detailed properties of individual neurons give rise to the encoding, retrieval and consolidation of memories remains unclear. Computational models play an instrumental role in providing clues on how these processes may take place.
In this talk, I will present three computational models of the region CA1 of the hippocampus at various levels of detail (Cutsuridis et al. (2010) Hippocampus 20(3): 423-446; Cutsuridis and Hasselmo (2012) Hippocampus 22: 1597-1621; Saravanan et al., under review). Issues such as memory capacity, recall performance, memory replay, and phase precession during various brain rhythms and in the presence of neuromodulation and various types of inhibitory interneurons will be addressed. My models lead to a number of experimentally testable predictions that may lead to a better understanding of the biophysical computations in the rodent hippocampus.
Giannis ZACHARAKIS
In vivo Imaging Lab (IVIL)
Laser Interactions and Photonics Division
Institute of Electronic Structure and Laser (IESL)
Date: January 31, 2014 @ 12:00
Location: Seminar Room 1 [FORTH's bldg]
Host: N. Kretsovali
Ioannis TSAMARDINOS
Bioinformatics Laboratory (BIL)
FORTH-ICS & Computer Science Department
University of Crete
Date: February 7, 2014 @ 12:00
Location: Seminar Room 1 [FORTH's bldg]
Host: I. Siden-Kiamos
George FILIPPIDIS
Institute of Electronic Structure & Laser (IESL)
Foundation for Research & Technology - Hellas (FORTH)
Date: February 21, 2014 @ 12:00
Location: Seminar Room 1 [FORTH's bldg]
Host: I. Siden-Kiamos
Detlev SCHILD
Director, Department of Neurophysiology and Cellular Biophysics
Goettingen University Medical School
and
Bernstein Center for Computational Neuroscience
Goettingen, Germany
Date: February 25, 2014 @ 12:00
Location: A. Payatakes" Seminar Room [FORTH's bldg]
Host: Y. Poirazi
Pavlos PAVLIDIS
Poirazi's Lab
Date: February 28, 2014 @ 12:00
Location: Seminar Room 1 [FORTH's bldg]
Apostolos DOLLAS
Technical University of Crete
Date: March 5, 2014 @ 12:00
Location: Seminar Room 1 [FORTH's bldg]
Host: Y. Poirazi
Antonios DOUGALIS
University of Manchester
Date: March 7, 2014 @ 12:00
Location: Seminar Room 1 [FORTH's bldg]
Host: Y. Poirazi
Jorgen KJEMS
Director of Interdisciplinary Nanoscience Center (iNANO)
Director of Lundbeck Nanomedicine Center (LUNA)
Interdisciplinary Nanoscience Center (iNANO)
Department of Molecular Biology and Genetics Aarhus University, Denmark
Date: March 14, 2014 @ 12:00
Location: Seminar Room 1 [FORTH's bldg]
Host: E. Gizeli
Callina STRATIGI
Spilianakis’ Lab
Date: March 21, 2014 @ 12:00
Location: Seminar Room 1 [FORTH's bldg]
Emmanuel STRATAKIS
Institute of Electronic Structure & Laser (IESL)
Foundation for Research and Technology - HELLAS (FORTH)
Date: March 31, 2014 @ 12:00
Location: Seminar Room 1 [FORTH's bldg]
Host: N. Kretsovali
Simona TIVODAR
Karagogeosʼ Lab
Date: April 11, 2014 @ 12:00
Location: Seminar Room 1 [FORTH's bldg]