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    Publications

    Publications since 2000

    Basagiannis D, Zografou S, Murphy C, Fotsis T, Morbidelli L, Ziche M, Bleck C, Mercer J, Christoforidis S. VEGF induces signalling and angiogenesis by directing VEGFR2 internalisation via macropinocytosis. J Cell Sci 129 (2016) 4091-4104.
    https://www.ncbi.nlm.nih.gov/pubmed/27656109

    Tsolis K, Bagli E, Kanaki K, Zografou S, Carpentier S, Bei E, Christoforidis S, Zervakis M, Murphy C, Fotsis T, Economou A. Proteome changes during transition from human embryonic to vascular progenitor cells. J Proteome Research 15 (2016) 1995-2007.
    https://www.ncbi.nlm.nih.gov/pubmed/27146950

    Kyrkou A, Stellas D, Syrrou M, Klinakis A, Fotsis T, Murphy C: Generation of human induced pluripotent stem cells in defined, feeder-free conditions. Stem Cell Research, 17 (2016) 458-460.
    https://www.sciencedirect.com/science/article/pii/S1873506116300381

    Kouroupis D, Kyrkou A, Triantafyllidi E, Katsimpoulas M, Chalepakis G, Goussia A,  Georgoulis A, Murphy C, Fotsis T: Generation of stem cell-based bioartificial anterior cruciate ligament (ACL) grafts for effective ACL rupture repair. Stem Cell Research 17 (2016) 448-457.
    https://www.ncbi.nlm.nih.gov/pubmed/27217303

    Karali E, Bellou S, Stellas D, Klinakis A, Murphy C, Fotsis T: ER mediates induction of endothelial cell survival and angiogenesis by VEGF: PLCg via mTORC1 activates ATF6 and PERK. Mol Cell 54 (2014) 559-72.
    https://www.ncbi.nlm.nih.gov/pubmed/24746698

    Kostaras E, Pedersen NM, Stenmark H, Fotsis T, Murphy C: SARA and RNF11 at the crossroads of EGFR signalling and trafficking. Methods Enzymol 535 (2014) 225-47.
    https://www.ncbi.nlm.nih.gov/pubmed/24377927

    Bellou S, Pentheroudakis G, Murphy C, Fotsis T: Anti-angiogenesis in cancer therapy: Hercules and Hydra. Cancer Lett. 338 (2013) 291-28.
    https://www.ncbi.nlm.nih.gov/pubmed/23707856

    Kyrkou A, Soufi M, Bahtz R, Ferguson C, Bai M, Parton RG, Hoffmann I, Zerial M, Fotsis T, Murphy C: RhoD participates in the regulation of cell-cycle progression and centrosome duplication. Oncogene 2013, 32:1831-1842.
    https://www.ncbi.nlm.nih.gov/pubmed/22665057

    Kyrkou A, Soufi M, Bahtz R, Ferguson C, Bai M, Parton RG, Hoffmann I, Zerial M, Fotsis T, Murphy C: The RhoD to centrosomal duplication. Small GTPases 2013, 4.
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3747252/

    Kostaras E, Sflomos G, Pedersen NM, Stenmark H, Fotsis T, Murphy C: SARA and RNF11 interact with each other and ESCRT-0 core proteins and regulate degradative EGFR trafficking. Oncogene 32 (2013) 5220-32.
    https://www.ncbi.nlm.nih.gov/pubmed/23222715

    Bellou S, Karali E, Bagli E, Al-Maharik N, Morbidelli L, Ziche M, Adlercreutz H, Murphy C, Fotsis T: The isoflavone metabolite 6-methoxyequol inhibits angiogenesis and suppresses tumor growth. Mol Cancer 2012, 11:35.
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3406996/

    Sflomos G, Kostaras E, Panopoulou E, Pappas N, Kyrkou A, Politou AS, Fotsis T, Murphy C: ERBIN is a new SARA-interacting protein: competition between SARA and SMAD2 and SMAD3 for binding to ERBIN. J Cell Sci 2011, 124:3209-3222.
    https://www.ncbi.nlm.nih.gov/pubmed/21878490

    Bellou S, Hink MA, Bagli E, Panopoulou E, Bastiaens PI, Murphy C, Fotsis T: VEGF autoregulates its proliferative and migratory ERK1/2 and p38 cascades by enhancing the expression of DUSP1 and DUSP5 phosphatases in endothelial cells. Am J Physiol Cell Physiol 2009, 297:C1477-1489.
    https://www.ncbi.nlm.nih.gov/pubmed/19741200

    Kardassis D, Murphy C, Fotsis T, Moustakas A, Stournaras C: Control of transforming growth factor beta signal transduction by small GTPases. FEBS J 2009, 276:2947-2965.
    https://www.ncbi.nlm.nih.gov/pubmed/19490100

    Murphy C: Endo-fin-ally a SARA for BMP receptors. J Cell Sci 2007, 120:1153-1155.

    Fyhrquist P, Mwasumbi L, Vuorela P, Vuorela H, Hiltunen R, Murphy C, Adlercreutz H: Preliminary antiproliferative effects of some species of Terminalia, Combretum and Pteleopsis collected in Tanzania on some human cancer cell lines. Fitoterapia 2006, 77:358-366.
    https://www.ncbi.nlm.nih.gov/pubmed/16797142

    Papanikolaou A, Papafotika A, Murphy C, Papamarcaki T, Tsolas O, Drab M, Kurzchalia TV, Kasper M, Christoforidis S: Cholesterol-dependent lipid assemblies regulate the activity of the ecto-nucleotidase CD39. J Biol Chem 2005, 280:26406-26414.
    https://www.ncbi.nlm.nih.gov/pubmed/15890655

    Panopoulou E, Murphy C, Rasmussen H, Bagli E, Rofstad EK, Fotsis T: Activin A suppresses neuroblastoma xenograft tumor growth via antimitotic and antiangiogenic mechanisms. Cancer Res 2005, 65:1877-1886.
    https://www.ncbi.nlm.nih.gov/pubmed/15753386

    Bagli E, Stefaniotou M, Morbidelli L, Ziche M, Psillas K, Murphy C, Fotsis T: Luteolin inhibits vascular endothelial growth factor-induced angiogenesis; inhibition of endothelial cell survival and proliferation by targeting phosphatidylinositol 3'-kinase activity. Cancer Res 2004, 64:7936-7946.
    https://www.ncbi.nlm.nih.gov/pubmed/15520200

    Panopoulou E, Gillooly DJ, Wrana JL, Zerial M, Stenmark H, Murphy C, Fotsis T: Early endosomal regulation of Smad-dependent signalling in endothelial cells. J Biol Chem 2002, 277:18046-18052.
    https://www.ncbi.nlm.nih.gov/pubmed/11877415

    Karetsou Z, Kretsovali A, Murphy C, Tsolas O, Papamarcaki T: Prothymosin alpha interacts with the CREB-binding protein and potentiates transcription. EMBO Rep 2002, 3:361-366.
    https://www.ncbi.nlm.nih.gov/pubmed/11897665

    Hatzi E, Murphy C, Zoephel A, Rasmussen H, Morbidelli L, Ahorn H, Kunisada K, Tontsch U, Klenk M, Yamauchi-Takihara K, et al.: N-myc oncogene overexpression down-regulates IL-6; evidence that IL-6 inhibits angiogenesis and suppresses neuroblastoma tumor growth. Oncogene 2002, 21:3552-3561.
    https://www.ncbi.nlm.nih.gov/pubmed/12032857

    Hatzi E, Murphy C, Zoephel A, Ahorn H, Tontsch U, Bamberger AM, Yamauchi-Takihara K, Schweigerer L, Fotsis T: N-myc oncogene overexpression down-regulates leukemia inhibitory factor in neuroblastoma. Eur J Biochem 2002, 269:3732-3741.
    https://www.ncbi.nlm.nih.gov/pubmed/12153570

    Murphy C, Saffrich R, Olivo-Marin JC, Giner A, Ansorge W, Fotsis T, Zerial M: Dual function of rhoD in vesicular movement and cell motility. Eur J Cell Biol 2001, 80:391-398.
    https://www.ncbi.nlm.nih.gov/pubmed/11484930

    Hatzi E, Breit S, Zoephel A, Ashman K, Tontsch U, Ahorn H, Murphy C, Schweigerer L, Fotsis T: MYCN oncogene and angiogenesis: down-regulation of endothelial growth inhibitors in human neuroblastoma cells. Purification, structural, and functional characterization. Adv Exp Med Biol 2000, 476:239-248.
    https://www.ncbi.nlm.nih.gov/pubmed/10949669