Publications
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Kontaki H, Koukaki M, Vasilarou M, Giakountis A, Deligianni E, Luo X, Kim Y, Talianidis I. (2021) Targeting Smyd3 by next-generation antisense oligonucleotides suppresses liver tumor growth. iScience. 24:102473.
Karagianni P, Moulos P, Schmidt D, Odom DT, Talianidis I. (2020) Bookmarking by Non-pioneer Transcription Factors during Liver Development Establishes Competence for Future Gene Activation. Cell Rep. 30:1319-1328.e6.
Nikolaou KC., Moulos P., Harokopos V., Chalepakis G., Talianidis I. (2017) Kmt5a Controls Hepatic Metabolic Pathways by Facilitating RNA Pol II Release from Promoter-Proximal Regions. Cell Rep. 20: 909-922.
Giakountis A., Moulos P., Sarris ME., Hatzis P., Talianidis I. (2017) Smyd3-associated regulatory pathways in cancer. Semin Cancer Biol. 42:654-663.
Elkouris M., Kontaki H., Stavropoulos A., Anastasia Antonoglou A., Nikolaou KC., Samiotaki M., Szantai E., Brown PJ., Sideras P., Panayotou G., Talianidis I. (2016) SET9-mediated regulation of TGF-b signaling links protein methylation to pulmonary fibrosis. Cell Rep. 15:2733-2744.
Sarris ME, Moulos P, Haroniti A, Giakountis A., Talianidis I. (2016) Smyd3 is a transcriptional potentiator of multiple cancer-promoting genes and required for liver and colon cancer development. Cancer Cell 29:354-366.
Lugli N, Kamileri I, Keogh A, Malinka T, Sarris M, Talianidis I, Schaad O, Candinas D, Stroka D, and Halazonetis TD. (2016) R-spondin 1 and noggin facilitate expansion of resident stem cells from non-damaged gallbladders. EMBO Rep. 17:769-779.
Nikolaou KC, Moulos P, Chalepakis G, Hatzis P, Oda H, Reinberg D, Talianidis I. (2015) Spontaneous development of hepatocellular carcinoma with cancer stem cell properties in PR-SET7-deficient livers. EMBO J. 34:430-447.
Schmitt BM, Rudolph KL, Karagianni P, Fonseca NA, White RJ, Talianidis I, Odom DT, Marioni JC, Kutter C. (2014) High-resolution mapping of transcriptional dynamics across tissue development reveals a stable mRNA-tRNA interface. Genome Res. 24:1797-1807.
Duteil D., Metzger E., Willmann D., Karagianni P., Friedrichs N., Greschik H., Günther T., Buettner R., Talianidis I., Metzger D., Schüle R. (2014) LSD1 promotes oxidative metabolism of white adipose tissue. Nature Comm. 5:4093
Sarris M, Nikolaou K, Talianidis I. (2014) Context-specific regulation of cancer epigenomes by histone and transcription factor methylation. Oncogene 33:1207-1217.
Nikolaou K, Sarris M, Talianidis I. (2013) Molecular pathways: the complex roles of inflammation pathways in the development and treatment of liver cancer. Clin Cancer Res. 19:2810-2816.
Stefflova K., Thyber D., Wilson MD., Streeter I., Aleksic J., Karagianni P., Brazma A., Adams DJ., Talianidis I., Marioni JC., Flicek P., Odom DT. (2013) Cooperativity and Rapid Evolution of Cobound Transcription Factors in Closely Related Mammals. Cell 154:530-540.
Nikolaou K., Tsagaratou A., Eftychi C., Kollias G., Mosialos G., Talianidis I. (2012) Inactivation of the deubiquitinase CYLD in hepatocytes causes apoptosis, inflammation, fibrosis and cancer. Cancer Cell 21:738-75
Kontaki H., Talianidis I. (2010) Lysine methylation regulates E2F1-induced cell death. Mol Cell 39:152-160.
Schmidt D, Wilson MD, Ballester B, Schwalie PC, Brown GD, Marshall A, Kutter C, Watt S, Martinez-Jimenez CP, Mackay S, Talianidis I, Flicek P, Odom DT. (2010) Five-Vertebrate ChIP-seq Reveals the Evolutionary Dynamics of Transcription Factor Binding. Science 328:1036-1040.
Martinez-Jimenez CP, Kyrmizi I, Cardot P, Gonzalez FJ, Talianidis I. (2010) Hepatocyte nuclear factor 4alpha coordinates a transcription factor network regulating hepatic fatty acid metabolism. Mol Cell Biol. 30:565-577.
Tatarakis A, Margaritis T, Martinez-Jimenez CP, Kouskouti A, Mohan WS 2nd, Haroniti A, Kafetzopoulos D, Tora L, Talianidis I. (2008) Dominant and redundant functions of TFIID involved in the regulation of hepatic genes. Mol Cell 31:531-543.