Christos Tsatsanis
Our research aims to delineate the molecular mechanisms regulating inflammation and inflammatory diseases and identify biomarkers and therapeutic targets. In this context the lab analyzes mechanisms regulating activation and inactivation of macrophages at the level of signal transduction, cell metabolism and epigenetics. How metabolic changes at the level of organism (obesity, insulin resistance, microbiome) or at the cellular level (expression of signaling regulators or epigenetic modulators) affect innate immune training and alter responses to pathogens or other inflammatory triggers is investigated. The impact of nutrition on shaping innate immune responses and trained immunity is studied. The lab also focuses in the identification of circulating non-coding RNAs as biomarkers of inflammation-related disorders.
Vergadi E, Kolliniati O, Lapi I, Ieronymaki E, Lyroni K, Alexaki VI, Diamantaki E, Vaporidi K, Hatzidaki E, Papadaki HA, Galanakis E, Hajishengallis G, Chavakis T, Tsatsanis C. (2024) An IL-10/DEL-1 axis supports granulopoiesis and survival from sepsis in early life. Nat. Commun. 15:680.
Kolliniati O, Ieronymaki E, Vergadi E, Tsatsanis C. (2022) Metabolic Regulation of Macrophage Activation. J Innate Immun. 14:51-68.
Ieronymaki E, Theodorakis EM, Lyroni K, Vergadi E, Lagoudaki E, Al-Qahtani A, Aznaourova M, Neofotistou-Themeli E, Eliopoulos AG, Vaporidi K, Tsatsanis C. (2019) Insulin Resistance in Macrophages Alters Their Metabolism and Promotes an M2-Like Phenotype. J Immunol. 202:1786-1797.
Arranz A, Doxaki C, Vergadi E, Martinez de la Torre Y, Vaporidi K, Lagoudaki ED, Ieronymaki E, Androulidaki A, Venihaki M, Margioris AN, Stathopoulos EN, Tsichlis PN, Tsatsanis C. (2012) Akt1 and Akt2 protein kinases differentially contribute to macrophage polarization. Proc Natl Acad Sci U S A. 109:9517-22.
Androulidaki A, Iliopoulos D, Arranz A, Doxaki C, Schworer S, Zacharioudaki V, Margioris AN, Tsichlis PN, Tsatsanis C. (2009) The kinase Akt1 controls macrophage response to lipopolysaccharide by regulating microRNAs. Immunity 31:220-31.
Please find a complete list of publications here: https://pubmed.ncbi.nlm.nih.gov/?term=tsatsanis+c&sort=date