From the processing of environmental sensory cues to more elaborate cognitive functions, such as decision making, the mammalian brain has evolved to efficiently resolve the task at hand. Alongside, the basic building blocks of the neocortex, the pyramidal neurons, have adapted to perform diverse computational tasks, greatly enriching the achieved functions at the systems level. We investigate the properties of these computations, how they are regulated at the microcircuit level and how they are linked to specific behaviours, such as flexible decision making. We are also interested in how this machinery is dysregulated in pathological conditions. To achieve these goals, we combine experimental and theoretical approaches in order to perform physiological studies of pyramidal neurons in vivo and in silico.
Poirazi P, Papoutsi A. (2020) Illuminating dendritic function with computational models. Nat Rev Neurosci. 21:303-321.
Gidon A, Zolnik TA, Fidzinski P, Bolduan F, Papoutsi A, Poirazi P, Holtkamp M, Vida I, Larkum ME. (2020) Dendritic action potentials and computation in human layer 2/3 cortical neurons. Science. 367:83-87.
Park J, Papoutsi A, Ash RT, Marin MA, Poirazi P, Smirnakis SM. (2019) Contribution of apical and basal dendrites to orientation encoding in mouse V1 L2/3 pyramidal neurons. Nat Commun. 10:5372.
Papoutsi A, Kastellakis G, Poirazi P. (2017) Basal tree complexity shapes functional pathways in the prefrontal cortex. J Neurophysiol. 118:1970-1983.
Papoutsi A, Sidiropoulou K, Poirazi P. (2014) Dendritic nonlinearities reduce network size requirements and mediate ON and OFF states of persistent activity in a PFC microcircuit model. PLoS Comput Biol. 10:e1003764.
Illuminating dendritic function with computational models Poirazi P., Papoutsi A., Nature Reviews Neuroscience, May 2020.
Novel dendritic action potentials shape the computational properties of human layer 2/3 cortical neurons Gidon A., Zolnik T.A., Fidzinski P., Bolduan F., Papoutsi A., Poirazi P., Holtkamp M., Vida I., Larkum M.E. Science, January 2020.
Structured connectivity exploits NMDA non-linearitites to induce dimensionally diverse responses in a PFC circuit Stamatiadis S.S., Papoutsi A., Poirazi P. bioRxiv, August 2019.
Contribution of Apical and Basal Dendrites of L2/3 Pyramidal Neurons to Orientation Encoding in Mouse V1 Park J.*, Papoutsi A.*, Ash R.T., Marin M.A., Poirazi P.**, Smirnakis S.M.**. Nature Communications, November 2019. *equal first, ** equal last
Optically Induced Calcium-Dependent Gene Activation and Labeling of Active Neurons Using CaMPARI and Cal-Light Christian Ebner C., Ledderose J., Zolnik T.A., Dominiak S.E., Turko P., Papoutsi A., Poirazi P., Britta J.E., Vida I., Larkum M.E., Sachdev R.N.S. Frontiers in Synaptic Neuroscience, May 2019.
Basal tree complexity shapes functional pathways in the prefrontal cortex Papoutsi A., Kastellakis G., Poirazi P. Journal of Neurophysiology, October 2017.
Introduction to the Computational Neuroscience Special Section Remy S., Poirazi P., Papoutsi A. European Journal of Neuroscience, March 2017.
A Simulation Study on the Effects of Dendritic Morphology on Layer V PFC Pyramidal Cell Firing Behavior Psarrou M., Stefanou S. S., Papoutsi A., Tzivilaki A., Cutsuridis V., Poirazi P. Frontiers in Cellular Neuroscience, September 2014.
Dendritic nonlinearities reduce size requirements and mediate ON and OFF states of persistent activity in a PFC microcircuit model Papoutsi A., Sidiropoulou K., Poirazi P. Plos Comp. Biology, July 2014.
Modulatory effects of inhibition on persistent activity in a cortical microcircuit model Konstantoudaki X., Papoutsi A., Chalkiadaki K., Poirazi P., Sidiropoulou K. Frontiers in Neural Circuits, January 2014.
Induction and modulation of persistent activity in a layer V PFC microcircuit model Papoutsi A., Sidiropoulou K., Cutsuridis V., Poirazi P. Frontiers in Neural Circuits, October 2013.
Coding and Decoding with Dendrites Papoutsi A., Kastellakis G., Psarrou M., Anastasakis S., Poirazi P. Journal of Physiology-Paris, February 2013.
Memory Beyond Synaptic Plasticity: The Role of Intrinsic Neuronal Excitability Papoutsi A., Sidiropoulou K., Poirazi P., Book Chapter in Memory Mechanisms in Health and Disease: Mechanistic Basis of Memory, World Scientific Pub Co Inc., 2012.