Ioannis Mitroulis (Technical Univ. Dresden)
The focus of our research group is the regulation of myelopoiesis by the immune system. We focus on the changes that take place in the bone marrow during aging, regarding immune cell population that, in turn, drive the aging-related changes in hematopoiesis. Additionally, we study the role of immune cell populations, such as T cells and monocytes, in the progression of myeloid neoplasia, including myelodysplastic syndrome and acute myeloid leukemia. Our aim is to identify and characterize effector cell populations that can suppress leukemic stem cell clones, in an effort to identify possible targets for immunotherapies.
Lamprianidou E, Kordella C, …, Mitroulis I, Kotsianidis I. (2021) Modulation of IL-6/STAT3 signaling axis in CD4+FOXP3- T cells represents a potential antitumor mechanism of azacytidine. Blood Adv. 5:129-142.
Kalafati L, Kourtzelis I, …, Mitroulis I, Chavakis T. (2020) Innate Immune Training of Granulopoiesis Promotes Anti-tumor Activity. Cell. 183:771-785.
Kourtzelis I, Li X, Mitroulis I, Hajishengallis G, Chavakis T. (2019) DEL-1 promotes macrophage efferocytosis and clearance of inflammation. Nat Immunol. 20:40-49.
Mitroulis I, Ruppova K, et al. (2018) Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity. Cell. 172:147-161.
Mitroulis I, Chen LS, et al. (2017) Secreted protein Del-1 regulates myelopoiesis in the hematopoietic stem cell niche. J Clin Invest. 127:3624-3639.