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    From the processing of environmental sensory cues to more elaborate cognitive functions, such as decision making, the mammalian brain has evolved to efficiently resolve the task at hand. Alongside, the basic building blocks of the neocortex, the pyramidal neurons, have adapted to perform diverse computational tasks, greatly enriching the achieved functions at the systems level. We investigate the properties of these computations, how they are regulated at the microcircuit level and how they are linked to specific behaviours, such as flexible decision making. We are also interested in how this machinery is dysregulated in pathological conditions. To achieve these goals, we combine experimental approaches, including in vivo 2photon imaging, with theoretical modelling in order to perform physiological studies of pyramidal neurons in vivo and in silico.