Theologos M. Michaelidis is Associate Professor at the Department of Biological Applications and Technologies, at the University of Ioannina and an Associated Member of the BRI. He studied Biology at the University of Athens (Greece) and obtained his PhD in Molecular Biology from the Department of Biology at the University of Crete (1992). He has made postdoctoral research at the Department of Neurobiochemistry, Max Planck Institute for Psychiatry in Munich, and at the Department of Molecular Biology of the Cell, German Cancer Research Center in Heidelberg. He was employed as a University Assistant at the Department of Neuroscience, Innsbruck Medical University, Austria (2003-2006). He has used genetically modified animals to study the mechanisms of programmed cell death in the developing nervous system. His current research is focused on the analysis of the molecular pathways determining neuronal cell death and neurogenesis in the mammalian brain, using differential screening approaches as well as stem cell and transgenic animal models.
Michaelidis, T. M., G. Tzimagiorgis, N. Moschonas, and J. Papamatheakis. (1993). The human glutamate dehydrogenase gene family: gene organization and structural characterization. Genomics 16, 150-160.
Tsiotra, C. P., D. Karagogeos, K. Theodorakis, T. M. Michaelidis, W. S. Modi, J. A. Furley, T. M. Jessell, and J. Papamatheakis. (1993). Isolation of the cDNA and chromosomal localization of the gene (TAX1) encoding the human axonal glycoprotein TAG-1. Genomics 18, 562-567.
Shashidharan, P., T. M. Michaelidis, N. K. Robakis, A. Kretsovali, J. Papamatheakis, and A. Plaitakis. (1994). Novel human glutamate dehydrogenase expressed in neural and testicular tissues and encoded by an X-linked intronless gene. J. Biol. Chem. 269, 16971-16976.
Tzimagiorgis, G., T. M. Michaelidis, D. Lindholm, and H. Thoenen. (1996). Introduction of the negative selection marker into replacement vectors by a single ligation step. Nucleic Acids Res. 24, 3476-3477.
Ohga, Y., U. Zirrgiebel, S. Hamnér, T. M. Michaelidis, J. Cooper, H. Thoenen, and D. Lindholm. (1996). Cell density increases Bcl-2 and Bcl-x expression in addition to survival of cultured cerebellar granule neurons. Neuroscience 73, 913-917.
Michaelidis, T. M., M. Sendtner, J. D. Cooper, M. Airaksinen, B. Holtmann, M. Meyer, and H. Thoenen. (1996). Inactivation of the bcl-2 gene results in progressive degeneration of motoneurons, sensory and sympathetic neurons during early postnatal development. Neuron 17, 75-89.
Frade, J. M. and T. M. Michaelidis. (1997). Origin of eukaryotic programmed cell death: A consequence of aerobic metabolism? Bioessays 19, 827-832.
Boot-Handford, R. P., T. M. Michaelidis, M. C. Hillarby, A. Zambelli, J. Denton, J. A. Hoyland, A. J. Freemont, M. E. Grant, and G. A. Wallis. (1998). The bcl-2 knockout mouse exhibits marked changes in osteoblast phenotype and collagen deposition in bone as well as a mild growth plate phenotype. Int. J. Exp. Pathology 79, 329-335.
Heix, J., A., Vente, R. Voit, A. Budde, T. M. Michaelidis, and I. Grummt. (1998). Mitotic silencing of rRNA synthesis: Inactivation of the promoter selectivity factor SL1 by cdc2/cyclin B-mediated phosphorylation. EMBO J. 17, 7373-7381.
Cellerino, A., T. M. Michaelidis, J. J. Barski, M. Baehr, H. Thoenen, and M. Meyer. (1999). Retinal ganglion cell loss after the period of naturally occurring cell death in bcl-2-/- mice. Neuroreport 10, 1091-1095.
Hata R., F. Gillardon, T. M. Michaelidis, and K.-A. Hossmann. (1999). Targeted disruption of the bcl-2 gene in mice exacerbates focal ischemic brain injury. Metabolic Brain Disease 14, 117-124.
Gillardon, F., I. Moll, M. Meyer, and T. M. Michaelidis. (1999). Alterations in cell death and cell cycle progression in the UV-irradiated epidermis of bcl-2-deficient mice. Cell Death Differ. 6, 55-60.
Almeida, O. F. X., G. L. Condé, C. Crochemore, B. A. Demeneix, D. Fischer, A. H. S. Hassan, M. Meyer, F. Holsboer, and T. M. Michaelidis. (2000). Subtle shifts in the ratio between pro- and anti-apoptotic molecules following activation of corticosteroid receptors decide neuronal fate. FASEB J. 14, 779-790.
Post A., M. Rücker, F. Ohl, M. Uhr, F. Holsboer, O. F. X. Almeida, and T. M. Michaelidis. (2002). Mechanisms underlying the protective potential of -tocopherol (vitamin E) against haloperidol-associated neurotoxicity. Neuropsychopharmacology 26, 397-407.
Crochemore, C. T. M. Michaelidis, D. Fischer, J.-Ph. Loeffler, and O. F. X. Almeida. (2002). Enhancement of p53 activity and inhibition of neural cell proliferation by activated glucocorticoid receptors. FASEB J. 16, 761-770.
Michaelidis, T. M., and I. Grummt. (2002). Mechanism of inhibition of RNA polymerase I transcription by DNA-dependent protein kinase. Biol. Chem. 383, 1683-1690.
Tirard, M., J. Jasbinsek, O. F. X., Almeida and T. M. Michaelidis (2004). The manifold actions of PIAS proteins on the transcriptional activity of mineralocorticoid and glucocorticoid receptors in neural cells. J. Mol. Endocrinology, 32, 825-841.
Tirard, M., Almeida, O. F., Hutzler, P., Melchior, F. and T. M. Michaelidis (2007). Sumoylation and proteasomal activity determine the transactivation properties of the mineralocorticoid receptor. Mol. Cell. Endocrinol. 268, 20-29.
Apostolova, G., Dorn, R., Ka, S., Hallbook, F., Lundeberg, J., Liser, K., Hakim, V., Brodski, C., Michaelidis, T. M., and Dechant, G. (2007). Neurotransmitter phenotype-specific expression changes in developing sympathetic neurons. Mol. Cell. Neurosci. 35, 397-408.
Sotiropoulos, I., Catania, C., Riedemann, T., Fry, J. P., Breen, K. C., Michaelidis, T. M., and Almeida O. F. X. (2008) Glucocorticoids trigger Alzheimer disease-like pathobiochemistry in rat neuronal cells expressing human tau. J Neurochem. 107, 385-397.
Michaelidis, T. M. and Lie, D. C. (2008) Wnt signaling and neural stem cells: caught in the Wnt web. Cell Tissue Res. 331, 193-210.
Mu, LF., Berti L., Masserdotti, G., Covic, M., Michaelidis, T.M., Doberauer, K., Merz, K., Rehfeld, F., Haslinger, A., Wegner, M., Sock, E., Lefebvre, V., Couillard-Despres, S., Aigner, L., Berninger, B., Lie, C.D. (2012) “SoxC transcription factors are required for neuronal differentiation in adult hippocampal neurogenesis.” JOURNAL OF NEUROSCIENCE, 32(9): 3067-3080.