Christos Andronis
Bioinformatics Lead
Christos Andronis currently leads the Bioinformatics Unit at IMBB-FORTH. Before joining IMBB, Christos has held similar positions at Deus ex Machina (ekmechanes.com), Biovista and Protein Pathways, Inc. Apart from coordinating projects that involve Bioinformatics omics data analyses, Christos has been leading biomedical data integration and harmonization projects using Ontological frameworks and controlled vocabularies following FAIR principles. In his past positions, Dr. Andronis has also been heavily involved in the systematic drug repurposing and drug adverse event predictions fields. Dr. Andronis has a long-standing interest in transforming experimental and textual data into knowledge useful to biomedical research.
Selected Publications
Nymark P, Clerbaux LA, Amorim MJ, Andronis C, de Bernardi F, Bezemer GFG, Coecke S, Gavins FNE, Jacobson D, Lekka E, Margiotta-Casaluci L, Martens M, Mayasich SA, Mortensen HM, Kim YJ, Sachana M, Tanabe S, Virvilis V, Edwards SW, Halappanavar S. Building an Adverse Outcome Pathway network for COVID-19. Front Syst Biol. 2024 Jun 6;4:1384481. doi: 10.3389/fsysb.2024.1384481. PMID: 40206642; PMCID: PMC11977783.
Bardani E, Katsarou K, Mitta E, Andronis C, Štefková M, Wassenegger M, Kalantidis K. Broadening the Nicotiana benthamiana research toolbox through the generation of dicer-like mutants using CRISPR/Cas9 approaches. Plant Sci. 2025 Jul;356:112490. doi: 10.1016/j.plantsci.2025.112490. Epub 2025 Mar 31. PMID: 40174865.
Chen Y, Shi Y, Wang Z, An X, Wei S, Andronis C, Vontas J, Wang JJ, Niu J. dsRNAEngineer: a web-based tool of comprehensive dsRNA design for pest control. Trends Biotechnol. 2025 Apr;43(4):969-983. doi: 10.1016/j.tibtech.2025.01.002. Epub 2025 Feb 8. PMID: 39924355.
Kallemi P, Verret F, Andronis C, Ioannidis N, Glampedakis N, Kotzabasis K, Kalantidis K. Stress-related transcriptomic changes associated with GFP transgene expression and active transgene silencing in plants. Sci Rep. 2024 Jun 10;14(1):13314. doi: 10.1038/s41598-024-63527-5. PMID: 38858413; PMCID: PMC11164987.
Tselika M, Belmezos N, Kallemi P, Andronis C, Chiumenti M, Navarro B, Lavigne M, Di Serio F, Kalantidis K, Katsarou K. PSTVd infection in Nicotiana benthamiana plants has a minor yet detectable effect on CG methylation. Front Plant Sci. 2023 Oct 31;14:1258023. doi: 10.3389/fpls.2023.1258023. PMID: 38023875; PMCID: PMC10645062.
Bampali K, Koniuszewski F, Vogel FD, Fabjan J, Andronis C, Lekka E, Virvillis V, Seidel T, Delaunois A, Royer L, Rolf MG, Giuliano C, Traebert M, Roussignol G, Fric-Bordat M, Mazelin-Winum L, Bryant SD, Langer T, Ernst M. GABAA receptor-mediated seizure liabilities: a mixed-methods screening approach. Cell Biol Toxicol. 2023 Dec;39(6):2793-2819. doi: 10.1007/s10565-023-09803-y. Epub 2023 Apr 24. PMID: 37093397; PMCID: PMC10693519.
Andronis C, Sharma A, Virvilis V, Deftereos S, Persidis A. Literature mining, ontologies and information visualization for drug repurposing. Brief Bioinform. 2011 Jul;12(4):357-68. doi: 10.1093/bib/bbr005. Epub 2011 Jun 28. PMID: 21712342.
Deftereos SN, Andronis C, Friedla EJ, Persidis A, Persidis A. Drug repurposing and adverse event prediction using high-throughput literature analysis. Wiley Interdiscip Rev Syst Biol Med. 2011 May-Jun;3(3):323-34. doi: 10.1002/wsbm.147. Epub 2011 Feb 16. PMID: 21416632.
Lu SX, Knowles SM, Andronis C, Ong MS, Tobin EM. CIRCADIAN CLOCK ASSOCIATED1 and LATE ELONGATED HYPOCOTYL function synergistically in the circadian clock of Arabidopsis. Plant Physiol. 2009 Jun;150(2):834-43. doi: 10.1104/pp.108.133272. Epub 2009 Feb 13. PMID: 19218364; PMCID: PMC2689956.
Andronis C, Barak S, Knowles SM, Sugano S, Tobin EM. The clock protein CCA1 and the bZIP transcription factor HY5 physically interact to regulate gene expression in Arabidopsis. Mol Plant. 2008 Jan;1(1):58-67. doi: 10.1093/mp/ssm005. Epub 2007 Oct 11. PMID: 20031914.
Mastellos D, Andronis C, Persidis A, Lambris JD. Novel biological networks modulated by complement. Clin Immunol. 2005 Jun;115(3):225-35. doi: 10.1016/j.clim.2005.03.012. PMID: 15893689.