Maria Markaki (Staff Scientist - Tavernarakis Lab)
My main research activities focus on the investigation of the molecular mechanisms underlying ageing and the identification of molecular pathways that connect ageing and neurodegeneration. Emphasis is given to examining the effects of ageing on physiological autophagic mechanisms, as well as, the link between autophagy and molecular pathways implicated in ageing and age-associated susceptibility to disease. For this purpose, the nematode Caenorhabditis elegans is used as a model organism.
Markaki M, Tavernarakis N. (2020) Caenorhabditis elegans as a model system for human diseases. Curr Opin Biotechnol. 63:118-125.
Rieckher M, Markaki M, Princz A, Schumacher B, Tavernarakis N. (2018) Maintenance of Proteostasis by P Body-Mediated Regulation of eIF4E Availability during Aging in Caenorhabditis elegans. Cell Rep. 25:199-211.
Pietrocola F, Castoldi F, Markaki M, Lachkar S, Chen G, Enot DP, Durand S, Bossut N, Tong M, Malik SA, Loos F, Dupont N, Mariño G, Abdelkader N, Madeo F, Maiuri MC, Kroemer R, Codogno P, Sadoshima J, Tavernarakis N, Kroemer G. (2018) Aspirin Recapitulates Feature of Caloric Restriction. Cell Rep. 22:2395-2407.
Niso-Santano M, Malik SA, Pietrocola F, Bravo-San Pedro JM, Mariño G, Cianfanelli V, Ben-Younès A, Troncoso R, Markaki M, Sica V, Izzo V, Chaba K, Bauvy C, Dupont N, Kepp O, Rockenfeller P, Wolinski H, Madeo F, Lavandero S, Codogno P, Harper F, Pierron G, Tavernarakis N, Cecconi F, Maiuri MC, Galluzzi L, Kroemer G. (2015) Unsaturated fatty acids induce non-canonical autophagy. EMBO J. 34:1025-1041.
Morselli E, Maiuri MC, Markaki M, Megalou E, Pasparaki A, Palikaras K, Criollo A, Galluzzi L, Malik SA, Vitale I, Michaud M, Madeo F, Tavernarakis N, Kroemer G. (2010) The lifespan–prolonging effect of sirtuin-1 is mediated by autophagy. Autophagy. 6:186-188.
Markaki M. and Tavernarakis N. (2020) Editorial: Autophagy mechanisms and roles: recent advances and implications. FEBS Journal, 287: 5024-5026.
Markaki M. and Tavernarakis N. (2020) Editorial: Mitophagy in physiology and pathology. Mechanisms of Ageing and Development, 190: 111291.
Markaki M. and Tavernarakis N. (2020) Mitochondrial turnover and homeostasis in ageing and neurodegeneration. FEBS Letters, 594: 2370-2379.
Markaki M. and Tavernarakis N. (2020) Caenorhabditis elegans as a model system for human diseases. Current Opinion in Biotechnology, 63, 118-125.
Chen G., Xie W., Nah J., Sauvat A., Liu P., Pietrocola F., Sica V., Carmona-Gutierrez D., Zimmermann A., Pendl T., Tadic J., Bergmann M., Hofer S. J., Markaki M., Tavernarakis N., Domuz L. Lachkar S., Sadoshima J., Madeo F., Kepp O. and Kroemer G. (2019) 3,4-Dimethoxychalcone induces autophagy through activation of the transcription factors TFE3 and TFEB. EMBO Molecular Medicine, 11: e10469.
Kounakis K., Chaniotakis M., Markaki M. and Tavernarakis N. (2019) Emerging roles of lipophagy in ageing and age-related diseases. Frontiers in Cell and Developmental Biology, 7: 185.
Rieckher M., Markaki M., Princz A. and Tavernarakis N. (2018) Maintenance of proteostasis by P body-mediated regulation of eIF4E availability during ageing in Caenorhabditis elegans. Cell Reports, 25: 199-211.
Markaki M., Palikaras K. and Tavernarakis N. (2018) Novel insights into the anti-ageing role of mitophagy. International Review of Cell and Molecular Biology, 340: 169-208 (equal contributionby Markaki M and Palikaras K).
Pietrocola F. *, Castoldi F. *, Markaki M. *, Lachkar S., Chen G., Enot D. P., Durand S., Bossut N., Tong M., Malik S. A., Loos F., Dupont N., Marino G., Abdelkader N., Madeo F., Maiuri M. C., Kroemer R., Codogno P., SadoshimaJ., Tavernarakis N. and Kroemer G. (2018) Aspirin recapitulates features of caloric restriction. Cell Reports, 22: 2395-2407 (*equal contribution).
Palikaras K., Daskalaki I., Markaki M. and Tavernarakis N. (2017) Mitophagy and age-related pathologies: Development of new therapeutics by targeting mitochondrial turnover. Pharmacology and Therapeutics, 178: 154-174.
Lionaki E. *, Markaki M. *, Palikaras K*. and Tavernarakis N. (2015) Mitochondria, autophagy and age-associated neurodegenerative diseases: New insights into a complex interplay. Biochimica et Biophysica Acta-Bioenergetics, 1847: 1412-1423 (*equal contribution).
Niso-Santano M., Malik S. A., Pietrocola F., Bravo-San Pedro J. M., Mariño G., Cianfanelli V., Ben-Younès A., Troncoso R., Markaki M., Sica V., Izzo V., Chaba K., Bauvy C., Dupont N., Kepp O., Rockenfeller P., Wolinski H., Madeo F., Lavandero S., Codogno P., Harper F., Pierron G., Tavernarakis N., Cecconi F., Maiuri M. C., Galluzzi L. and Kroemer G. (2015) Unsaturated fatty acids induce non-canonical autophagy. EMBO Journal, 34: 1025-1041.
Kyriakakis E.*, Markaki M.* and Tavernarakis N. (2015) Caenorhabditis elegans as a model for cancer research. Molecular and Cellular Oncology, 2: e975027 (*equal contribution).
Büttner S., Broeskamp F., Sommer C., Markaki M., Habernig L., Alavian-Ghavanini A., Carmona-Gutierrez D., Eisenberg T., Michael E., Kroemer G., Tavernarakis N., Sigrist S. J. and Madeo F. (2014) Spermidine protects against α-synuclein neurotoxicity. Cell Cycle, 13: 3903-3908.
Kypri E., Cristodoulou A., Maimaris Y., Lethan M., Markaki M., Lyssandrou C., Lederer C. W., Tavernarakis N., Geimer S., Pedersen L. B. and Santama N. (2014) The nucleotide binding proteins Nubp1 and Nubp2 are negative regulators of ciliogenesis. Cellular and Molecular Life Sciences, 71: 517-538.
Nikoletopoulou V., Markaki M., Palikaras K. and Tavernarakis N. (2013) Crosstalk between apoptosis, necrosis and autophagy. Biochimica et Biophysica Acta-Molecular Cell Research, 1833: 3448-3459.
Buttner S., Habernig L., Broeskamp F., Ruli D, Vogtle F. N., Vlachos M., Macchi F., Kuttner V., Carmona-Gutierrez D., Eisenberg T., Ring J., Markaki M., Taskin A. A., Benke S., Ruckenstuhl C., Braun R., Van den Haute C., Bammens T., van der Perren A., Frohlich K.-U., Winderickx J., Kroemer G., Baekelandt V., Tavernarakis N., Kovacs G. G., Dengjel J., Mesinger C., Sigrist S. J. and Madeo F. (2013) Endonuclease G mediates a-synuclein cytotoxicity during Parkinson's disease. EMBO Journal, 32: 3041-3054.
Kalajdzic P., Markaki M., Oehler S. and Savakis C. (2013) Imidacloprid does not induce Cyp genes involved in insecticide resistance of a mutant Drosophila melanogaster line. Food and Chemical Toxicology 60, 355–359.
Kalajdzic P., Oehler S., Markaki M. and Savakis C. (2013) Toxicology and cytogenetic analysis of a Drosophila melanogaster mutant resistant to imidacloprid and DDT. Genetica, 45, No. 3, 929-938.
Markaki M. and Tavernarakis N. (2013) Metabolic control by TOR and autophagy during ageing. Gerontology, 59, 340-348.
Lionaki E*., Markaki M.* and Tavernarakis N. (2012) Autophagy and ageing: Insights from invertebrate model organisms. Ageing Research Reviews, 12: 413-428 (*equal contribution).
Klionsky D. J., ... Markaki M., ... Tavernarakis N., et al. (2012) Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy, 8: 445-544.
Markaki M. and Tavernarakis N. (2011) The role of autophagy in genetic pathways influencing ageing. Biogerontology, 12: 377-386.
Markaki M. and Tavernarakis N. (2010) Modelling human diseases in Caenorhabditis elegans. Biotechnology Journal, 5: 1261-1276.
Morcelli E., Maiuri M.C., Markaki M., Megalou E., Pasparaki A., Palikaras K., Galuzzi L., Criolo A., Malik S.A., Madeo F., Tavernarakis N. and Kroemer G. (2010) The lifespan –prolonging effect of sirtuin-1 is mediated by autophagy. Autophagy, 6:186-188.
Morcelli E., Maiuri M.C., Markaki M., Megalou E., Pasparaki A., Palikaras K., Galuzzi L., Criolo A., Malik S.A., Madeo F., Tavernarakis N. and Kroemer G. (2009) Caloric restriction and resveratrol prolong longevity via the sirtuin-1 mediated induction of autophagy. Cell death and disease, 1:1-10.
Markaki M., Drabek D., Livadaras I., Craig R.K., Grosveld F. and Savakis C. (2007) Stable expression of human growth hormone over 50 generations in transgenic insect larvae. Transgenic Res., 16:99-107.
Markaki M., Craig R.K. and Savakis C. (2004) Insect Population Control Using Female Specific Pro-drug Activation. Insect Biochem. Mol. Biol., 34: 131-137.