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Iannis Talianidis

Iannis Talianidis

Research Director
Email address
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Phone
+30-2810-391162
Fax
+30-2810-391101

Dr Iannis Talianidis received his diploma from the Semmelweis University Medical School in Budapest Hungary in 1981. He continued his post-graduate studies in the Department of Biochemistry of the same University, where he obtained his PhD degree in Biology. Between 1985 and 1987, Dr Talianidis worked as a postdoctoral researcher at the Dept. of Biological Chemistry of Harvard University Medical School in Boston. He then continued his postdoctoral studies at the Dept. of Chemistry of University of California Berkeley until 1990, when he was elected Group Leader in IMBB-FORTH in Greece. In 2007 he was appointed as Director of the Institute of Molecular Biology and Genetics at the BSRC Al. Fleming in Vari. At the end of 2016 he moved back to the IMBB-FORTH. Dr Talianidis is an elected member of EMBO (2004), Academia Europaea (2013) and the Hungarian Academy of Sciences (2013). From early 2017 he is a holder of the AXA-Chair in Epigenetics position. His research as principal investigator has been funded by 8 national programs and 24 international, mostly EU programs. He is a recipient of an ERC Advanced Investigator Award (2012) and has coordinated 9 EU collaborative programs.

His main research interest is on the field of hepatic gene expression mechanisms with focus on chromatin organization and the regulated assembly of the transcription machinery on genes involved in the regulation of liver development, hepatic metabolic pathways and hepatocarcinogenesis.

Nikolaou KC., Moulos P., Harokopos V., Chalepakis G., Talianidis I. (2017) Kmt5a Controls Hepatic Metabolic Pathways by Facilitating RNA Pol II Release from Promoter-Proximal Regions. Cell Rep. 20: 909-922.

Elkouris M, Kontaki H, Stavropoulos A, Anastasia Antonoglou A, Nikolaou KC, Samiotaki M, Szantai E, Brown PJ, Sideras P, Panayotou G, Talianidis I. (2016) SET9-mediated regulation of TGF-b signaling links protein methylation to pulmonary fibrosis. Cell Rep. 15:2733-2744.

Sarris ME, Moulos P, Haroniti A, Giakountis A, Talianidis I. (2016) Smyd3 is a transcriptional potentiator of multiple cancer-promoting genes and required for liver and colon cancer development. Cancer Cell 29:354-366.

Nikolaou KC, Moulos P, Chalepakis G, Hatzis P, Oda H, Reinberg D, Talianidis I. (2015) Spontaneous development of hepatocellular carcinoma with cancer stem cell properties in PR-SET7-deficient livers. EMBO J. 34:430-447.

Nikolaou K, Tsagaratou A, Eftychi C, Kollias G, Mosialos G, Talianidis I. (2012) Inactivation of the deubiquitinase CYLD in hepatocytes causes apoptosis, inflammation, fibrosis and cancer. Cancer Cell 21:738-75

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Nikolaou KC., Moulos P., Harokopos V., Chalepakis G., Talianidis I. (2017) Kmt5a Controls Hepatic Metabolic Pathways by Facilitating RNA Pol II Release from Promoter-Proximal Regions. Cell Rep. 20: 909-922.

Giakountis A., Moulos P., Sarris ME., Hatzis P., Talianidis I. (2017) Smyd3-associated regulatory pathways in cancer. Semin Cancer Biol. 42:654-663.

Elkouris M., Kontaki H., Stavropoulos A., Anastasia Antonoglou A., Nikolaou KC., Samiotaki M., Szantai E., Brown PJ., Sideras P., Panayotou G., Talianidis I. (2016) SET9-mediated regulation of TGF-b signaling links protein methylation to pulmonary fibrosis. Cell Rep. 15:2733-2744.

Sarris ME, Moulos P, Haroniti A, Giakountis A., Talianidis I. (2016) Smyd3 is a transcriptional potentiator of multiple cancer-promoting genes and required for liver and colon cancer development. Cancer Cell 29:354-366.

Lugli N, Kamileri I, Keogh A, Malinka T, Sarris M, Talianidis I, Schaad O, Candinas D, Stroka D, and Halazonetis TD. (2016) R-spondin 1 and noggin facilitate expansion of resident stem cells from non-damaged gallbladders. EMBO Rep. 17:769-779.

Nikolaou KC, Moulos P, Chalepakis G, Hatzis P, Oda H, Reinberg D, Talianidis I. (2015) Spontaneous development of hepatocellular carcinoma with cancer stem cell properties in PR-SET7-deficient livers. EMBO J. 34:430-447.

Schmitt BM, Rudolph KL, Karagianni P, Fonseca NA, White RJ, Talianidis I, Odom DT, Marioni JC, Kutter C. (2014) High-resolution mapping of transcriptional dynamics across tissue development reveals a stable mRNA-tRNA interface. Genome Res. 24:1797-1807.

Duteil D., Metzger E., Willmann D., Karagianni P., Friedrichs N., Greschik H., Günther T., Buettner R., Talianidis I., Metzger D., Schüle R. (2014) LSD1 promotes oxidative metabolism of white adipose tissue. Nature Comm. 5:4093

Sarris M, Nikolaou K, Talianidis I. (2014) Context-specific regulation of cancer epigenomes by histone and transcription factor methylation. Oncogene 33:1207-1217.

Nikolaou K, Sarris M, Talianidis I. (2013) Molecular pathways: the complex roles of inflammation pathways in the development and treatment of liver cancer. Clin Cancer Res. 19:2810-2816.

Stefflova K., Thyber D., Wilson MD., Streeter I., Aleksic J., Karagianni P., Brazma A., Adams DJ., Talianidis I., Marioni JC., Flicek P., Odom DT. (2013) Cooperativity and Rapid Evolution of Cobound Transcription Factors in Closely Related Mammals. Cell 154:530-540.

Nikolaou K., Tsagaratou A., Eftychi C., Kollias G., Mosialos G., Talianidis I. (2012) Inactivation of the deubiquitinase CYLD in hepatocytes causes apoptosis, inflammation, fibrosis and cancer. Cancer Cell 21:738-75

Kontaki H., Talianidis I. (2010) Lysine methylation regulates E2F1-induced cell death. Mol Cell 39:152-160.

Schmidt D, Wilson MD, Ballester B, Schwalie PC, Brown GD, Marshall A, Kutter C, Watt S, Martinez-Jimenez CP, Mackay S, Talianidis I, Flicek P, Odom DT. (2010) Five-Vertebrate ChIP-seq Reveals the Evolutionary Dynamics of Transcription Factor Binding. Science 328:1036-1040.

Martinez-Jimenez CP, Kyrmizi I, Cardot P, Gonzalez FJ, Talianidis I. (2010) Hepatocyte nuclear factor 4alpha coordinates a transcription factor network regulating hepatic fatty acid metabolism. Mol Cell Biol. 30:565-577.

Tatarakis A, Margaritis T, Martinez-Jimenez CP, Kouskouti A, Mohan WS 2nd, Haroniti A, Kafetzopoulos D, Tora L, Talianidis I. (2008) Dominant and redundant functions of TFIID involved in the regulation of hepatic genes. Mol Cell 31:531-543.