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Iannis Talianidis

Iannis Talianidis

Research Director, AXA Chair in Epigenetics
Email address
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Phone
+30-2810-391162
Fax
+30-2810-391101

We study epigenetic mechanisms regulating liver development, hepatocarcinogenesis and metabolism. Our research aims at understanding the interplay between chromatin modifying enzymes and transcription factors in regulating gene expression.

The main research interest of our group is to study the molecular mechanisms governing the transcriptional regulation of liver-specific genes. Our research is broadly centered around the analysis of the function of hepatic regulators and the general transcription machinery. We use biochemical, genetic and cell biology approaches to study the chromatin organization and the regulated assembly of the transcription machinery on hepatic genes involved in the regulation of various metabolic pathways and/or hepatocyte differentiation. Focus is on studies of epigenetic mechanisms with an ultimate goal to describe the complete Epigenomes matching the hepatocyte cell type at different stages of liver development and during hepatocarcinogenesis.

Elkouris M, Kontaki H, Stavropoulos A, Anastasia Antonoglou A, Nikolaou KC, Samiotaki M, Szantai E, Brown PJ, Sideras P, Panayotou G, Talianidis I. (2016) SET9-mediated regulation of TGF-b signaling links protein methylation to pulmonary fibrosis. Cell Rep. 15:2733-2744.

Sarris ME, Moulos P, Haroniti A, Giakountis A, Talianidis I. (2016) Smyd3 is a transcriptional potentiator of multiple cancer-promoting genes and required for liver and colon cancer development. Cancer Cell 29:354-366.

Nikolaou KC, Moulos P, Chalepakis G, Hatzis P, Oda H, Reinberg D, Talianidis I. (2015) Spontaneous development of hepatocellular carcinoma with cancer stem cell properties in PR-SET7-deficient livers. EMBO J. 34:430-447.

Stefflova K, Thyber D, Wilson MD, Streeter I, Aleksic J, Karagianni P, Brazma A, Adams DJ, Talianidis I, Marioni JC, Flicek P, Odom DT. (2013) Cooperativity and Rapid Evolution of Cobound Transcription Factors in Closely Related Mammals. Cell 154:530-540.

Nikolaou K, Tsagaratou A, Eftychi C, Kollias G, Mosialos G, Talianidis I. (2012) Inactivation of the deubiquitinase CYLD in hepatocytes causes apoptosis, inflammation, fibrosis and cancer. Cancer Cell 21:738-75

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Giakountis A., Moulos P., Sarris ME., Hatzis P., Talianidis I. (2017) Smyd3-associated regulatory pathways in cancer. Semin Cancer Biol. doi: 10.1016/j.semcancer.2016.08.008.

Elkouris M., Kontaki H., Stavropoulos A., Anastasia Antonoglou A., Nikolaou KC., Samiotaki M., Szantai E., Brown PJ., Sideras P., Panayotou G., Talianidis I. (2016) SET9-mediated regulation of TGF-b signaling links protein methylation to pulmonary fibrosis. Cell Rep. 15:2733-2744.

Sarris ME, Moulos P, Haroniti A, Giakountis A., Talianidis I. (2016) Smyd3 is a transcriptional potentiator of multiple cancer-promoting genes and required for liver and colon cancer development. Cancer Cell 29:354-366.

Lugli N, Kamileri I, Keogh A, Malinka T, Sarris M, Talianidis I, Schaad O, Candinas D, Stroka D, and Halazonetis TD. (2016) R-spondin 1 and noggin facilitate expansion of resident stem cells from non-damaged gallbladders. EMBO Rep. 17:769-779.

Nikolaou KC, Moulos P, Chalepakis G, Hatzis P, Oda H, Reinberg D, Talianidis I. (2015) Spontaneous development of hepatocellular carcinoma with cancer stem cell properties in PR-SET7-deficient livers. EMBO J. 34:430-447.

Schmitt BM, Rudolph KL, Karagianni P, Fonseca NA, White RJ, Talianidis I, Odom DT, Marioni JC, Kutter C. (2014) High-resolution mapping of transcriptional dynamics across tissue development reveals a stable mRNA-tRNA interface. Genome Res. 24:1797-1807.

Duteil D., Metzger E., Willmann D., Karagianni P., Friedrichs N., Greschik H., Günther T., Buettner R., Talianidis I., Metzger D., Schüle R. (2014) LSD1 promotes oxidative metabolism of white adipose tissue. Nature Comm. 5:4093

Sarris M, Nikolaou K, Talianidis I. (2014) Context-specific regulation of cancer epigenomes by histone and transcription factor methylation. Oncogene 33:1207-1217.

Nikolaou K, Sarris M, Talianidis I. (2013) Molecular pathways: the complex roles of inflammation pathways in the development and treatment of liver cancer. Clin Cancer Res. 19:2810-2816.

Stefflova K., Thyber D., Wilson MD., Streeter I., Aleksic J., Karagianni P., Brazma A., Adams DJ., Talianidis I., Marioni JC., Flicek P., Odom DT. (2013) Cooperativity and Rapid Evolution of Cobound Transcription Factors in Closely Related Mammals. Cell 154:530-540.

Nikolaou K., Tsagaratou A., Eftychi C., Kollias G., Mosialos G., Talianidis I. (2012) Inactivation of the deubiquitinase CYLD in hepatocytes causes apoptosis, inflammation, fibrosis and cancer. Cancer Cell 21:738-75

Kontaki H., Talianidis I. (2010) Lysine methylation regulates E2F1-induced cell death. Mol Cell 39:152-160.

Schmidt D, Wilson MD, Ballester B, Schwalie PC, Brown GD, Marshall A, Kutter C, Watt S, Martinez-Jimenez CP, Mackay S, Talianidis I, Flicek P, Odom DT. (2010) Five-Vertebrate ChIP-seq Reveals the Evolutionary Dynamics of Transcription Factor Binding. Science 328:1036-1040.

Martinez-Jimenez CP, Kyrmizi I, Cardot P, Gonzalez FJ, Talianidis I. (2010) Hepatocyte nuclear factor 4alpha coordinates a transcription factor network regulating hepatic fatty acid metabolism. Mol Cell Biol. 30:565-577.

Tatarakis A, Margaritis T, Martinez-Jimenez CP, Kouskouti A, Mohan WS 2nd, Haroniti A, Kafetzopoulos D, Tora L, Talianidis I. (2008) Dominant and redundant functions of TFIID involved in the regulation of hepatic genes. Mol Cell 31:531-543.